COVID-19临床前研究
临床前体外研究
以下是已发表体外实验结果的更新研究列表。使用与SARS-CoV-2和COVID-19相关的几个众所周知的预印本和出版物数据库进行研究。使用简单的NLP脚本以及相关标记提取药物名称和EC50/IC50数值结果。间接相关意味着尽管提取了药物名称，但使用我们当前的算法无法将其映射到实验值。需要注意的是，该列表仅用作进一步研究的参考，药物名称和提取的数值既不100%准确也不完整。
Last Updated: October 18, 2022
| Drug name | DOI | Assay | Value | Units | Correlation | Date Added |
|---|---|---|---|---|---|---|
| Acetamide | 10.1080/10426507.2020.1828886 | EC50 | 9.8 | um | direct | 20221018 |
| Acrylamide | 10.1101/2020.09.21.299776 | IC50 | low micromolar ic50 | direct | 20221018 | |
| Adenosine | 10.1101/2020.04.27.064279 | EC50 | 0.01 | direct | 20221018 | |
| Adenosine | 10.2139/ssrn.3588829 | EC50 | 0.01 | um | direct | 20221018 |
| Amodiaquine | 10.1101/2021.01.08.425825 | IC50 | 5.8 | um | direct | 20221018 |
| Amprenavir | 10.1101/2020.06.26.174698 | IC50 | 1 | direct | 20221018 | |
| Andrographolide | 10.21203/rs.3.rs-24311/v1 | EC50 | 10 | um | direct | 20221018 |
| Arbidol | 10.1016/j.ejps.2020.105631 | EC50 | 5.48 | um | direct | 20221018 |
| Arbidol | 10.1101/2020.04.29.20085761 | EC50 | 5.48 | um | direct | 20221018 |
| Artemether | 10.1101/2020.10.05.326637 | EC50 | 7 | direct | 20221018 | |
| Artemether | 10.1101/2021.01.08.425825 | IC50 | 70 | micro | direct | 20221018 |
| Artemisinin | 10.1101/2020.10.05.326637 | EC50 | 7 | direct | 20221018 | |
| Artemisinin | 10.1101/2022.07.22.501141 | IC50 | 0.5 | micro | direct | 20221018 |
| Artemisinin | 10.1101/2021.09.08.459260 | IC50 | 0.3 | direct | 20221018 | |
| Artemisinin | 10.1101/2021.01.08.425825 | IC50 | 0.1 | direct | 20221018 | |
| Artesunate | 10.1101/2020.10.05.326637 | EC50 | 7 | direct | 20221018 | |
| Artesunate | 10.1101/2021.01.08.425825 | IC50 | 70 | micro | direct | 20221018 |
| Asenapine | 10.1101/2020.06.05.135996 | IC50 | 0.34 | um | direct | 20221018 |
| Astodrimer | 10.1101/2020.08.20.260190 | EC50 | 0.09 | direct | 20221018 | |
| Asunaprevir | 10.1101/2020.12.02.408112 | EC50 | 72 | direct | 20221018 | |
| Atazanavir | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Auranofin | 10.1101/2020.05.28.120642 | IC50 | 3 | direct | 20221018 | |
| Azelastine | 10.1101/2020.09.15.296228 | EC50 | 6 | direct | 20221018 | |
| Azithromycin | 10.21203/rs.3.rs-36439/v1 | EC50 | 0.008 | um | direct | 20221018 |
| Azithromycin | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Azithromycine | 10.1101/2020.04.03.023846 | EC50 | 20 | micro | direct | 20221018 |
| Baicalein | 10.1101/2020.04.10.035824 | IC50 | 0.39 | um | direct | 20221018 |
| Baloxavir | 10.1016/j.ejps.2020.105631 | EC50 | 5.48 | um | direct | 20221018 |
| Baloxavir | 10.1101/2020.04.29.20085761 | EC50 | 5.48 | um | direct | 20221018 |
| Bedaquiline | 10.1101/2020.08.28.271957 | IC50 | 40 | direct | 20221018 | |
| Boceprevir | 10.1101/2020.12.02.408112 | EC50 | 40 | um | direct | 20221018 |
| Boceprevir | 10.1101/2020.04.20.051581 | IC50 | submicromolar ic50 values | None | direct | 20221010 |
| Boceprevir | 10.1101/2020.07.10.197889 | EC50 | 0.95 | direct | 20221018 | |
| Boceprevir | 10.1101/2020.04.20.051581 | EC50 | 0.49 | um | direct | 20221018 |
| Boceprevir | 10.1101/2020.08.28.271957 | IC50 | 40 | direct | 20221018 | |
| Bortezomib | 10.1016/j.arcmed.2020.10.002 | IC50 | 47 | direct | 20221018 | |
| Camostat | 10.1101/2020.06.23.167544 | IC50 | 0.27 | nm | direct | 20221018 |
| Camostat | 10.21203/rs.3.rs-34021/v4 | EC50 | 26000 | direct | 20221018 | |
| Camostat | 10.21203/rs.3.rs-34021/v5 | EC50 | 26000 | direct | 20221018 | |
| Carbon | 10.1101/2021.12.18.473326 | IC50 | 3 | direct | 20221018 | |
| Carmofur | 10.1101/2020.04.09.033233 | EC50 | 24.3 | direct | 20221018 | |
| Ceftazidime | 10.1101/2020.09.14.295956 | IC50 | 113.2 | direct | 20221018 | |
| Chloroquine | 10.1101/2020.08.29.273441 | IC50 | 3 | direct | 20221018 | |
| Chloroquine | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Chloroquine | 10.30651/jqm.v4i2.4998 | EC50 | 1 | um | direct | 20221018 |
| Chloroquine | 10.1093/cid/ciaa237 | EC50 | 0.72 | um | direct | 20221018 |
| Chloroquine | 10.1101/2020.06.22.165712 | EC50 | 1.32 | direct | 20221018 | |
| Chymotrypsin | 10.1101/2020.12.16.422677 | IC50 | 1 | direct | 20221018 | |
| Ciluprevir | 10.1101/2020.07.10.197889 | EC50 | 0.95 | direct | 20221018 | |
| Clomiphene | 10.1101/2020.06.05.135996 | IC50 | 0.34 | um | direct | 20221018 |
| Cobicistat | 10.1101/2020.06.22.165712 | EC50 | 0.77 | direct | 20221018 | |
| Danoprevir | 10.1101/2020.03.22.20034041 | IC50 | 0.29 | nm | direct | 20221018 |
| Danoprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Diclazuril | 10.1101/2021.03.19.435806 | IC50 | 29 | direct | 20221018 | |
| Dihydroartemisinin | 10.1101/2021.01.08.425825 | IC50 | 70 | micro | direct | 20221018 |
| Dipyridamole | 10.1101/2020.02.27.20027557 | EC50 | 100 | nm | direct | 20221018 |
| Disulfiram | 10.1101/2021.09.17.460613 | EC50 | 154 | nm | direct | 20221018 |
| Efonidipine | 10.1101/2020.08.28.271957 | IC50 | 40 | direct | 20221018 | |
| Enoxaparin | 10.1101/2020.06.08.140236 | IC50 | 599 | direct | 20221018 | |
| Faldaprevir | 10.1101/2020.12.02.408112 | EC50 | 72 | direct | 20221018 | |
| Favipiravir | 10.1016/j.ejps.2020.105631 | EC50 | 5.48 | um | direct | 20221018 |
| Favipiravir | 10.1101/2020.04.29.20085761 | EC50 | 5.48 | um | direct | 20221018 |
| Favipiravir | 10.21203/rs.3.rs-24311/v1 | EC50 | 10 | um | direct | 20221018 |
| Gabexate | 10.1101/2020.06.23.167544 | IC50 | 0.27 | nm | direct | 20221018 |
| Galidesivir | 10.1101/2021.03.25.436935 | IC50 | 1 | direct | 20221018 | |
| Glecaprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Gramicidin | 10.1101/2021.10.21.465254 | EC50 | 1.571 | direct | 20221018 | |
| Grazoprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Heparin | 10.1101/2020.05.10.087288 | IC50 | 38 | nm | direct | 20221018 |
| Heparin | 10.1101/2020.05.21.107870 | IC50 | 0.05 | direct | 20221018 | |
| Heparin | 10.1101/2020.06.08.140236 | IC50 | 599 | direct | 20221018 | |
| Heparin | 10.1101/2020.04.14.041459 | IC50 | 0.056 | direct | 20221018 | |
| Honokiol | 10.1101/2022.07.26.501656 | EC50 | 7.8 | micro | direct | 20221018 |
| Hopeaphenol | 10.1101/2021.04.29.442010 | IC50 | 0.11 | um | direct | 20221018 |
| Hydroxocobalamin | 10.1101/2020.07.17.207019 | IC50 | 0.26 | um | direct | 20221018 |
| Hydroxychloroquine | 10.1093/cid/ciaa623 | EC50 | to the free plasma hydroxychloroquine concentration | direct | 20221018 | |
| Hydroxychloroquine | 10.1101/2020.07.12.199059 | EC50 | 2.6 | direct | 20221018 | |
| Hydroxychloroquine | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Hydroxychloroquine | 10.1093/cid/ciaa237 | EC50 | 0.72 | um | direct | 20221018 |
| Hydroxychloroquine | 10.1101/2020.11.19.389726 | IC50 | 1.28 | direct | 20221018 | |
| Imatinib | 10.1101/2020.06.18.158196 | IC50 | 130 | nm | direct | 20221018 |
| Itraconazole | 10.1101/2020.11.13.381194 | EC50 | 3.6 | direct | 20221018 | |
| Ivermectin | 10.1016/j.mehy.2020.110364 | IC50 | 10 | direct | 20221018 | |
| Ivermectin | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Ivermectin | 10.1101/2021.11.01.466865 | EC50 | 1 | direct | 20221018 | |
| Ivermectin | 10.1101/2020.04.21.20073262 | IC50 | 2 | um | direct | 20221018 |
| Lapatinib | 10.1371/journal.pone.0269563 | IC50 | 35 | um | direct | 20220711 |
| Lercanidipine | 10.1101/2020.08.28.271957 | IC50 | 40 | direct | 20221018 | |
| Liquiritin | 10.1101/2020.05.02.074021 | EC50 | 2.39 | um | direct | 20221018 |
| Lopinavir | 10.26434/chemrxiv.11829102.v1 | IC50 | is approximately 50 micromolar | direct | 20221018 | |
| Lopinavir | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Lopinavir | 10.26434/chemrxiv.11829102.v2 | IC50 | is approximately 50 micromolar | direct | 20221018 | |
| Lopinavir | 10.1101/2020.04.29.20085761 | EC50 | 5.48 | um | direct | 20221018 |
| Lopinavir | 10.1016/j.ejps.2020.105631 | EC50 | 5.48 | um | direct | 20221018 |
| Lysine | 10.1101/2021.02.19.424337 | IC50 | 70 | nm | direct | 20221018 |
| Manidipine | 10.1101/2020.08.28.271957 | IC50 | 40 | direct | 20221018 | |
| Mefloquine | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Mefloquine | 10.1101/2020.11.19.389726 | IC50 | 1.28 | direct | 20221018 | |
| Mefloquine | 10.1101/2021.07.21.451321 | EC50 | 1.2 | um | direct | 20221018 |
| Melittin | 10.1101/2021.10.21.465254 | EC50 | 1.571 | direct | 20221018 | |
| Merimepodib | 10.1101/2021.12.18.473303 | IC50 | 4 | micro | direct | 20221018 |
| Moxidectin | 10.1101/2021.11.01.466865 | EC50 | 2 | direct | 20221018 | |
| Nafamostat | 10.1101/2020.05.12.090035 | IC50 | 0.0022 | micro | direct | 20221018 |
| Nafamostat | 10.1101/2020.06.23.167544 | IC50 | 0.27 | nm | direct | 20221018 |
| Nafamostat | 10.1101/2020.04.22.054981 | EC50 | 10 | nm | direct | 20221018 |
| Narlaprevir | 10.1101/2020.07.10.197889 | EC50 | 1.1 | direct | 20221018 | |
| Narlaprevir | 10.1101/2020.12.02.408112 | EC50 | 40 | um | direct | 20221018 |
| Nelfinavir | 10.1101/2020.04.06.026476 | EC50 | 1.13 | micro | direct | 20221018 |
| Nelfinavir | 10.1101/2020.06.22.165712 | EC50 | 0.77 | direct | 20221018 | |
| Nelfinavir | 10.1101/2020.04.16.20068379 | EC50 | 3.1 | direct | 20221018 | |
| Nevirapine | 10.1101/2020.06.26.174698 | IC50 | 1 | direct | 20221018 | |
| Nitazoxanide | 10.1101/2022.07.13.499346 | IC50 | 0.05 | direct | 20221018 | |
| Nitazoxanide | 10.1101/2020.09.24.312165 | EC50 | 4.9 | direct | 20221018 | |
| Nitazoxanide | 10.1016/s2055-6640(20)30017-0 | EC50 | 14 | direct | 20221018 | |
| Omeprazol | 10.1101/2020.04.03.023846 | EC50 | 20 | micro | direct | 20221018 |
| Opipramol | 10.1101/2020.04.03.023846 | EC50 | 20 | micro | direct | 20221018 |
| Papain | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | direct | 20221018 | |
| Paritaprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Pralatrexate | 10.21203/rs.3.rs-36439/v1 | EC50 | 0.008 | um | direct | 20221018 |
| Protoporphyrin | 10.1101/2020.04.30.071290 | EC50 | at nanomolar concentrations | direct | 20221018 | |
| Ptc299 | 10.1101/2020.08.05.238394 | EC50 | 2 | nm | direct | 20221018 |
| Pyronaridine | 10.1101/2020.12.01.407361 | IC50 | 180 | nm | direct | 20221018 |
| Pyronaridine | 10.1101/2021.09.30.462449 | IC50 | 1.8 | micro | direct | 20221018 |
| Quinidine | 10.1101/2020.04.03.023846 | EC50 | 20 | micro | direct | 20221018 |
| Remdesivir | 10.1101/2020.04.27.064279 | EC50 | 0.01 | direct | 20221018 | |
| Remdesivir | 10.1101/2020.08.28.267567 | IC50 | 0.29 | direct | 20221018 | |
| Remdesivir | 10.1101/2020.05.27.117184 | IC50 | 308 | nm | direct | 20221018 |
| Remdesivir | 10.1101/2021.07.03.450938 | IC50 | 9.3 | direct | 20221018 | |
| Remdesivir | 10.1101/2021.12.03.471068 | IC50 | 0.37 | um | direct | 20221018 |
| Remdesivir | 10.1101/2021.03.02.433604 | IC50 | 1.5 | micro | direct | 20221018 |
| Remdesivir | 10.1101/2020.06.22.165712 | EC50 | 1.32 | direct | 20221018 | |
| Remdesivir | 10.1101/2021.09.07.459230 | IC50 | 0.15 | micro | direct | 20221018 |
| Remdesivir | 10.1016/j.ijid.2020.05.085 | EC50 | 0.38 | um | direct | 20221018 |
| Remdesivir | 10.1093/jac/dkaa239 | EC50 | 1 | direct | 20221018 | |
| Remdesivir | 10.1101/2020.04.03.20052548 | EC50 | 0.38 | direct | 20221018 | |
| Remdesivir | 10.2139/ssrn.3588829 | EC50 | 0.01 | um | direct | 20221018 |
| Remdesivir | 10.1101/2022.07.23.501242 | EC50 | 31.8 | nm | direct | 20221018 |
| Remdesivir | 10.1101/2020.11.13.381194 | EC50 | 0.4 | um | direct | 20221018 |
| Remdesivir | 10.1101/2020.11.12.380394 | EC50 | 0.5 | direct | 20221018 | |
| Remdesivir | 10.1101/2020.12.02.408112 | EC50 | 1 | direct | 20221018 | |
| Ribavirin | 10.33250/14.02.106 | EC50 | 0 | ug | direct | 20221018 |
| Ritonavir | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Rottlerin | 10.1101/2021.03.02.433618 | IC50 | 37 | direct | 20221018 | |
| Rupintrivir | 10.1101/2020.06.22.165712 | EC50 | 0.77 | direct | 20221018 | |
| Selamectin | 10.1101/2021.11.01.466865 | EC50 | 2 | direct | 20221018 | |
| Simeprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Sinefungin | 10.1101/2020.07.30.228478 | IC50 | 286 | nm | direct | 20221018 |
| Siramesine | 10.1101/2020.08.29.273441 | IC50 | 3 | direct | 20221018 | |
| Sofosbuvir | 10.1101/2020.06.15.153411 | EC50 | 6.2 | direct | 20221018 | |
| Sulfadoxine | 10.1101/2020.04.16.20068379 | EC50 | 3.1 | direct | 20221018 | |
| Sulfate | 10.1101/2020.04.14.041459 | IC50 | 0.056 | direct | 20221018 | |
| Suramin | 10.1101/2020.08.29.273441 | IC50 | 3 | direct | 20221018 | |
| Suramin | 10.1101/2020.07.17.207019 | IC50 | 0.26 | um | direct | 20221018 |
| Suramin | 10.1101/2020.08.28.270306 | IC50 | 30 | direct | 20221018 | |
| Suramin | 10.1101/2020.05.06.081968 | EC50 | 20 | micro | direct | 20221018 |
| Tafenoquine | 10.1101/2020.07.12.199059 | EC50 | 2.6 | um | direct | 20221018 |
| Teicoplanin | 10.1101/2020.02.05.935387 | IC50 | 1.66 | um | direct | 20221018 |
| Telaprevir | 10.1101/2020.07.10.197889 | EC50 | 1.1 | direct | 20221018 | |
| Telaprevir | 10.1101/2020.12.02.408112 | EC50 | 40 | um | direct | 20221018 |
| Tipranavir | 10.1101/2020.04.16.20068379 | EC50 | 50 | direct | 20221018 | |
| Tropifexor | 10.1101/2021.12.02.471030 | EC50 | 4.03 | micro | direct | 20221018 |
| Tropifexor | 10.1101/2021.12.02.471030 | IC50 | 3.39 | micro | direct | 20221010 |
| Tyrosine | 10.1101/2020.06.18.158196 | IC50 | 130 | nm | direct | 20221018 |
| Tyrosine | 10.1101/2021.12.16.472155 | IC50 | 0.79 | um | direct | 20221018 |
| Vandetanib | 10.1101/2021.12.16.472155 | IC50 | 0.79 | um | direct | 20221018 |
| Vaniprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Verteporfin | 10.1101/2020.04.30.071290 | EC50 | at nanomolar concentrations | direct | 20221018 | |
| Vortioxetine | 10.1101/2020.06.05.135996 | IC50 | 0.34 | um | direct | 20221018 |
| Voxilaprevir | 10.1101/2020.12.02.408112 | EC50 | 15 | direct | 20221018 | |
| Water | 10.1101/2021.01.08.425825 | IC50 | 0.1 | direct | 20221018 | |
| Zncl2 | 10.1042/BCJ20220380 | IC50 | 2 | um | direct | 20221018 |
| Znso4 | 10.1042/BCJ20220380 | IC50 | 2 | um | direct | 20221018 |
| Acetamide | 10.33250/14.02.106 | EC50 | 0 | ug | indirect | 20221018 |
| Alanine | 10.1101/2021.12.18.473330 | EC50 | 1 | um | indirect | 20221018 |
| Angiotensin | 10.1101/2021.11.24.469776 | IC50 | sub - nanomolar ic50 | indirect | 20221018 | |
| Angiotensin | 10.1101/2022.04.26.489529 | IC50 | 0.1 | micro | indirect | 20221018 |
| Angiotensin | 10.1101/2022.05.10.491295 | EC50 | 8 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2021.08.10.455627 | IC50 | 2022 | indirect | 20221018 | |
| Angiotensin | 10.1101/2021.08.05.21261616 | IC50 | 0.83 | indirect | 20221018 | |
| Angiotensin | 10.1101/2022.07.30.501940 | IC50 | 64 | nm | indirect | 20221018 |
| Angiotensin | 10.1371/journal.ppat.1010799 | EC50 | 8 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2021.06.04.447130 | IC50 | 15 | indirect | 20221018 | |
| Angiotensin | 10.1101/2021.05.17.444533 | IC50 | 0.4 | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.06.18.158196 | IC50 | 130 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2020.06.08.140236 | IC50 | 599 | indirect | 20221018 | |
| Angiotensin | 10.1186/s12967-020-02435-4 | IC50 | 2 | indirect | 20221018 | |
| Angiotensin | 10.1101/2021.01.07.425806 | IC50 | 60 | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.07.31.231746 | IC50 | 10 | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.04.19.049643 | IC50 | 12 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2020.08.08.242511 | IC50 | 4 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2020.07.24.219857 | EC50 | 1.1 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2020.12.02.408153 | IC50 | 735 | nm | indirect | 20221018 |
| Angiotensin | 10.1101/2020.09.14.295956 | IC50 | 113.2 | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.08.24.264077 | IC50 | in the nanomolar range | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.04.02.021725 | IC50 | 2 | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.09.22.308338 | IC50 | in the low nanomolar range | indirect | 20221018 | |
| Angiotensin | 10.1101/2020.09.16.20190694 | EC50 | 1 | nm | indirect | 20221018 |
| Anisomycin | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Apilimod | 10.1101/2020.06.26.174698 | IC50 | 1 | indirect | 20221018 | |
| Atovaquone | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Azithromycin | 10.1101/2020.05.21.108605 | IC50 | 237 | um | indirect | 20221018 |
| Baicalin | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Baricitinib | 10.1101/2021.12.16.472155 | IC50 | 0.79 | um | indirect | 20221018 |
| Benzophenone | 10.1371/journal.pone.0240079 | IC50 | 0.2 | um | indirect | 20221018 |
| Bepridil | 10.1101/2021.06.08.447613 | EC50 | 1 | um | indirect | 20221018 |
| Bepridil | 10.1101/2020.05.23.112235 | IC50 | 100 | um | indirect | 20221018 |
| Biopterin | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Boceprevir | 10.1101/2021.06.08.447613 | EC50 | 1 | um | indirect | 20221018 |
| Boceprevir | 10.1101/2021.12.18.473330 | EC50 | 1 | um | indirect | 20221018 |
| Boceprevir | 10.1101/2020.12.19.423537 | EC50 | 1.27 | micro | indirect | 20221018 |
| Calcium | 10.1101/2020.12.13.420406 | EC50 | 0.1 | um | indirect | 20221018 |
| Calcium | 10.1042/BCJ20220380 | IC50 | 2 | um | indirect | 20221018 |
| Camostat | 10.1101/2020.04.22.054981 | EC50 | 10 | nm | indirect | 20221018 |
| Camostat | 10.21203/rs.3.rs-34021/v1 | EC50 | 96 | indirect | 20221018 | |
| Camostat | 10.1101/2021.05.06.442935 | EC50 | 430 | nm | indirect | 20221018 |
| Carbamide | 10.1101/2021.12.18.473330 | EC50 | 1 | um | indirect | 20221018 |
| Carrageenan | 10.1039/d0fo02017f | IC50 | 9.1 | ug | indirect | 20221018 |
| Carrageenan | 10.1101/2020.08.23.255364 | EC50 | 0.3 | indirect | 20221018 | |
| Cepharanthine | 10.1101/2020.12.13.420406 | EC50 | 0.1 | um | indirect | 20221018 |
| Chicken | 10.1101/2020.11.29.401984 | EC50 | 0.147 | nm | indirect | 20221018 |
| Chloroquine | 10.1101/2021.06.08.447613 | EC50 | 1 | um | indirect | 20221018 |
| Chloroquine | 10.1101/2021.07.21.451321 | EC50 | 1.2 | um | indirect | 20221018 |
| Chloroquine | 10.1101/2020.04.23.055756 | IC50 | 25 | um | indirect | 20221018 |
| Chloroquine | 10.1101/2020.04.03.023846 | EC50 | 20 | micro | indirect | 20221018 |
| Chloroquine | 10.1101/2020.03.25.008482 | IC50 | at non - cytotoxic concentrations | indirect | 20221018 | |
| Chloroquine | 10.1101/2020.05.16.091520 | EC50 | 2 | indirect | 20221018 | |
| Chloroquine | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Chloroquine | 10.1016/j.mehy.2020.109783 | EC50 | 0.72 | um | indirect | 20221018 |
| Chlorpromazine | 10.1101/2020.03.25.008482 | IC50 | at non - cytotoxic concentrations | indirect | 20221018 | |
| Chlorpromazine | 10.1101/2020.05.05.079608 | IC50 | 10 | indirect | 20221018 | |
| Chymotrypsin | 10.1101/2020.03.22.20034041 | IC50 | 0.29 | nm | indirect | 20221018 |
| Chymotrypsin | 10.1101/2020.05.28.120642 | IC50 | 3 | indirect | 20221018 | |
| Chymotrypsin | 10.1101/2021.03.19.435806 | IC50 | 29 | indirect | 20221018 | |
| Ciclesonide | 10.1101/2020.03.20.999730 | IC50 | 10 | indirect | 20221018 | |
| Cobicistat | 10.1101/2020.04.03.20052548 | EC50 | 100 | indirect | 20221018 | |
| Cobicistat | 10.1016/j.ijid.2020.05.085 | EC50 | 100 | um | indirect | 20221018 |
| Conivaptan | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Copper | 10.1101/2021.09.17.460613 | EC50 | 154 | nm | indirect | 20221018 |
| Cotton | 10.1101/2021.01.17.426875 | EC50 | 100 | nm | indirect | 20221018 |
| Cucumber | 10.1039/d0fo02017f | IC50 | 9.1 | ug | indirect | 20221018 |
| Cysteine | 10.1101/2020.12.23.424111 | IC50 | in the picomolar range | None | indirect | 20221010 |
| Cysteine | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Cysteine | 10.1101/2021.02.13.431008 | IC50 | 10 | micro | indirect | 20221018 |
| Cysteine | 10.1101/2022.07.06.498864 | IC50 | 0.3 | micro | indirect | 20221010 |
| Cysteine | 10.1101/2021.12.18.473326 | IC50 | 4.8 | nm | indirect | 20221018 |
| Cysteine | 10.1101/2020.10.23.347534 | EC50 | 74 | nm | indirect | 20221018 |
| Cysteine | 10.1101/2022.07.06.498864 | EC50 | 3.1 | micro | indirect | 20221018 |
| Cysteine | 10.1101/2020.07.28.223784 | IC50 | 100 | nm | indirect | 20221018 |
| Cysteine | 10.1101/2020.05.20.107052 | IC50 | in the nanomolar range | indirect | 20221018 | |
| Cysteine | 10.1371/journal.pone.0240079 | IC50 | 0.2 | um | indirect | 20221018 |
| Cysteine | 10.1101/2021.06.04.447160 | IC50 | 60 | um | indirect | 20221018 |
| Cysteine | 10.1101/2020.07.17.208959 | IC50 | 2.1 | um | indirect | 20221018 |
| Cysteine | 10.1101/2020.09.21.299776 | IC50 | 155 | nm | indirect | 20221018 |
| Cysteine | 10.1101/2020.05.28.120642 | IC50 | 3 | indirect | 20221018 | |
| Cysteine | 10.1042/BCJ20220380 | IC50 | 2 | um | indirect | 20221018 |
| Cysteine | 10.1101/2020.12.23.424111 | EC50 | in the nanomolar range | indirect | 20221018 | |
| Daclatasvir | 10.1101/2020.06.15.153411 | EC50 | 6.2 | indirect | 20221018 | |
| Darunavir | 10.1101/2020.04.03.20052548 | EC50 | 100 | indirect | 20221018 | |
| Darunavir | 10.1016/j.ijid.2020.05.085 | EC50 | 100 | um | indirect | 20221018 |
| Dexamethasone | 10.1101/2021.12.16.472155 | IC50 | 0.79 | um | indirect | 20221018 |
| Dihydromyricetin | 10.1101/2021.07.01.450756 | IC50 | 0.125 | um | indirect | 20221018 |
| Dihydroquercetin | 10.1101/2021.07.01.450756 | IC50 | 0.125 | um | indirect | 20221018 |
| Ebastine | 10.1101/2020.05.23.112235 | IC50 | 100 | um | indirect | 20221018 |
| Ebselen | 10.1101/2020.02.26.964882 | IC50 | 0.67 | um | indirect | 20221018 |
| Ebselen | 10.1101/2021.06.08.447613 | EC50 | 1 | um | indirect | 20221018 |
| Ebselen | 10.1101/2020.05.20.107052 | IC50 | in the nanomolar range | indirect | 20221018 | |
| Emetine | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Emetine | 10.1101/2020.11.29.401984 | EC50 | 0.147 | nm | indirect | 20221018 |
| Emtricitabine | 10.1101/2020.06.22.165712 | EC50 | 1.32 | indirect | 20221018 | |
| Ethanol | 10.1101/2020.04.10.035824 | EC50 | 0.74 | indirect | 20221018 | |
| Ethanol | 10.1101/2020.04.10.035824 | IC50 | 0.39 | um | indirect | 20221010 |
| Favipiravir | 10.1101/2021.03.25.436935 | IC50 | 1 | indirect | 20221018 | |
| Fenofibrate | 10.1101/2020.04.23.055756 | IC50 | 25 | um | indirect | 20221018 |
| Fluoxetine | 10.1101/2020.06.14.150490 | EC50 | 387 | indirect | 20221018 | |
| Fucoidan | 10.1039/d0fo02017f | IC50 | 9.1 | ug | indirect | 20221018 |
| Fucose | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Fucose | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Galactose | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Galactose | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Galactose | 10.1101/2021.10.27.466067 | EC50 | 0.9 | indirect | 20221018 | |
| Gemcitabine | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Glucose | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Glucose | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Glutamine | 10.1101/2020.02.10.936898 | EC50 | low - micromolar ec50 values | indirect | 20221018 | |
| Glutamine | 10.1101/2021.08.23.457419 | EC50 | in the low micromolar range | indirect | 20221018 | |
| Glycine | 10.1101/2021.12.18.473330 | EC50 | 1 | um | indirect | 20221018 |
| Guanosine | 10.1101/2021.02.19.424337 | IC50 | 70 | nm | indirect | 20221018 |
| Heparin | 10.1111/bph.15304 | IC50 | 25 | ug | indirect | 20221018 |
| Hernandezine | 10.1101/2020.12.13.420406 | EC50 | 0.1 | um | indirect | 20221018 |
| Histamine | 10.1101/2020.09.15.296228 | EC50 | 6 | indirect | 20221018 | |
| Homoharringtonine | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Huangqin | 10.1101/2020.04.10.035824 | EC50 | 0.74 | indirect | 20221018 | |
| Huangqin | 10.1101/2020.04.10.035824 | IC50 | 0.39 | um | indirect | 20221010 |
| Hydrogen | 10.1101/2021.09.06.459055 | IC50 | 0.41 | indirect | 20221018 | |
| Hydrogen | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Hydroxychloroquine | 10.30651/jqm.v4i2.4998 | EC50 | 1 | um | indirect | 20221018 |
| Hydroxychloroquine | 10.1101/2020.05.23.112235 | IC50 | 100 | um | indirect | 20221018 |
| Hydroxychloroquine | 10.1101/2020.05.16.091520 | EC50 | 2 | indirect | 20221018 | |
| Hydroxychloroquine | 10.1016/j.mehy.2020.109783 | EC50 | 0.72 | um | indirect | 20221018 |
| Hydroxychloroquine | 10.1101/2021.06.08.447613 | EC50 | 1 | um | indirect | 20221018 |
| Hydroxychloroquine | 10.1101/2020.09.16.299537 | EC50 | 10 | indirect | 20221018 | |
| Hydroxychloroquine | 10.1101/2020.05.21.108605 | IC50 | 237 | um | indirect | 20221018 |
| Hydroxychloroquine | 10.1101/2020.07.05.20146878 | EC50 | indicated insufficient lpv concentrations | indirect | 20221018 | |
| Hydroxychloroquine | 10.1101/2021.07.21.451321 | EC50 | 1.2 | um | indirect | 20221018 |
| Irbesartan | 10.1101/2022.07.23.501242 | EC50 | 1.24 | micro | indirect | 20221018 |
| Isoquercetin | 10.1101/2021.07.01.450756 | IC50 | 0.125 | um | indirect | 20221018 |
| Kaempferol | 10.1101/2021.07.01.450756 | IC50 | 0.125 | um | indirect | 20221018 |
| Ledipasvir | 10.1101/2020.06.22.165712 | EC50 | 1.32 | indirect | 20221018 | |
| Leflunomide | 10.1101/2020.03.11.983056 | EC50 | 17 | nm | indirect | 20221018 |
| Lenvatinib | 10.1101/2021.03.19.435806 | IC50 | 29 | indirect | 20221018 | |
| Leucine | 10.1101/2021.08.23.457419 | EC50 | in the low micromolar range | indirect | 20221018 | |
| Licorice | 10.1101/2020.05.02.074021 | EC50 | 2.39 | um | indirect | 20221018 |
| Lopinavir | 10.1101/2020.04.06.026476 | EC50 | 1.13 | micro | indirect | 20221018 |
| Lopinavir | 10.1101/2020.07.05.20146878 | EC50 | indicated insufficient lpv concentrations | indirect | 20221018 | |
| Lopinavir | 10.30651/jqm.v4i2.4998 | EC50 | 1 | um | indirect | 20221018 |
| Luteolin | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Magnesium | 10.1042/BCJ20220380 | IC50 | 2 | um | indirect | 20221018 |
| Manganese | 10.1042/BCJ20220380 | IC50 | 2 | um | indirect | 20221018 |
| Mannose | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Mannose | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Masitinib | 10.1101/2020.08.31.274639 | EC50 | 0.1 | micro | indirect | 20221018 |
| Myricetin | 10.1101/2020.12.16.422677 | IC50 | 1 | indirect | 20221018 | |
| Neferine | 10.1101/2020.12.13.420406 | EC50 | 0.1 | um | indirect | 20221018 |
| Nelfinavir | 10.1101/2020.04.23.055756 | IC50 | 25 | um | indirect | 20221018 |
| Nelfinavir | 10.1101/2020.11.19.389726 | IC50 | 1.28 | indirect | 20221018 | |
| Niclosamide | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Niclosamide | 10.1101/2020.03.20.999730 | IC50 | 10 | indirect | 20221018 | |
| Nitazoxanide | 10.1101/2020.04.16.20068379 | EC50 | of the concentration - response curve | indirect | 20221018 | |
| Nitazoxanide | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Nystatin | 10.1101/2022.07.23.501242 | EC50 | 1.24 | micro | indirect | 20221018 |
| Oleandrin | 10.1101/2020.07.15.203489 | EC50 | 11.98 | indirect | 20221018 | |
| Orange | 10.6084/m9.figshare.19783635.v1 | IC50 | 3 | None | indirect | 20220715 |
| Orange | 10.6084/m9.figshare.19783635.v1 | EC50 | 3 | None | indirect | 20220714 |
| Oseltamivir | 10.1101/2020.03.11.983056 | EC50 | 17 | nm | indirect | 20221018 |
| Papain | 10.25417/uic.19719751.v1 | IC50 | 3 | None | indirect | 20220714 |
| Papain | 10.1101/2020.10.23.347534 | EC50 | 74 | nm | indirect | 20221018 |
| Papain | 10.1101/2020.05.20.107052 | IC50 | in the nanomolar range | indirect | 20221018 | |
| Papain | 10.1101/2021.03.15.435551 | EC50 | 8.89 | micro | indirect | 20221018 |
| Papain | 10.1101/2021.06.04.447160 | IC50 | 60 | um | indirect | 20221018 |
| Papain | 10.1101/2021.12.02.471030 | EC50 | 4.03 | micro | indirect | 20221018 |
| Papain | 10.1101/2022.01.05.475095 | IC50 | 0.41 | micro | indirect | 20221018 |
| Papain | 10.1042/BCJ20220380 | IC50 | 2 | um | indirect | 20221018 |
| Papain | 10.1101/2021.03.15.435551 | IC50 | at the single - digit micromolar range | None | indirect | 20221010 |
| Papain | 10.1101/2021.12.02.471030 | IC50 | 3.39 | micro | indirect | 20221010 |
| Papain | 10.1101/2020.07.17.208959 | IC50 | 2.1 | um | indirect | 20221018 |
| Papain | 10.1101/2021.02.13.431008 | IC50 | 10 | micro | indirect | 20221018 |
| Pazopanib | 10.1101/2021.03.19.435806 | IC50 | 29 | indirect | 20221018 | |
| Pectin | 10.1101/2021.10.27.466067 | EC50 | 0.9 | indirect | 20221018 | |
| Phenothiazine | 10.1101/2020.08.29.273441 | IC50 | 3 | indirect | 20221018 | |
| Phenothiazine | 10.1101/2020.05.05.079608 | IC50 | 10 | indirect | 20221018 | |
| Phosphate | 10.1016/j.mehy.2020.109783 | EC50 | 0.72 | um | indirect | 20221018 |
| Phosphate | 10.1093/cid/ciaa237 | EC50 | 0.72 | um | indirect | 20221018 |
| Phospholipids | 10.1101/2021.01.12.426042 | IC50 | 0.06 | indirect | 20221018 | |
| Pimozide | 10.1101/2020.05.23.112235 | IC50 | 100 | um | indirect | 20221018 |
| Plitidepsin | 10.1101/2020.04.23.055756 | IC50 | 25 | um | indirect | 20221018 |
| Proline | 10.1101/2021.02.17.431647 | IC50 | 1 | indirect | 20221018 | |
| Quercetin | 10.1101/2021.07.01.450756 | IC50 | 0.125 | um | indirect | 20221018 |
| Quercetin | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Remdesivir | 10.1101/2021.03.25.436935 | IC50 | 1 | indirect | 20221018 | |
| Remdesivir | 10.21203/rs.3.rs-36439/v1 | EC50 | 0.008 | um | indirect | 20221018 |
| Remdesivir | 10.1101/2020.06.26.174698 | IC50 | 1 | indirect | 20221018 | |
| Remdesivir | 10.1101/2021.01.08.425825 | IC50 | 0.1 | indirect | 20221018 | |
| Remdesivir | 10.1101/2020.12.29.424534 | EC50 | 769.1 | indirect | 20221018 | |
| Remdesivir | 10.1101/2021.09.30.462449 | IC50 | 1.8 | micro | indirect | 20221018 |
| Remdesivir | 10.1101/2020.12.01.407361 | IC50 | 180 | nm | indirect | 20221018 |
| Remdesivir | 10.1101/2020.11.19.389726 | IC50 | 1.28 | indirect | 20221018 | |
| Remdesivir | 10.1101/2020.10.28.359042 | EC50 | 0.08 | indirect | 20221018 | |
| Remdesivir | 10.1101/2020.09.16.299537 | EC50 | 10 | indirect | 20221018 | |
| Remdesivir | 10.1101/2021.04.02.438204 | IC50 | 1 | um | indirect | 20221018 |
| Remdesivir | 10.1101/2021.12.16.472155 | IC50 | 0.79 | um | indirect | 20221018 |
| Remdesivir | 10.1101/2022.02.09.479840 | EC50 | 0.31 | indirect | 20221018 | |
| Remdesivir | 10.1101/2020.04.23.055756 | IC50 | 25 | um | indirect | 20221018 |
| Remdesivir | 10.1101/2022.02.07.479493 | EC50 | 50 | indirect | 20221018 | |
| Remdesivir | 10.1101/2021.03.19.435806 | IC50 | 29 | indirect | 20221018 | |
| Remdesivir | 10.1101/2021.11.03.467186 | EC50 | 4.1 | indirect | 20221018 | |
| Resveratrol | 10.1101/2021.04.29.442010 | IC50 | 0.11 | um | indirect | 20221018 |
| Rhamnose | 10.1101/2021.10.27.466067 | EC50 | 0.9 | indirect | 20221018 | |
| Rhamnose | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Rhamnose | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Ribose | 10.1101/2021.11.03.467186 | EC50 | 4.1 | indirect | 20221018 | |
| Ritonavir | 10.30651/jqm.v4i2.4998 | EC50 | 1 | um | indirect | 20221018 |
| Ritonavir | 10.1101/2020.07.05.20146878 | EC50 | indicated insufficient lpv concentrations | indirect | 20221018 | |
| Ritonavir | 10.1101/2020.03.22.20034041 | IC50 | 0.29 | nm | indirect | 20221018 |
| Rutin | 10.21203/rs.3.rs-33294/v1 | IC50 | 19 | indirect | 20221018 | |
| Rutin | 10.1101/2021.07.01.450756 | IC50 | 0.125 | um | indirect | 20221018 |
| Salinomycin | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Serine | 10.1101/2021.05.06.442935 | EC50 | 430 | nm | indirect | 20221018 |
| Serine | 10.21203/rs.3.rs-34021/v1 | EC50 | 96 | indirect | 20221018 | |
| Serine | 10.21203/rs.3.rs-34021/v4 | EC50 | 96 | indirect | 20221018 | |
| Serine | 10.21203/rs.3.rs-34021/v5 | EC50 | 96 | indirect | 20221018 | |
| Serotonin | 10.1101/2020.06.14.150490 | EC50 | 387 | indirect | 20221018 | |
| Sofosbuvir | 10.1101/2020.06.22.165712 | EC50 | 1.32 | indirect | 20221018 | |
| Sulfate | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Sulfate | 10.1101/2020.05.10.087288 | IC50 | 38 | nm | indirect | 20221018 |
| Sulfate | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Sulfate | 10.30651/jqm.v4i2.4998 | EC50 | 1 | um | indirect | 20221018 |
| Sulfate | 10.1101/2020.08.20.260190 | EC50 | 0.09 | indirect | 20221018 | |
| Sulfate | 10.1101/2020.06.08.140236 | IC50 | 599 | indirect | 20221018 | |
| Sulfate | 10.1039/d0fo02017f | IC50 | 9.1 | ug | indirect | 20221018 |
| Sulfate | 10.1093/cid/ciaa237 | EC50 | 0.72 | um | indirect | 20221018 |
| Sunitinib | 10.1101/2021.03.19.435806 | IC50 | 29 | indirect | 20221018 | |
| Tenofovir | 10.1101/2020.06.22.165712 | EC50 | 1.32 | indirect | 20221018 | |
| Teriflunomide | 10.1101/2020.03.11.983056 | EC50 | 17 | nm | indirect | 20221018 |
| Thein | 10.1101/2020.11.29.401984 | EC50 | 0.147 | nm | indirect | 20221018 |
| Thimerosal | 10.1371/journal.pone.0240079 | IC50 | 0.2 | um | indirect | 20221018 |
| Threonine | 10.1101/2021.12.18.473330 | EC50 | 1 | um | indirect | 20221018 |
| Threonine | 10.1101/2021.12.18.473326 | IC50 | 4.8 | nm | indirect | 20221018 |
| Tocilizumab | 10.1101/2020.07.05.20146878 | EC50 | indicated insufficient lpv concentrations | indirect | 20221018 | |
| Trypsin | 10.1101/2020.06.23.167544 | IC50 | 0.27 | nm | indirect | 20221018 |
| Tryptophan | 10.1042/BCJ20220380 | IC50 | 2 | um | indirect | 20221018 |
| Tyrosine | 10.1101/2020.08.31.274639 | EC50 | 0.1 | micro | indirect | 20221018 |
| Tyrosine | 10.1101/2021.03.19.435806 | IC50 | 29 | indirect | 20221018 | |
| Valinomycin | 10.1016/j.bj.2020.05.003 | EC50 | 11 | nm | indirect | 20221018 |
| Velpatasvir | 10.1101/2020.06.22.165712 | EC50 | 1.32 | indirect | 20221018 | |
| Water | 10.1101/2020.12.29.424534 | EC50 | 769.1 | indirect | 20221018 | |
| Water | 10.1101/2021.09.08.459260 | IC50 | 0.3 | indirect | 20221018 | |
| Xylose | 10.1101/2021.01.14.426521 | IC50 | 0.48 | None | indirect | 20221010 |
| Xylose | 10.1101/2021.01.14.426521 | EC50 | 2.01 | indirect | 20221018 | |
| Yeast | 10.1101/2021.01.07.425806 | IC50 | 60 | indirect | 20221018 | |
| Yeast | 10.1101/2020.07.31.231746 | IC50 | 10 | indirect | 20221018 |
我们正在尽最大努力从最近的出版物中收集SARS-CoV-2体外实验结果。该数据集将不断更新。
最后更新日期：2020年11月10日
| Rank_ID | Drug Name | SARS-CoV-2 EC50/IC50(μM) | CC50(μM) | SI |
|---|---|---|---|---|
| 1 | Nafamostat | 0.0022 | >25 | 11363 |
| 2 | Amuvatinib | 0.02 | 0.06 | 3 |
| 3 | Apilimod | 0.023 | N/A | N/A |
| 4 | Apilimod | 0.023 | N/A | N/A |
| 5 | Carboxyamidotriazole | 0.09 | 0.11 | 1.22 |
| 6 | Ouabain | 0.097 | 50 | 515.5 |
| 7 | Pristimerin | 0.11 | 1.1 | 10.00 |
| 8 | Z-FA-FMK | 0.13 | N/A | N/A |
| 9 | VBY -825 | 0.14 | N/A | N/A |
| 10 | MLN-3897 | 0.14 | N/A | N/A |
| 11 | Digitoxin | 0.16 | >50 | 312.5 |
| 12 | Digoxin | 0.19 | >50 | 256.61 |
| 13 | AI-10-49 | 0.19 | 6.58 | 34.63 |
| 14 | Z LVG CHN2 | 0.19 | N/A | N/A |
| 15 | Tyrphostin | 0.2 | 1.36 | 6.8 |
| 16 | CAA-0225 | 0.2 | N/A | N/A |
| 17 | Polidocanol | 0.22 | 10.3 | 46.82 |
| 18 | MDL 28170 | 0.22 | N/A | N/A |
| 19 | Digitoxin | 0.23 | >50 | 214.1 |
| 20 | Salinomycin sodium | 0.24 | >50 | >211 |
| 21 | VLX600 | 0.24 | 0.06 | 0.25 |
| 22 | GSK2606414 | 0.25 | 70.35 | 281.4 |
| 23 | Cathepsin Inhibitor 1 | 0.25 | N/A | N/A |
| 24 | SL-11128 | 0.25 | N/A | N/A |
| 25 | Niclosamide | 0.28 | >50 | 176.65 |
| 26 | VBY -825 | 0.3 | N/A | N/A |
| 27 | Emetine | 0.46 | 56.46 | 122.74 |
| 28 | Salinomycin sodium | 0.5 | >50 | 100 |
| 29 | Calpeptin | 0.5 | N/A | N/A |
| 30 | ONO 5334 | 0.5 | N/A | N/A |
| 31 | Alvocidib | 0.59 | 0.06 | 0.1 |
| 32 | Cetylpyridinium chloride | 0.62 | 0.66 | 1.06 |
| 33 | Remdesivir | 0.62 | N/A | N/A |
| 34 | Pevonedistat | 0.63 | 222.44 | 353.08 |
| 35 | VPS34-IN1 | 0.63 | 10 | 15.87 |
| 36 | Ethaverine | 0.64 | 11.04 | 17.25 |
| 37 | Camostat | 0.64 | >20 | >31.25 |
| 38 | Berzosertib | 0.71 | 11.1 | 15.63 |
| 39 | Digoxin | 0.72 | >50 | 69.4 |
| 40 | Dapivirine | 0.73 | 5 | 6.85 |
| 41 | SDZ-62-434 | 0.75 | N/A | N/A |
| 42 | Remdesivir | 0.77 | >100 | >129.87 |
| 43 | AC1NDSS5 | 0.77 | 0.89 | 1.16 |
| 44 | SB-612111 | 0.77 | 3.67 | 4.77 |
| 45 | Thioguanosine | 0.78 | 0.63 | 0.81 |
| 46 | Niclosamide | 0.84 | >50 | 59.5 |
| 47 | LY2228820 | 0.87 | 56.2 | 64.6 |
| 48 | Hexachlorophene | 0.9 | 19.3 | 21.55 |
| 49 | AMG-2674 | 0.95 | N/A | N/A |
| 50 | YH-1238 | 0.95 | N/A | N/A |
| 51 | Papaverine | 1.1 | 4.49 | 4.08 |
| 52 | STF-62247 | 1.1 | 11.2 | 10.18 |
| 53 | Hanfangchin A | 1.1 | N/A | N/A |
| 54 | Elopiprazole | 1.1 | N/A | N/A |
| 55 | Astemizole | 1.1 | N/A | N/A |
| 56 | Chloroquine | 1.13 | >100 | >88.5 |
| 57 | Nelfinavir | 1.13 | 24.32 | 21.52 |
| 58 | SB-616234-A | 1.2 | N/A | N/A |
| 59 | KW 8232 | 1.2 | N/A | N/A |
| 60 | N-tert-Butylisoquine | 1.2 | N/A | N/A |
| 61 | Remdesivir | 1.3 | >50 | 38.5 |
| 62 | Z-Gly-Leu-Phe-chloromethyl ketone | 1.3 | N/A | N/A |
| 63 | ZK-93423 | 1.34 | 0.91 | 0.68 |
| 64 | VPS34 Inhibitor 1 | 1.4 | N/A | N/A |
| 65 | Almitrine | 1.42 | 102.2 | 71.97 |
| 66 | Hexachlorophene | 1.48 | >50 | 33.8 |
| 67 | Auranofin | 1.5 | low toxicity | N/A |
| 68 | Sorafenib | 1.55 | 1.17 | 0.75 |
| 69 | 8-(3-Chlorostyryl) caffeine | 1.6 | N/A | N/A |
| 70 | Posaconazole | 1.61 | 14.64 | 9.09 |
| 71 | Octenidine | 1.65 | 2.4 | 1.45 |
| 72 | Regorafenib | 1.67 | 0.97 | 0.58 |
| 73 | Thimerosal | 1.69 | 13.52 | 8 |
| 74 | Tioguanine | 1.71 | 2.21 | 1.29 |
| 75 | Hematoporphyrin | 1.85 | 160.08 | 86.53 |
| 76 | Chlormidazole | 1.89 | 0.88 | 0.47 |
| 77 | Ivermectin | 2 | low toxicity | N/A |
| 78 | Balicatib | 2 | N/A | N/A |
| 79 | Calpain | 2 | N/A | N/A |
| 80 | Methylene blue | 2.03 | 7.25 | 3.57 |
| 81 | Proscillaridin | 2.04 | >50 | >24.54 |
| 82 | Nitazoxanide | 2.12 | 35.53 | >16.76 |
| 83 | Azithromycine | 2.12 | >40 | >19 |
| 84 | Ketoconazole | 2.36 | 28.62 | 12.13 |
| 85 | alpha-L- Arabinopyrano se | 2.4 | N/A | N/A |
| 86 | Homoharringtonine | 2.55 | 59.75 | 23.43 |
| 87 | Ravuconazole | 2.76 | 12.75 | 4.62 |
| 88 | LDK378 | 2.86 | 6.84 | 2.39 |
| 89 | Tetrandrine | 3 | 14.92 | 4.97 |
| 90 | Alisporivir | 3.1 | >20 | >6.45 |
| 91 | ML414 | 3.2 | N/A | N/A |
| 92 | Isoosajin | 3.22 | 9.89 | 3.07 |
| 93 | Osimertinib mesylate | 3.26 | 13.23 | 4.05 |
| 94 | LGK-974 | 3.27 | 7.61 | 2.33 |
| 95 | Mibampator | 3.28 | 8.66 | 2.64 |
| 96 | Bazedoxifene | 3.44 | 14.97 | 4.35 |
| 97 | MCOPPB | 3.5 | N/A | N/A |
| 98 | GW 803430 | 3.5 | N/A | N/A |
| 99 | IT1t dihydrochloride | 3.5 | N/A | N/A |
| 100 | Oxyclozanide | 3.71 | >50 | >13.49 |
| 101 | Lusutrombopag | 3.78 | 14.61 | 3.87 |
| 102 | S-15176 difumarate salt | 3.8 | N/A | N/A |
| 103 | Osajin | 3.87 | 11.44 | 2.95 |
| 104 | Hydroxyprogesterone caproate | 3.87 | >50 | 12.9 |
| 105 | Dronedarone HCl | 3.92 | 8.75 | 2.23 |
| 106 | Avasimibe | 3.93 | 13.71 | 3.49 |
| 107 | Amodiaquin dihydrochloride | 4 | N/A | N/A |
| 108 | Chlorpromazine Hydrochloride | 4.03 | 11.88 | 2.94 |
| 109 | Tilorone | 4.09 | 19.67 | 4.81 |
| 110 | Hydroxychloroquine Sulfate | 4.17 | >40 | >10 |
| 111 | Ciclesonide | 4.33 | >50 | >11.56 |
| 112 | Cepharanthine | 4.47 | >50 | >11.18 |
| 113 | N- Methylspiperon e hydrochloride | 4.5 | N/A | N/A |
| 114 | Isopomiferin | 4.51 | 14.25 | 3.16 |
| 115 | Anidulafugin | 4.64 | >50 | >10.78 |
| 116 | Ebselen | 4.67 | low toxicity | N/A |
| 117 | Cyclosporine | 4.69 | >50 | 10.5 |
| 118 | Amodiaquin Dihydrochloride Dihydrate | 4.94 | 34.42 | 6.97 |
| 119 | Penfluridol | 5.01 | 8.77 | 1.75 |
| 120 | Opipramol dihydrochloride | 5.05 | >40 | >7.9 |
| 121 | Quinacrine hydrochloride monohydrate | 5.11 | >40 | >7.8 |
| 122 | CVL218 | 5.12 | 91.05 | 17.78 |
| 123 | Amodiaquine hydrochloride | 5.15 | >50 | >9.71 |
| 124 | Imatinib Mesylate | 5.32 | >30.86 | >5.80 |
| 125 | Fluspirilene | 5.32 | 30.33 | 5.71 |
| 126 | Clomiphene Citrate | 5.36 | 15.01 | 2.8 |
| 127 | Alprostadil | 5.39 | >40 | >7.4 |
| 128 | Pexidartinib | 5.43 | 41.53 | 7.65 |
| 129 | JTV519 Hemifumarate | 5.5 | N/A | N/A |
| 130 | Amodiaquin Hydrochloride | 5.64 | >38.63 | >6.84 |
| 131 | Lonafarnib | 5.68 | 10.71 | 1.89 |
| 132 | Avatrombopag | 5.71 | 20.86 | 3.65 |
| 133 | Cyclosporine | 5.82 | >50 | >8.59 |
| 134 | Apixaban | 5.91 | 18.07 | 3.06 |
| 135 | Proscillaridin | 5.95 | >50 | 8.4 |
| 136 | IPAG | 5.96 | 11.48 | 1.93 |
| 137 | JTE-013 | 5.97 | 16.45 | 2.76 |
| 138 | Drotaverine | 6.07 | 9 | 1.48 |
| 139 | Hydroxyprogesterone caproate | 6.3 | >50 | 7.93 |
| 140 | Perhexiline maleate | 6.38 | 8.67 | 1.36 |
| 141 | Triparanol | 6.41 | 21.21 | 3.31 |
| 142 | Ivacaftor | 6.57 | 12.47 | 1.9 |
| 143 | Droloxifene((E)-3-Hydroxy tamoxifen) | 6.6 | 15.82 | 2.4 |
| 144 | Abemaciclib | 6.62 | >50 | >7.56 |
| 145 | Thioridazine hydrochloride | 6.69 | 15.96 | 2.39 |
| 146 | Gilteritinib | 6.76 | 37.16 | 5.5 |
| 147 | Oxyclozanide | 6.78 | >50 | 7.37 |
| 148 | Ebastine | 6.92 | 15.42 | 2.23 |
| 149 | Triparanol | 7.05 | 14.73 | 2.09 |
| 150 | IKK-2 Inhibitor VIII | 7.1 | N/A | N/A |
| 151 | Mequitazine | 7.28 | 27.34 | 3.76 |
| 152 | Clomipramine Hydrochloride | 7.59 | >29.68 | >3.91 |
| 153 | Berbamine hydrochloride | 7.87 | >50 | >6.35 |
| 154 | Clemastine fumarate | 7.9 | N/A | N/A |
| 155 | GMC 2-29 | 7.9 | N/A | N/A |
| 156 | Thiethylperazine Maleate | 8.02 | 18.37 | 2.29 |
| 157 | Mefloquine Hydrochloride | 8.06 | 18.53 | 2.3 |
| 158 | Eltrombopag | 8.27 | >50 | >6.05 |
| 159 | Eltrombopag | 8.38 | 48.85 | 5.83 |
| 160 | Saquinavir | 8.83 | 44.43 | 5.03 |
| 161 | NSC 33994 | 8.9 | N/A | N/A |
| 162 | Rescimetol | 8.9 | N/A | N/A |
| 163 | Fluphenazine Dihydrochloride | 8.98 | 20.02 | 2.23 |
| 164 | Tamoxifen Citrate | 8.98 | 37.96 | 4.23 |
| 165 | Lopinavir | 9.12 | >50 | >5.18 |
| 166 | Loperamide | 9.27 | 29.26 | 3.16 |
| 167 | Atazanavir | 9.36 | >81 | >8.65 |
| 168 | Lu AE58054 hydrochloride Chlorprothixen e | 10 | N/A | N/A |
| 169 | Methdilazine hydrochloride | 10 | N/A | N/A |
| 170 | Methotrimepra zine maleate | 10 | N/A | N/A |
| 171 | Piperacetazine | 10 | N/A | N/A |
| 172 | Difeterol | 10 | N/A | N/A |
| 173 | (R)-(-)-L Y 426965 dihydrochloride Loperamide hydrochloride | 10 | N/A | N/A |
| 174 | Naltrindole isothiocyanate hydrochloride | 10 | N/A | N/A |
| 175 | AM1241 | 10 | N/A | N/A |
| 176 | CpdD hydrochloride | 10 | N/A | N/A |
| 177 | SB 271046 hydrochloride | 10 | N/A | N/A |
| 178 | GMC 2-113 | 10 | N/A | N/A |
| 179 | Imatinib | 10 | N/A | N/A |
| 180 | Duloxetine hydrochloride | 10 | N/A | N/A |
| 181 | Trifluomeprazi ne 2- butenedioate Asteriscunolide D Genz-123346 (free base) | 10 | N/A | N/A |
| 182 | Maprotiline hydrochloride | 10 | N/A | N/A |
| 183 | Deserpidine | 10 | N/A | N/A |
| 184 | Amiodarone hydrochloride | 10 | N/A | N/A |
| 185 | Melitracen hydrochloride | 10 | N/A | N/A |
| 186 | (+/-) - Fluoxetine | 10 | N/A | N/A |
| 187 | Flunarizine | 10 | N/A | N/A |
| 188 | Proglumetacin DMP 777 Dexanabinol | 10 | N/A | N/A |
| 189 | Promethazine Hydrochloride | 10.44 | >42.59 | >4.08 |
| 190 | Ciclesonide | 10.64 | >50 | 4.7 |
| 191 | LDE225 | 10.67 | 2.26 | 0.21 |
| 192 | Arbidol | 10.7 | >40 | >3.7 |
| 193 | Toremifene Citrate | 11.3 | 20.51 | 1.81 |
| 194 | Ivacaftor | 11.55 | 30.38 | 2.63 |
| 195 | N-(2-hydroxypropyl)-3-trimethylammonium 46chitosan chloride | 12.5 | 158 | 12.6 |
| 196 | Loperamide hydrochloride | 12.53 | 47.4 | 3.78 |
| 197 | Bazedoxifene | 12.63 | 27.84 | 2.2 |
| 198 | DCPIB | 12.78 | 24.55 | 1.92 |
| 199 | Tipranavir | 13.34 | 76.8 | 5.76 |
| 200 | Dihydrogambogic acid | 13.37 | 9.85 | 0.74 |
| 201 | Tetrandrine | 13.5 | 22.3 | 1.71 |
| 202 | AMG-9810 | 14.97 | 14.22 | 0.95 |
| 203 | Loratadine | 15.13 | 28.33 | 1.87 |
| 204 | Brexpiprazole | 16.04 | 50.57 | 3.15 |
| 205 | Erconazole Vetranal | 16.14 | 41.46 | 2.57 |
| 206 | N3 | 16.77 | >133 | >7.93 |
| 207 | CC-223 | 16.78 | 9.49 | 0.57 |
| 208 | CBIPES | 17.05 | 13.4 | 0.79 |
| 209 | Omeprazole | 17.06 | >40 | >2.35 |
| 210 | Anidulafungin | 17.23 | >50 | 2.9 |
| 211 | Lidoflazine | 17.39 | 31.91 | 1.83 |
| 212 | Benztropine Mesylate | 17.79 | >50 | >2.81 |
| 213 | Loteprednol etabonate | 17.92 | 49.03 | 2.74 |
| 214 | Vatalanib | 18.27 | 64.18 | 3.51 |
| 215 | Adoprazine | 18.59 | 75.9 | 4.08 |
| 216 | PH-797804 | 18.85 | 19.97 | 1.06 |
| 217 | Cloconazole | 18.92 | 33 | 1.74 |
| 218 | BP-897 | 18.95 | 30.03 | 1.58 |
| 219 | Harringtonine | 19 | 0.07 | 0 |
| 220 | Flunarizine | 19.05 | 136.76 | 7.18 |
| 221 | PF-670462 | 19.23 | 8.24 | 0.43 |
| 222 | Oxprenolol hydrochloride | 20.22 | >40 | >2 |
| 223 | Etifoxine | 20.64 | 43.53 | 2.11 |
| 224 | Oxiconazole | 20.82 | 26.36 | 1.27 |
| 225 | Lopinavir | 21.7 | >50 | 2.3 |
| 226 | Dolutegravir | 22.04 | >40 | >1.8 |
| 227 | Nafamostat | 22.5 | >100 | >4.44 |
| 228 | Clemizole hydrochloride | 23.94 | >40 | >1.7 |
| 229 | Phenazopyridine | 28 | >50 | >1.79 |
| 230 | Cepharanthine | 30 | >50 | 1.67 |
| 231 | Amprenavir | 31.32 | >81 | >2.59 |
| 232 | Sulfadoxine | 35.37 | >40 | >1.13 |
| 233 | Abemaciclib | 43.7 | >50 | 1.1 |
| 234 | Darunavir | 46.41 | >81 | >1.75 |
| 235 | Chloroquine Phosphate | 46.8 | >50 | >1.07 |
| 236 | Indinavir | 59.14 | >81 | >1.37 |
| 237 | Favipiravir | 61.88 | >400 | >6.46 |
| 238 | Chloroquine | 69.2 | >250 | 3.6 |
| 239 | Penciclovir | 95.96 | >400 | >4.17 |
| 240 | Remdesivir | 100 | N/A | N/A |
| 241 | Ribavirin | 109.5 | >400 | >3.65 |
| 242 | Lanatoside C | >50 | >50 | 1 |
| 243 | Quinacrine hydrochloride | >50 | 14.71 | <0.29 |
| 244 | Berbamine hydrochloride | >50 | >50 | 1 |
| 245 | Gilteritinib | >50 | >50 | 1 |
| 246 | Amodiaquine dihydrochloride | >50 | >50 | 1 |
| 247 | Mefloquine | >50 | >50 | 1 |
| 248 | Ouabain | <0.1 | >50 | 633 |
| 249 | NSC319726 | <0.02 | <0.02 | 1 |
- 各种研究中使用的细胞系和试验条件可能不同。
- 当前表格按效价排序。
参考文献：
1.Remdesivir和氯喹在体外能有效抑制最近出现的新型冠状病毒(2019-nCoV)。Cell research,2020,30(3):269-271.
2.一个数据驱动的药物重新定位框架发现了一种潜在的靶向COVID-19的治疗药物。bioRxiv,2020.
3.FDA批准的具有广泛抗冠状病毒活性的药物在体外抑制SARS-CoV-2。bioRxiv,2020.
4.HTCC作为SARS-CoV-2和MERS-CoV的高效聚合物抑制剂，bioRxiv,2020.
5.从FDA批准的药物中鉴定出抗SARS-CoV-2的抗病毒候选药物，bioRxiv，2020.
6.FDA批准的药物伊维菌素在体外抑制SARS-CoV-2的复制
9.Remdesivir、洛匹那韦、依米丁和高三尖杉酯碱在体外抑制SARS-CoV-2复制
10.FDA批准的金药物Auranofin抑制新型冠状病毒(SARS-COV-2)复制，减轻人体细胞炎症
11.使用大规模药物再利用集合鉴定SARS-CoV-2在人(Caco-2)细胞中的体外细胞毒性抑制剂
12.体外筛选FDA批准的化学库揭示SARS-CoV-2复制的潜在抑制剂
13.FDA批准的抗SARS-CoV-2药物在人肺细胞中抗病毒疗效的比较分析：Nafamostat是最强效的抗病毒候选药物
14、抑制SARS-CoV-2细胞病变效应化合物的药物复性筛选
15.SARS-CoV-2抗病毒药物的大规模药物重新定位调查