COVID-19 preclinical studies

Preclinical In Vitro Studies

The following is an updated list of studies with published in vitro experimental results. The studies were complied using several well known preprint and publication databases relating to SARS-CoV-2 and COVID-19. Drug names and numerical EC50/IC50 results were extracted using simple NLP scripts along with a correlation label. An indirect correlation means that although a drug name was extracted, it could not be mapped to the experimental value using our current algorithm. It should be noted that this list is to be used only as a reference for further investigation, and the drug names and extracted numerical values are neither 100% accurate nor complete.

Last Updated: October 18, 2022


Drug name DOI Assay Value Units Correlation Date Added
Acetamide 10.1080/10426507.2020.1828886 EC50 9.8 um direct 20221018
Acrylamide 10.1101/2020.09.21.299776 IC50 low micromolar ic50 direct 20221018
Adenosine 10.1101/2020.04.27.064279 EC50 0.01 direct 20221018
Adenosine 10.2139/ssrn.3588829 EC50 0.01 um direct 20221018
Amodiaquine 10.1101/2021.01.08.425825 IC50 5.8 um direct 20221018
Amprenavir 10.1101/2020.06.26.174698 IC50 1 direct 20221018
Andrographolide 10.21203/rs.3.rs-24311/v1 EC50 10 um direct 20221018
Arbidol 10.1016/j.ejps.2020.105631 EC50 5.48 um direct 20221018
Arbidol 10.1101/2020.04.29.20085761 EC50 5.48 um direct 20221018
Artemether 10.1101/2020.10.05.326637 EC50 7 direct 20221018
Artemether 10.1101/2021.01.08.425825 IC50 70 micro direct 20221018
Artemisinin 10.1101/2020.10.05.326637 EC50 7 direct 20221018
Artemisinin 10.1101/2022.07.22.501141 IC50 0.5 micro direct 20221018
Artemisinin 10.1101/2021.09.08.459260 IC50 0.3 direct 20221018
Artemisinin 10.1101/2021.01.08.425825 IC50 0.1 direct 20221018
Artesunate 10.1101/2020.10.05.326637 EC50 7 direct 20221018
Artesunate 10.1101/2021.01.08.425825 IC50 70 micro direct 20221018
Asenapine 10.1101/2020.06.05.135996 IC50 0.34 um direct 20221018
Astodrimer 10.1101/2020.08.20.260190 EC50 0.09 direct 20221018
Asunaprevir 10.1101/2020.12.02.408112 EC50 72 direct 20221018
Atazanavir 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Auranofin 10.1101/2020.05.28.120642 IC50 3 direct 20221018
Azelastine 10.1101/2020.09.15.296228 EC50 6 direct 20221018
Azithromycin 10.21203/rs.3.rs-36439/v1 EC50 0.008 um direct 20221018
Azithromycin 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Azithromycine 10.1101/2020.04.03.023846 EC50 20 micro direct 20221018
Baicalein 10.1101/2020.04.10.035824 IC50 0.39 um direct 20221018
Baloxavir 10.1016/j.ejps.2020.105631 EC50 5.48 um direct 20221018
Baloxavir 10.1101/2020.04.29.20085761 EC50 5.48 um direct 20221018
Bedaquiline 10.1101/2020.08.28.271957 IC50 40 direct 20221018
Boceprevir 10.1101/2020.12.02.408112 EC50 40 um direct 20221018
Boceprevir 10.1101/2020.04.20.051581 IC50 submicromolar ic50 values None direct 20221010
Boceprevir 10.1101/2020.07.10.197889 EC50 0.95 direct 20221018
Boceprevir 10.1101/2020.04.20.051581 EC50 0.49 um direct 20221018
Boceprevir 10.1101/2020.08.28.271957 IC50 40 direct 20221018
Bortezomib 10.1016/j.arcmed.2020.10.002 IC50 47 direct 20221018
Camostat 10.1101/2020.06.23.167544 IC50 0.27 nm direct 20221018
Camostat 10.21203/rs.3.rs-34021/v4 EC50 26000 direct 20221018
Camostat 10.21203/rs.3.rs-34021/v5 EC50 26000 direct 20221018
Carbon 10.1101/2021.12.18.473326 IC50 3 direct 20221018
Carmofur 10.1101/2020.04.09.033233 EC50 24.3 direct 20221018
Ceftazidime 10.1101/2020.09.14.295956 IC50 113.2 direct 20221018
Chloroquine 10.1101/2020.08.29.273441 IC50 3 direct 20221018
Chloroquine 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Chloroquine 10.30651/jqm.v4i2.4998 EC50 1 um direct 20221018
Chloroquine 10.1093/cid/ciaa237 EC50 0.72 um direct 20221018
Chloroquine 10.1101/2020.06.22.165712 EC50 1.32 direct 20221018
Chymotrypsin 10.1101/2020.12.16.422677 IC50 1 direct 20221018
Ciluprevir 10.1101/2020.07.10.197889 EC50 0.95 direct 20221018
Clomiphene 10.1101/2020.06.05.135996 IC50 0.34 um direct 20221018
Cobicistat 10.1101/2020.06.22.165712 EC50 0.77 direct 20221018
Danoprevir 10.1101/2020.03.22.20034041 IC50 0.29 nm direct 20221018
Danoprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Diclazuril 10.1101/2021.03.19.435806 IC50 29 direct 20221018
Dihydroartemisinin 10.1101/2021.01.08.425825 IC50 70 micro direct 20221018
Dipyridamole 10.1101/2020.02.27.20027557 EC50 100 nm direct 20221018
Disulfiram 10.1101/2021.09.17.460613 EC50 154 nm direct 20221018
Efonidipine 10.1101/2020.08.28.271957 IC50 40 direct 20221018
Enoxaparin 10.1101/2020.06.08.140236 IC50 599 direct 20221018
Faldaprevir 10.1101/2020.12.02.408112 EC50 72 direct 20221018
Favipiravir 10.1016/j.ejps.2020.105631 EC50 5.48 um direct 20221018
Favipiravir 10.1101/2020.04.29.20085761 EC50 5.48 um direct 20221018
Favipiravir 10.21203/rs.3.rs-24311/v1 EC50 10 um direct 20221018
Gabexate 10.1101/2020.06.23.167544 IC50 0.27 nm direct 20221018
Galidesivir 10.1101/2021.03.25.436935 IC50 1 direct 20221018
Glecaprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Gramicidin 10.1101/2021.10.21.465254 EC50 1.571 direct 20221018
Grazoprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Heparin 10.1101/2020.05.10.087288 IC50 38 nm direct 20221018
Heparin 10.1101/2020.05.21.107870 IC50 0.05 direct 20221018
Heparin 10.1101/2020.06.08.140236 IC50 599 direct 20221018
Heparin 10.1101/2020.04.14.041459 IC50 0.056 direct 20221018
Honokiol 10.1101/2022.07.26.501656 EC50 7.8 micro direct 20221018
Hopeaphenol 10.1101/2021.04.29.442010 IC50 0.11 um direct 20221018
Hydroxocobalamin 10.1101/2020.07.17.207019 IC50 0.26 um direct 20221018
Hydroxychloroquine 10.1093/cid/ciaa623 EC50 to the free plasma hydroxychloroquine concentration direct 20221018
Hydroxychloroquine 10.1101/2020.07.12.199059 EC50 2.6 direct 20221018
Hydroxychloroquine 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Hydroxychloroquine 10.1093/cid/ciaa237 EC50 0.72 um direct 20221018
Hydroxychloroquine 10.1101/2020.11.19.389726 IC50 1.28 direct 20221018
Imatinib 10.1101/2020.06.18.158196 IC50 130 nm direct 20221018
Itraconazole 10.1101/2020.11.13.381194 EC50 3.6 direct 20221018
Ivermectin 10.1016/j.mehy.2020.110364 IC50 10 direct 20221018
Ivermectin 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Ivermectin 10.1101/2021.11.01.466865 EC50 1 direct 20221018
Ivermectin 10.1101/2020.04.21.20073262 IC50 2 um direct 20221018
Lapatinib 10.1371/journal.pone.0269563 IC50 35 um direct 20220711
Lercanidipine 10.1101/2020.08.28.271957 IC50 40 direct 20221018
Liquiritin 10.1101/2020.05.02.074021 EC50 2.39 um direct 20221018
Lopinavir 10.26434/chemrxiv.11829102.v1 IC50 is approximately 50 micromolar direct 20221018
Lopinavir 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Lopinavir 10.26434/chemrxiv.11829102.v2 IC50 is approximately 50 micromolar direct 20221018
Lopinavir 10.1101/2020.04.29.20085761 EC50 5.48 um direct 20221018
Lopinavir 10.1016/j.ejps.2020.105631 EC50 5.48 um direct 20221018
Lysine 10.1101/2021.02.19.424337 IC50 70 nm direct 20221018
Manidipine 10.1101/2020.08.28.271957 IC50 40 direct 20221018
Mefloquine 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Mefloquine 10.1101/2020.11.19.389726 IC50 1.28 direct 20221018
Mefloquine 10.1101/2021.07.21.451321 EC50 1.2 um direct 20221018
Melittin 10.1101/2021.10.21.465254 EC50 1.571 direct 20221018
Merimepodib 10.1101/2021.12.18.473303 IC50 4 micro direct 20221018
Moxidectin 10.1101/2021.11.01.466865 EC50 2 direct 20221018
Nafamostat 10.1101/2020.05.12.090035 IC50 0.0022 micro direct 20221018
Nafamostat 10.1101/2020.06.23.167544 IC50 0.27 nm direct 20221018
Nafamostat 10.1101/2020.04.22.054981 EC50 10 nm direct 20221018
Narlaprevir 10.1101/2020.07.10.197889 EC50 1.1 direct 20221018
Narlaprevir 10.1101/2020.12.02.408112 EC50 40 um direct 20221018
Nelfinavir 10.1101/2020.04.06.026476 EC50 1.13 micro direct 20221018
Nelfinavir 10.1101/2020.06.22.165712 EC50 0.77 direct 20221018
Nelfinavir 10.1101/2020.04.16.20068379 EC50 3.1 direct 20221018
Nevirapine 10.1101/2020.06.26.174698 IC50 1 direct 20221018
Nitazoxanide 10.1101/2022.07.13.499346 IC50 0.05 direct 20221018
Nitazoxanide 10.1101/2020.09.24.312165 EC50 4.9 direct 20221018
Nitazoxanide 10.1016/s2055-6640(20)30017-0 EC50 14 direct 20221018
Omeprazol 10.1101/2020.04.03.023846 EC50 20 micro direct 20221018
Opipramol 10.1101/2020.04.03.023846 EC50 20 micro direct 20221018
Papain 10.21203/rs.3.rs-33294/v1 IC50 19 direct 20221018
Paritaprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Pralatrexate 10.21203/rs.3.rs-36439/v1 EC50 0.008 um direct 20221018
Protoporphyrin 10.1101/2020.04.30.071290 EC50 at nanomolar concentrations direct 20221018
Ptc299 10.1101/2020.08.05.238394 EC50 2 nm direct 20221018
Pyronaridine 10.1101/2020.12.01.407361 IC50 180 nm direct 20221018
Pyronaridine 10.1101/2021.09.30.462449 IC50 1.8 micro direct 20221018
Quinidine 10.1101/2020.04.03.023846 EC50 20 micro direct 20221018
Remdesivir 10.1101/2020.04.27.064279 EC50 0.01 direct 20221018
Remdesivir 10.1101/2020.08.28.267567 IC50 0.29 direct 20221018
Remdesivir 10.1101/2020.05.27.117184 IC50 308 nm direct 20221018
Remdesivir 10.1101/2021.07.03.450938 IC50 9.3 direct 20221018
Remdesivir 10.1101/2021.12.03.471068 IC50 0.37 um direct 20221018
Remdesivir 10.1101/2021.03.02.433604 IC50 1.5 micro direct 20221018
Remdesivir 10.1101/2020.06.22.165712 EC50 1.32 direct 20221018
Remdesivir 10.1101/2021.09.07.459230 IC50 0.15 micro direct 20221018
Remdesivir 10.1016/j.ijid.2020.05.085 EC50 0.38 um direct 20221018
Remdesivir 10.1093/jac/dkaa239 EC50 1 direct 20221018
Remdesivir 10.1101/2020.04.03.20052548 EC50 0.38 direct 20221018
Remdesivir 10.2139/ssrn.3588829 EC50 0.01 um direct 20221018
Remdesivir 10.1101/2022.07.23.501242 EC50 31.8 nm direct 20221018
Remdesivir 10.1101/2020.11.13.381194 EC50 0.4 um direct 20221018
Remdesivir 10.1101/2020.11.12.380394 EC50 0.5 direct 20221018
Remdesivir 10.1101/2020.12.02.408112 EC50 1 direct 20221018
Ribavirin 10.33250/14.02.106 EC50 0 ug direct 20221018
Ritonavir 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Rottlerin 10.1101/2021.03.02.433618 IC50 37 direct 20221018
Rupintrivir 10.1101/2020.06.22.165712 EC50 0.77 direct 20221018
Selamectin 10.1101/2021.11.01.466865 EC50 2 direct 20221018
Simeprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Sinefungin 10.1101/2020.07.30.228478 IC50 286 nm direct 20221018
Siramesine 10.1101/2020.08.29.273441 IC50 3 direct 20221018
Sofosbuvir 10.1101/2020.06.15.153411 EC50 6.2 direct 20221018
Sulfadoxine 10.1101/2020.04.16.20068379 EC50 3.1 direct 20221018
Sulfate 10.1101/2020.04.14.041459 IC50 0.056 direct 20221018
Suramin 10.1101/2020.08.29.273441 IC50 3 direct 20221018
Suramin 10.1101/2020.07.17.207019 IC50 0.26 um direct 20221018
Suramin 10.1101/2020.08.28.270306 IC50 30 direct 20221018
Suramin 10.1101/2020.05.06.081968 EC50 20 micro direct 20221018
Tafenoquine 10.1101/2020.07.12.199059 EC50 2.6 um direct 20221018
Teicoplanin 10.1101/2020.02.05.935387 IC50 1.66 um direct 20221018
Telaprevir 10.1101/2020.07.10.197889 EC50 1.1 direct 20221018
Telaprevir 10.1101/2020.12.02.408112 EC50 40 um direct 20221018
Tipranavir 10.1101/2020.04.16.20068379 EC50 50 direct 20221018
Tropifexor 10.1101/2021.12.02.471030 EC50 4.03 micro direct 20221018
Tropifexor 10.1101/2021.12.02.471030 IC50 3.39 micro direct 20221010
Tyrosine 10.1101/2020.06.18.158196 IC50 130 nm direct 20221018
Tyrosine 10.1101/2021.12.16.472155 IC50 0.79 um direct 20221018
Vandetanib 10.1101/2021.12.16.472155 IC50 0.79 um direct 20221018
Vaniprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Verteporfin 10.1101/2020.04.30.071290 EC50 at nanomolar concentrations direct 20221018
Vortioxetine 10.1101/2020.06.05.135996 IC50 0.34 um direct 20221018
Voxilaprevir 10.1101/2020.12.02.408112 EC50 15 direct 20221018
Water 10.1101/2021.01.08.425825 IC50 0.1 direct 20221018
Zncl2 10.1042/BCJ20220380 IC50 2 um direct 20221018
Znso4 10.1042/BCJ20220380 IC50 2 um direct 20221018
Acetamide 10.33250/14.02.106 EC50 0 ug indirect 20221018
Alanine 10.1101/2021.12.18.473330 EC50 1 um indirect 20221018
Angiotensin 10.1101/2021.11.24.469776 IC50 sub - nanomolar ic50 indirect 20221018
Angiotensin 10.1101/2022.04.26.489529 IC50 0.1 micro indirect 20221018
Angiotensin 10.1101/2022.05.10.491295 EC50 8 nm indirect 20221018
Angiotensin 10.1101/2021.08.10.455627 IC50 2022 indirect 20221018
Angiotensin 10.1101/2021.08.05.21261616 IC50 0.83 indirect 20221018
Angiotensin 10.1101/2022.07.30.501940 IC50 64 nm indirect 20221018
Angiotensin 10.1371/journal.ppat.1010799 EC50 8 nm indirect 20221018
Angiotensin 10.1101/2021.06.04.447130 IC50 15 indirect 20221018
Angiotensin 10.1101/2021.05.17.444533 IC50 0.4 indirect 20221018
Angiotensin 10.1101/2020.06.18.158196 IC50 130 nm indirect 20221018
Angiotensin 10.1101/2020.06.08.140236 IC50 599 indirect 20221018
Angiotensin 10.1186/s12967-020-02435-4 IC50 2 indirect 20221018
Angiotensin 10.1101/2021.01.07.425806 IC50 60 indirect 20221018
Angiotensin 10.1101/2020.07.31.231746 IC50 10 indirect 20221018
Angiotensin 10.1101/2020.04.19.049643 IC50 12 nm indirect 20221018
Angiotensin 10.1101/2020.08.08.242511 IC50 4 nm indirect 20221018
Angiotensin 10.1101/2020.07.24.219857 EC50 1.1 nm indirect 20221018
Angiotensin 10.1101/2020.12.02.408153 IC50 735 nm indirect 20221018
Angiotensin 10.1101/2020.09.14.295956 IC50 113.2 indirect 20221018
Angiotensin 10.1101/2020.08.24.264077 IC50 in the nanomolar range indirect 20221018
Angiotensin 10.1101/2020.04.02.021725 IC50 2 indirect 20221018
Angiotensin 10.1101/2020.09.22.308338 IC50 in the low nanomolar range indirect 20221018
Angiotensin 10.1101/2020.09.16.20190694 EC50 1 nm indirect 20221018
Anisomycin 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Apilimod 10.1101/2020.06.26.174698 IC50 1 indirect 20221018
Atovaquone 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Azithromycin 10.1101/2020.05.21.108605 IC50 237 um indirect 20221018
Baicalin 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Baricitinib 10.1101/2021.12.16.472155 IC50 0.79 um indirect 20221018
Benzophenone 10.1371/journal.pone.0240079 IC50 0.2 um indirect 20221018
Bepridil 10.1101/2021.06.08.447613 EC50 1 um indirect 20221018
Bepridil 10.1101/2020.05.23.112235 IC50 100 um indirect 20221018
Biopterin 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Boceprevir 10.1101/2021.06.08.447613 EC50 1 um indirect 20221018
Boceprevir 10.1101/2021.12.18.473330 EC50 1 um indirect 20221018
Boceprevir 10.1101/2020.12.19.423537 EC50 1.27 micro indirect 20221018
Calcium 10.1101/2020.12.13.420406 EC50 0.1 um indirect 20221018
Calcium 10.1042/BCJ20220380 IC50 2 um indirect 20221018
Camostat 10.1101/2020.04.22.054981 EC50 10 nm indirect 20221018
Camostat 10.21203/rs.3.rs-34021/v1 EC50 96 indirect 20221018
Camostat 10.1101/2021.05.06.442935 EC50 430 nm indirect 20221018
Carbamide 10.1101/2021.12.18.473330 EC50 1 um indirect 20221018
Carrageenan 10.1039/d0fo02017f IC50 9.1 ug indirect 20221018
Carrageenan 10.1101/2020.08.23.255364 EC50 0.3 indirect 20221018
Cepharanthine 10.1101/2020.12.13.420406 EC50 0.1 um indirect 20221018
Chicken 10.1101/2020.11.29.401984 EC50 0.147 nm indirect 20221018
Chloroquine 10.1101/2021.06.08.447613 EC50 1 um indirect 20221018
Chloroquine 10.1101/2021.07.21.451321 EC50 1.2 um indirect 20221018
Chloroquine 10.1101/2020.04.23.055756 IC50 25 um indirect 20221018
Chloroquine 10.1101/2020.04.03.023846 EC50 20 micro indirect 20221018
Chloroquine 10.1101/2020.03.25.008482 IC50 at non - cytotoxic concentrations indirect 20221018
Chloroquine 10.1101/2020.05.16.091520 EC50 2 indirect 20221018
Chloroquine 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Chloroquine 10.1016/j.mehy.2020.109783 EC50 0.72 um indirect 20221018
Chlorpromazine 10.1101/2020.03.25.008482 IC50 at non - cytotoxic concentrations indirect 20221018
Chlorpromazine 10.1101/2020.05.05.079608 IC50 10 indirect 20221018
Chymotrypsin 10.1101/2020.03.22.20034041 IC50 0.29 nm indirect 20221018
Chymotrypsin 10.1101/2020.05.28.120642 IC50 3 indirect 20221018
Chymotrypsin 10.1101/2021.03.19.435806 IC50 29 indirect 20221018
Ciclesonide 10.1101/2020.03.20.999730 IC50 10 indirect 20221018
Cobicistat 10.1101/2020.04.03.20052548 EC50 100 indirect 20221018
Cobicistat 10.1016/j.ijid.2020.05.085 EC50 100 um indirect 20221018
Conivaptan 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Copper 10.1101/2021.09.17.460613 EC50 154 nm indirect 20221018
Cotton 10.1101/2021.01.17.426875 EC50 100 nm indirect 20221018
Cucumber 10.1039/d0fo02017f IC50 9.1 ug indirect 20221018
Cysteine 10.1101/2020.12.23.424111 IC50 in the picomolar range None indirect 20221010
Cysteine 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Cysteine 10.1101/2021.02.13.431008 IC50 10 micro indirect 20221018
Cysteine 10.1101/2022.07.06.498864 IC50 0.3 micro indirect 20221010
Cysteine 10.1101/2021.12.18.473326 IC50 4.8 nm indirect 20221018
Cysteine 10.1101/2020.10.23.347534 EC50 74 nm indirect 20221018
Cysteine 10.1101/2022.07.06.498864 EC50 3.1 micro indirect 20221018
Cysteine 10.1101/2020.07.28.223784 IC50 100 nm indirect 20221018
Cysteine 10.1101/2020.05.20.107052 IC50 in the nanomolar range indirect 20221018
Cysteine 10.1371/journal.pone.0240079 IC50 0.2 um indirect 20221018
Cysteine 10.1101/2021.06.04.447160 IC50 60 um indirect 20221018
Cysteine 10.1101/2020.07.17.208959 IC50 2.1 um indirect 20221018
Cysteine 10.1101/2020.09.21.299776 IC50 155 nm indirect 20221018
Cysteine 10.1101/2020.05.28.120642 IC50 3 indirect 20221018
Cysteine 10.1042/BCJ20220380 IC50 2 um indirect 20221018
Cysteine 10.1101/2020.12.23.424111 EC50 in the nanomolar range indirect 20221018
Daclatasvir 10.1101/2020.06.15.153411 EC50 6.2 indirect 20221018
Darunavir 10.1101/2020.04.03.20052548 EC50 100 indirect 20221018
Darunavir 10.1016/j.ijid.2020.05.085 EC50 100 um indirect 20221018
Dexamethasone 10.1101/2021.12.16.472155 IC50 0.79 um indirect 20221018
Dihydromyricetin 10.1101/2021.07.01.450756 IC50 0.125 um indirect 20221018
Dihydroquercetin 10.1101/2021.07.01.450756 IC50 0.125 um indirect 20221018
Ebastine 10.1101/2020.05.23.112235 IC50 100 um indirect 20221018
Ebselen 10.1101/2020.02.26.964882 IC50 0.67 um indirect 20221018
Ebselen 10.1101/2021.06.08.447613 EC50 1 um indirect 20221018
Ebselen 10.1101/2020.05.20.107052 IC50 in the nanomolar range indirect 20221018
Emetine 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Emetine 10.1101/2020.11.29.401984 EC50 0.147 nm indirect 20221018
Emtricitabine 10.1101/2020.06.22.165712 EC50 1.32 indirect 20221018
Ethanol 10.1101/2020.04.10.035824 EC50 0.74 indirect 20221018
Ethanol 10.1101/2020.04.10.035824 IC50 0.39 um indirect 20221010
Favipiravir 10.1101/2021.03.25.436935 IC50 1 indirect 20221018
Fenofibrate 10.1101/2020.04.23.055756 IC50 25 um indirect 20221018
Fluoxetine 10.1101/2020.06.14.150490 EC50 387 indirect 20221018
Fucoidan 10.1039/d0fo02017f IC50 9.1 ug indirect 20221018
Fucose 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Fucose 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Galactose 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Galactose 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Galactose 10.1101/2021.10.27.466067 EC50 0.9 indirect 20221018
Gemcitabine 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Glucose 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Glucose 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Glutamine 10.1101/2020.02.10.936898 EC50 low - micromolar ec50 values indirect 20221018
Glutamine 10.1101/2021.08.23.457419 EC50 in the low micromolar range indirect 20221018
Glycine 10.1101/2021.12.18.473330 EC50 1 um indirect 20221018
Guanosine 10.1101/2021.02.19.424337 IC50 70 nm indirect 20221018
Heparin 10.1111/bph.15304 IC50 25 ug indirect 20221018
Hernandezine 10.1101/2020.12.13.420406 EC50 0.1 um indirect 20221018
Histamine 10.1101/2020.09.15.296228 EC50 6 indirect 20221018
Homoharringtonine 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Huangqin 10.1101/2020.04.10.035824 EC50 0.74 indirect 20221018
Huangqin 10.1101/2020.04.10.035824 IC50 0.39 um indirect 20221010
Hydrogen 10.1101/2021.09.06.459055 IC50 0.41 indirect 20221018
Hydrogen 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Hydroxychloroquine 10.30651/jqm.v4i2.4998 EC50 1 um indirect 20221018
Hydroxychloroquine 10.1101/2020.05.23.112235 IC50 100 um indirect 20221018
Hydroxychloroquine 10.1101/2020.05.16.091520 EC50 2 indirect 20221018
Hydroxychloroquine 10.1016/j.mehy.2020.109783 EC50 0.72 um indirect 20221018
Hydroxychloroquine 10.1101/2021.06.08.447613 EC50 1 um indirect 20221018
Hydroxychloroquine 10.1101/2020.09.16.299537 EC50 10 indirect 20221018
Hydroxychloroquine 10.1101/2020.05.21.108605 IC50 237 um indirect 20221018
Hydroxychloroquine 10.1101/2020.07.05.20146878 EC50 indicated insufficient lpv concentrations indirect 20221018
Hydroxychloroquine 10.1101/2021.07.21.451321 EC50 1.2 um indirect 20221018
Irbesartan 10.1101/2022.07.23.501242 EC50 1.24 micro indirect 20221018
Isoquercetin 10.1101/2021.07.01.450756 IC50 0.125 um indirect 20221018
Kaempferol 10.1101/2021.07.01.450756 IC50 0.125 um indirect 20221018
Ledipasvir 10.1101/2020.06.22.165712 EC50 1.32 indirect 20221018
Leflunomide 10.1101/2020.03.11.983056 EC50 17 nm indirect 20221018
Lenvatinib 10.1101/2021.03.19.435806 IC50 29 indirect 20221018
Leucine 10.1101/2021.08.23.457419 EC50 in the low micromolar range indirect 20221018
Licorice 10.1101/2020.05.02.074021 EC50 2.39 um indirect 20221018
Lopinavir 10.1101/2020.04.06.026476 EC50 1.13 micro indirect 20221018
Lopinavir 10.1101/2020.07.05.20146878 EC50 indicated insufficient lpv concentrations indirect 20221018
Lopinavir 10.30651/jqm.v4i2.4998 EC50 1 um indirect 20221018
Luteolin 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Magnesium 10.1042/BCJ20220380 IC50 2 um indirect 20221018
Manganese 10.1042/BCJ20220380 IC50 2 um indirect 20221018
Mannose 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Mannose 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Masitinib 10.1101/2020.08.31.274639 EC50 0.1 micro indirect 20221018
Myricetin 10.1101/2020.12.16.422677 IC50 1 indirect 20221018
Neferine 10.1101/2020.12.13.420406 EC50 0.1 um indirect 20221018
Nelfinavir 10.1101/2020.04.23.055756 IC50 25 um indirect 20221018
Nelfinavir 10.1101/2020.11.19.389726 IC50 1.28 indirect 20221018
Niclosamide 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Niclosamide 10.1101/2020.03.20.999730 IC50 10 indirect 20221018
Nitazoxanide 10.1101/2020.04.16.20068379 EC50 of the concentration - response curve indirect 20221018
Nitazoxanide 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Nystatin 10.1101/2022.07.23.501242 EC50 1.24 micro indirect 20221018
Oleandrin 10.1101/2020.07.15.203489 EC50 11.98 indirect 20221018
Orange 10.6084/m9.figshare.19783635.v1 IC50 3 None indirect 20220715
Orange 10.6084/m9.figshare.19783635.v1 EC50 3 None indirect 20220714
Oseltamivir 10.1101/2020.03.11.983056 EC50 17 nm indirect 20221018
Papain 10.25417/uic.19719751.v1 IC50 3 None indirect 20220714
Papain 10.1101/2020.10.23.347534 EC50 74 nm indirect 20221018
Papain 10.1101/2020.05.20.107052 IC50 in the nanomolar range indirect 20221018
Papain 10.1101/2021.03.15.435551 EC50 8.89 micro indirect 20221018
Papain 10.1101/2021.06.04.447160 IC50 60 um indirect 20221018
Papain 10.1101/2021.12.02.471030 EC50 4.03 micro indirect 20221018
Papain 10.1101/2022.01.05.475095 IC50 0.41 micro indirect 20221018
Papain 10.1042/BCJ20220380 IC50 2 um indirect 20221018
Papain 10.1101/2021.03.15.435551 IC50 at the single - digit micromolar range None indirect 20221010
Papain 10.1101/2021.12.02.471030 IC50 3.39 micro indirect 20221010
Papain 10.1101/2020.07.17.208959 IC50 2.1 um indirect 20221018
Papain 10.1101/2021.02.13.431008 IC50 10 micro indirect 20221018
Pazopanib 10.1101/2021.03.19.435806 IC50 29 indirect 20221018
Pectin 10.1101/2021.10.27.466067 EC50 0.9 indirect 20221018
Phenothiazine 10.1101/2020.08.29.273441 IC50 3 indirect 20221018
Phenothiazine 10.1101/2020.05.05.079608 IC50 10 indirect 20221018
Phosphate 10.1016/j.mehy.2020.109783 EC50 0.72 um indirect 20221018
Phosphate 10.1093/cid/ciaa237 EC50 0.72 um indirect 20221018
Phospholipids 10.1101/2021.01.12.426042 IC50 0.06 indirect 20221018
Pimozide 10.1101/2020.05.23.112235 IC50 100 um indirect 20221018
Plitidepsin 10.1101/2020.04.23.055756 IC50 25 um indirect 20221018
Proline 10.1101/2021.02.17.431647 IC50 1 indirect 20221018
Quercetin 10.1101/2021.07.01.450756 IC50 0.125 um indirect 20221018
Quercetin 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Remdesivir 10.1101/2021.03.25.436935 IC50 1 indirect 20221018
Remdesivir 10.21203/rs.3.rs-36439/v1 EC50 0.008 um indirect 20221018
Remdesivir 10.1101/2020.06.26.174698 IC50 1 indirect 20221018
Remdesivir 10.1101/2021.01.08.425825 IC50 0.1 indirect 20221018
Remdesivir 10.1101/2020.12.29.424534 EC50 769.1 indirect 20221018
Remdesivir 10.1101/2021.09.30.462449 IC50 1.8 micro indirect 20221018
Remdesivir 10.1101/2020.12.01.407361 IC50 180 nm indirect 20221018
Remdesivir 10.1101/2020.11.19.389726 IC50 1.28 indirect 20221018
Remdesivir 10.1101/2020.10.28.359042 EC50 0.08 indirect 20221018
Remdesivir 10.1101/2020.09.16.299537 EC50 10 indirect 20221018
Remdesivir 10.1101/2021.04.02.438204 IC50 1 um indirect 20221018
Remdesivir 10.1101/2021.12.16.472155 IC50 0.79 um indirect 20221018
Remdesivir 10.1101/2022.02.09.479840 EC50 0.31 indirect 20221018
Remdesivir 10.1101/2020.04.23.055756 IC50 25 um indirect 20221018
Remdesivir 10.1101/2022.02.07.479493 EC50 50 indirect 20221018
Remdesivir 10.1101/2021.03.19.435806 IC50 29 indirect 20221018
Remdesivir 10.1101/2021.11.03.467186 EC50 4.1 indirect 20221018
Resveratrol 10.1101/2021.04.29.442010 IC50 0.11 um indirect 20221018
Rhamnose 10.1101/2021.10.27.466067 EC50 0.9 indirect 20221018
Rhamnose 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Rhamnose 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Ribose 10.1101/2021.11.03.467186 EC50 4.1 indirect 20221018
Ritonavir 10.30651/jqm.v4i2.4998 EC50 1 um indirect 20221018
Ritonavir 10.1101/2020.07.05.20146878 EC50 indicated insufficient lpv concentrations indirect 20221018
Ritonavir 10.1101/2020.03.22.20034041 IC50 0.29 nm indirect 20221018
Rutin 10.21203/rs.3.rs-33294/v1 IC50 19 indirect 20221018
Rutin 10.1101/2021.07.01.450756 IC50 0.125 um indirect 20221018
Salinomycin 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Serine 10.1101/2021.05.06.442935 EC50 430 nm indirect 20221018
Serine 10.21203/rs.3.rs-34021/v1 EC50 96 indirect 20221018
Serine 10.21203/rs.3.rs-34021/v4 EC50 96 indirect 20221018
Serine 10.21203/rs.3.rs-34021/v5 EC50 96 indirect 20221018
Serotonin 10.1101/2020.06.14.150490 EC50 387 indirect 20221018
Sofosbuvir 10.1101/2020.06.22.165712 EC50 1.32 indirect 20221018
Sulfate 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Sulfate 10.1101/2020.05.10.087288 IC50 38 nm indirect 20221018
Sulfate 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Sulfate 10.30651/jqm.v4i2.4998 EC50 1 um indirect 20221018
Sulfate 10.1101/2020.08.20.260190 EC50 0.09 indirect 20221018
Sulfate 10.1101/2020.06.08.140236 IC50 599 indirect 20221018
Sulfate 10.1039/d0fo02017f IC50 9.1 ug indirect 20221018
Sulfate 10.1093/cid/ciaa237 EC50 0.72 um indirect 20221018
Sunitinib 10.1101/2021.03.19.435806 IC50 29 indirect 20221018
Tenofovir 10.1101/2020.06.22.165712 EC50 1.32 indirect 20221018
Teriflunomide 10.1101/2020.03.11.983056 EC50 17 nm indirect 20221018
Thein 10.1101/2020.11.29.401984 EC50 0.147 nm indirect 20221018
Thimerosal 10.1371/journal.pone.0240079 IC50 0.2 um indirect 20221018
Threonine 10.1101/2021.12.18.473330 EC50 1 um indirect 20221018
Threonine 10.1101/2021.12.18.473326 IC50 4.8 nm indirect 20221018
Tocilizumab 10.1101/2020.07.05.20146878 EC50 indicated insufficient lpv concentrations indirect 20221018
Trypsin 10.1101/2020.06.23.167544 IC50 0.27 nm indirect 20221018
Tryptophan 10.1042/BCJ20220380 IC50 2 um indirect 20221018
Tyrosine 10.1101/2020.08.31.274639 EC50 0.1 micro indirect 20221018
Tyrosine 10.1101/2021.03.19.435806 IC50 29 indirect 20221018
Valinomycin 10.1016/j.bj.2020.05.003 EC50 11 nm indirect 20221018
Velpatasvir 10.1101/2020.06.22.165712 EC50 1.32 indirect 20221018
Water 10.1101/2020.12.29.424534 EC50 769.1 indirect 20221018
Water 10.1101/2021.09.08.459260 IC50 0.3 indirect 20221018
Xylose 10.1101/2021.01.14.426521 IC50 0.48 None indirect 20221010
Xylose 10.1101/2021.01.14.426521 EC50 2.01 indirect 20221018
Yeast 10.1101/2021.01.07.425806 IC50 60 indirect 20221018
Yeast 10.1101/2020.07.31.231746 IC50 10 indirect 20221018

We are making our best efforts to collect SARS-CoV-2 in vitro experimental results from recent publications. This dataset will be updated continuously.

Last Updated: November 10, 2020

Rank_ID Drug Name SARS-CoV-2 EC50/IC50(μM) CC50(μM) SI
1 Nafamostat 0.0022 >25 11363
2 Amuvatinib 0.02 0.06 3
3 Apilimod 0.023 N/A N/A
4 Apilimod 0.023 N/A N/A
5 Carboxyamidotriazole 0.09 0.11 1.22
6 Ouabain 0.097 50 515.5
7 Pristimerin 0.11 1.1 10.00
8 Z-FA-FMK 0.13 N/A N/A
9 VBY -825 0.14 N/A N/A
10 MLN-3897 0.14 N/A N/A
11 Digitoxin 0.16 >50 312.5
12 Digoxin 0.19 >50 256.61
13 AI-10-49 0.19 6.58 34.63
14 Z LVG CHN2 0.19 N/A N/A
15 Tyrphostin 0.2 1.36 6.8
16 CAA-0225 0.2 N/A N/A
17 Polidocanol 0.22 10.3 46.82
18 MDL 28170 0.22 N/A N/A
19 Digitoxin 0.23 >50 214.1
20 Salinomycin sodium 0.24 >50 >211
21 VLX600 0.24 0.06 0.25
22 GSK2606414 0.25 70.35 281.4
23 Cathepsin Inhibitor 1 0.25 N/A N/A
24 SL-11128 0.25 N/A N/A
25 Niclosamide 0.28 >50 176.65
26 VBY -825 0.3 N/A N/A
27 Emetine 0.46 56.46 122.74
28 Salinomycin sodium 0.5 >50 100
29 Calpeptin 0.5 N/A N/A
30 ONO 5334 0.5 N/A N/A
31 Alvocidib 0.59 0.06 0.1
32 Cetylpyridinium chloride 0.62 0.66 1.06
33 Remdesivir 0.62 N/A N/A
34 Pevonedistat 0.63 222.44 353.08
35 VPS34-IN1 0.63 10 15.87
36 Ethaverine 0.64 11.04 17.25
37 Camostat 0.64 >20 >31.25
38 Berzosertib 0.71 11.1 15.63
39 Digoxin 0.72 >50 69.4
40 Dapivirine 0.73 5 6.85
41 SDZ-62-434 0.75 N/A N/A
42 Remdesivir 0.77 >100 >129.87
43 AC1NDSS5 0.77 0.89 1.16
44 SB-612111 0.77 3.67 4.77
45 Thioguanosine 0.78 0.63 0.81
46 Niclosamide 0.84 >50 59.5
47 LY2228820 0.87 56.2 64.6
48 Hexachlorophene 0.9 19.3 21.55
49 AMG-2674 0.95 N/A N/A
50 YH-1238 0.95 N/A N/A
51 Papaverine 1.1 4.49 4.08
52 STF-62247 1.1 11.2 10.18
53 Hanfangchin A 1.1 N/A N/A
54 Elopiprazole 1.1 N/A N/A
55 Astemizole 1.1 N/A N/A
56 Chloroquine 1.13 >100 >88.5
57 Nelfinavir 1.13 24.32 21.52
58 SB-616234-A 1.2 N/A N/A
59 KW 8232 1.2 N/A N/A
60 N-tert-Butylisoquine 1.2 N/A N/A
61 Remdesivir 1.3 >50 38.5
62 Z-Gly-Leu-Phe-chloromethyl ketone 1.3 N/A N/A
63 ZK-93423 1.34 0.91 0.68
64 VPS34 Inhibitor 1 1.4 N/A N/A
65 Almitrine 1.42 102.2 71.97
66 Hexachlorophene 1.48 >50 33.8
67 Auranofin 1.5 low toxicity N/A
68 Sorafenib 1.55 1.17 0.75
69 8-(3-Chlorostyryl) caffeine 1.6 N/A N/A
70 Posaconazole 1.61 14.64 9.09
71 Octenidine 1.65 2.4 1.45
72 Regorafenib 1.67 0.97 0.58
73 Thimerosal 1.69 13.52 8
74 Tioguanine 1.71 2.21 1.29
75 Hematoporphyrin 1.85 160.08 86.53
76 Chlormidazole 1.89 0.88 0.47
77 Ivermectin 2 low toxicity N/A
78 Balicatib 2 N/A N/A
79 Calpain 2 N/A N/A
80 Methylene blue 2.03 7.25 3.57
81 Proscillaridin 2.04 >50 >24.54
82 Nitazoxanide 2.12 35.53 >16.76
83 Azithromycine 2.12 >40 >19
84 Ketoconazole 2.36 28.62 12.13
85 alpha-L- Arabinopyrano se 2.4 N/A N/A
86 Homoharringtonine 2.55 59.75 23.43
87 Ravuconazole 2.76 12.75 4.62
88 LDK378 2.86 6.84 2.39
89 Tetrandrine 3 14.92 4.97
90 Alisporivir 3.1 >20 >6.45
91 ML414 3.2 N/A N/A
92 Isoosajin 3.22 9.89 3.07
93 Osimertinib mesylate 3.26 13.23 4.05
94 LGK-974 3.27 7.61 2.33
95 Mibampator 3.28 8.66 2.64
96 Bazedoxifene 3.44 14.97 4.35
97 MCOPPB 3.5 N/A N/A
98 GW 803430 3.5 N/A N/A
99 IT1t dihydrochloride 3.5 N/A N/A
100 Oxyclozanide 3.71 >50 >13.49
101 Lusutrombopag 3.78 14.61 3.87
102 S-15176 difumarate salt 3.8 N/A N/A
103 Osajin 3.87 11.44 2.95
104 Hydroxyprogesterone caproate 3.87 >50 12.9
105 Dronedarone HCl 3.92 8.75 2.23
106 Avasimibe 3.93 13.71 3.49
107 Amodiaquin dihydrochloride 4 N/A N/A
108 Chlorpromazine Hydrochloride 4.03 11.88 2.94
109 Tilorone 4.09 19.67 4.81
110 Hydroxychloroquine Sulfate 4.17 >40 >10
111 Ciclesonide 4.33 >50 >11.56
112 Cepharanthine 4.47 >50 >11.18
113 N- Methylspiperon e hydrochloride 4.5 N/A N/A
114 Isopomiferin 4.51 14.25 3.16
115 Anidulafugin 4.64 >50 >10.78
116 Ebselen 4.67 low toxicity N/A
117 Cyclosporine 4.69 >50 10.5
118 Amodiaquin Dihydrochloride Dihydrate 4.94 34.42 6.97
119 Penfluridol 5.01 8.77 1.75
120 Opipramol dihydrochloride 5.05 >40 >7.9
121 Quinacrine hydrochloride monohydrate 5.11 >40 >7.8
122 CVL218 5.12 91.05 17.78
123 Amodiaquine hydrochloride 5.15 >50 >9.71
124 Imatinib Mesylate 5.32 >30.86 >5.80
125 Fluspirilene 5.32 30.33 5.71
126 Clomiphene Citrate 5.36 15.01 2.8
127 Alprostadil 5.39 >40 >7.4
128 Pexidartinib 5.43 41.53 7.65
129 JTV519 Hemifumarate 5.5 N/A N/A
130 Amodiaquin Hydrochloride 5.64 >38.63 >6.84
131 Lonafarnib 5.68 10.71 1.89
132 Avatrombopag 5.71 20.86 3.65
133 Cyclosporine 5.82 >50 >8.59
134 Apixaban 5.91 18.07 3.06
135 Proscillaridin 5.95 >50 8.4
136 IPAG 5.96 11.48 1.93
137 JTE-013 5.97 16.45 2.76
138 Drotaverine 6.07 9 1.48
139 Hydroxyprogesterone caproate 6.3 >50 7.93
140 Perhexiline maleate 6.38 8.67 1.36
141 Triparanol 6.41 21.21 3.31
142 Ivacaftor 6.57 12.47 1.9
143 Droloxifene((E)-3-Hydroxy tamoxifen) 6.6 15.82 2.4
144 Abemaciclib 6.62 >50 >7.56
145 Thioridazine hydrochloride 6.69 15.96 2.39
146 Gilteritinib 6.76 37.16 5.5
147 Oxyclozanide 6.78 >50 7.37
148 Ebastine 6.92 15.42 2.23
149 Triparanol 7.05 14.73 2.09
150 IKK-2 Inhibitor VIII 7.1 N/A N/A
151 Mequitazine 7.28 27.34 3.76
152 Clomipramine Hydrochloride 7.59 >29.68 >3.91
153 Berbamine hydrochloride 7.87 >50 >6.35
154 Clemastine fumarate 7.9 N/A N/A
155 GMC 2-29 7.9 N/A N/A
156 Thiethylperazine Maleate 8.02 18.37 2.29
157 Mefloquine Hydrochloride 8.06 18.53 2.3
158 Eltrombopag 8.27 >50 >6.05
159 Eltrombopag 8.38 48.85 5.83
160 Saquinavir 8.83 44.43 5.03
161 NSC 33994 8.9 N/A N/A
162 Rescimetol 8.9 N/A N/A
163 Fluphenazine Dihydrochloride 8.98 20.02 2.23
164 Tamoxifen Citrate 8.98 37.96 4.23
165 Lopinavir 9.12 >50 >5.18
166 Loperamide 9.27 29.26 3.16
167 Atazanavir 9.36 >81 >8.65
168 Lu AE58054 hydrochloride Chlorprothixen e 10 N/A N/A
169 Methdilazine hydrochloride 10 N/A N/A
170 Methotrimepra zine maleate 10 N/A N/A
171 Piperacetazine 10 N/A N/A
172 Difeterol 10 N/A N/A
173 (R)-(-)-L Y 426965 dihydrochloride Loperamide hydrochloride 10 N/A N/A
174 Naltrindole isothiocyanate hydrochloride 10 N/A N/A
175 AM1241 10 N/A N/A
176 CpdD hydrochloride 10 N/A N/A
177 SB 271046 hydrochloride 10 N/A N/A
178 GMC 2-113 10 N/A N/A
179 Imatinib 10 N/A N/A
180 Duloxetine hydrochloride 10 N/A N/A
181 Trifluomeprazi ne 2- butenedioate Asteriscunolide D Genz-123346 (free base) 10 N/A N/A
182 Maprotiline hydrochloride 10 N/A N/A
183 Deserpidine 10 N/A N/A
184 Amiodarone hydrochloride 10 N/A N/A
185 Melitracen hydrochloride 10 N/A N/A
186 (+/-) - Fluoxetine 10 N/A N/A
187 Flunarizine 10 N/A N/A
188 Proglumetacin DMP 777 Dexanabinol 10 N/A N/A
189 Promethazine Hydrochloride 10.44 >42.59 >4.08
190 Ciclesonide 10.64 >50 4.7
191 LDE225 10.67 2.26 0.21
192 Arbidol 10.7 >40 >3.7
193 Toremifene Citrate 11.3 20.51 1.81
194 Ivacaftor 11.55 30.38 2.63
195 N-(2-hydroxypropyl)-3-trimethylammonium 46chitosan chloride 12.5 158 12.6
196 Loperamide hydrochloride 12.53 47.4 3.78
197 Bazedoxifene 12.63 27.84 2.2
198 DCPIB 12.78 24.55 1.92
199 Tipranavir 13.34 76.8 5.76
200 Dihydrogambogic acid 13.37 9.85 0.74
201 Tetrandrine 13.5 22.3 1.71
202 AMG-9810 14.97 14.22 0.95
203 Loratadine 15.13 28.33 1.87
204 Brexpiprazole 16.04 50.57 3.15
205 Erconazole Vetranal 16.14 41.46 2.57
206 N3 16.77 >133 >7.93
207 CC-223 16.78 9.49 0.57
208 CBIPES 17.05 13.4 0.79
209 Omeprazole 17.06 >40 >2.35
210 Anidulafungin 17.23 >50 2.9
211 Lidoflazine 17.39 31.91 1.83
212 Benztropine Mesylate 17.79 >50 >2.81
213 Loteprednol etabonate 17.92 49.03 2.74
214 Vatalanib 18.27 64.18 3.51
215 Adoprazine 18.59 75.9 4.08
216 PH-797804 18.85 19.97 1.06
217 Cloconazole 18.92 33 1.74
218 BP-897 18.95 30.03 1.58
219 Harringtonine 19 0.07 0
220 Flunarizine 19.05 136.76 7.18
221 PF-670462 19.23 8.24 0.43
222 Oxprenolol hydrochloride 20.22 >40 >2
223 Etifoxine 20.64 43.53 2.11
224 Oxiconazole 20.82 26.36 1.27
225 Lopinavir 21.7 >50 2.3
226 Dolutegravir 22.04 >40 >1.8
227 Nafamostat 22.5 >100 >4.44
228 Clemizole hydrochloride 23.94 >40 >1.7
229 Phenazopyridine 28 >50 >1.79
230 Cepharanthine 30 >50 1.67
231 Amprenavir 31.32 >81 >2.59
232 Sulfadoxine 35.37 >40 >1.13
233 Abemaciclib 43.7 >50 1.1
234 Darunavir 46.41 >81 >1.75
235 Chloroquine Phosphate 46.8 >50 >1.07
236 Indinavir 59.14 >81 >1.37
237 Favipiravir 61.88 >400 >6.46
238 Chloroquine 69.2 >250 3.6
239 Penciclovir 95.96 >400 >4.17
240 Remdesivir 100 N/A N/A
241 Ribavirin 109.5 >400 >3.65
242 Lanatoside C >50 >50 1
243 Quinacrine hydrochloride >50 14.71 <0.29
244 Berbamine hydrochloride >50 >50 1
245 Gilteritinib >50 >50 1
246 Amodiaquine dihydrochloride >50 >50 1
247 Mefloquine >50 >50 1
248 Ouabain <0.1 >50 633
249 NSC319726 <0.02 <0.02 1
  • Cell lines and assay conditions used in various studies may be different.
  • The current table is ranked by potency.

Reference:

  1. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell research, 2020, 30(3): 269-271.

  2. A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19. bioRxiv, 2020.

  3. FDA approved drugs with broad anti-coronaviral activity inhibit SARS-CoV-2 in vitro. bioRxiv, 2020.

  4. HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV, bioRxiv, 2020.

  5. Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs, bioRxiv, 2020.

  6. The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro

  7. Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro

  8. Structure of Mpro from COVID-19 virus and discovery of its inhibitors

  9. Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

  10. The FDA- approved gold drug Auranofin inhibits novel coronavirus (SARS- COV-2) replication and attenuates inflammation in human cells

  11. Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection

  12. In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

  13. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate

  14. Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

  15. A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals


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