Initial Data Analysis Results

I. Based on previous experimental data

1. Top target (RdRp) specific antiviral candidates

Drug name DrugBank ID Clinical Information Mechanism of action Experimental activity Method parameter PX mean unit
Remdesivir DB14761 1. Phase III for Ebola
2. Phase III for nCoV
RNA-Directed RNA Polymerase Inhibitor Ebola virus disease remission/reduction, IN VITRO IC-50 8 0.00000001 M
Lumicitabine DB14808 Phase II completed for Respiratory Syncytial Virus RNA-Directed RNA Polymerase (Respiratory Syncytial Virus) Inhibitors Infection, respiratory syncytial virus (RSV) remission/reduction, IN VITRO Viral replication assay IC-50 6.58 0.00000026 M
Sofosbuvir DB08934 Phase 4 completed for HCV
Marketed for HCV
RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors Infection, dengue virus remission/reduction, IN VITRO Plaque assay IC-90 6.40 0.0000004 M
Adafosbuvir DB14906 Phase II completed for HCV RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors Infection, dengue virus remission/reduction, IN VITRO Plaque assay IC-50 5.96 0.0000011 M
Balapiravir hydrochloride DB12283 1. Phase I completed for Dengue Fever
2. Phase II completed for HCV
RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors Infection, dengue virus remission/reduction, IN VITRO Viral replication assay IC-50 5.72 0.0000019 M
Galidesivir DB11676 1. Phase I competed for Ebola
2. Phase I started for Marburg virus
3. Phase 1 started for yellow fever
RNA Polymerase Inhibitors Infection, Zika virus remission/reduction, IN VITRO Fluorescent assay IC-50 5.53 0.00000296 M
Beclabuvir DB12225 Phase III completed for HCV, Phase IV withdrawn for HCV RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors Infection, herpes simplex virus remission/reduction, IN VITRO Viral replication assay (multiple cycle) IC-50 5.40 0.000004 M
Favipiravir DB12466 1. Phase III completed for Influenza
2. Phase II completed for Ebola
RNA-Directed RNA Polymerase (Influenza A Virus H1N1) Inhibitors;RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors Infection, rabies virus remission/reduction, IN VITRO Fluorescent assay MIC 5.40 0.000004 M

2. Top antiviral candidates selected from viral replication assay

Drug name DrugBank ID Clinical Information Mechanism of action Experimental activity Method parameter PX mean unit
Deferiprone DB08826 1. Phase 4 completed for acute iron intoxication
2. Phase 4 completed for Hepatic impairment
3. Phase 4 completed for impaired kidney function
4. Phase 4 completed for Beta-Thalassemia
5. Phase 4 completed for hemosiderosis
6. Phase 4 completed for Prolonged QT Interval
7. Phase III completed for Parkinson's disease;
Marketed for iron toxicity
Chelating Agents;Cytochrome P450 CYP4F2 Inhibitors Infection, BK polyomavirus remission/reduction, IN VITRO Viral replication assay IC-50 8.46 3.50E-09 M
Raltegravir potassium DB06817 Phase 4 completed for HIV
Marketed for Anti-Retroviral HIV
HIV Integrase Inhibitors Infection, xenotropic murine leukemia virus-related virus remission/reduction, IN VITRO Viral replication assay IC-50 8.30 0.000000005 M
Verdinexor DB12207 Phase 1 completed for basic science on health volunteers Exportin-1 (CRM1, XPO1) Receptor Antagonists;Signal Transduction Modulators Infection, JC polyomavirus remission/reduction, IN VITRO Viral replication assay IC-50 8.12 7.50E-09 M
Brincidofovir DB12151 Phase 3 completed for adenovirus infections DNA Polymerase Inhibitors Infection, JC polyomavirus remission/reduction, IN VITRO Viral replication assay IC-50 7.7 0.00000002 M
Remdesivir DB14761 1. Phase III for Ebola
2. Phase III for nCoV
Nucleobindin-1 (NUCB1) Inhibitors Middle East respiratory syndrome coronavirus (MERS-CoV) remission/reduction, IN VITRO Viral replication assay IC-50 7.60 0.000000025 M
Verdinexor DB12207 Phase I completed for basic science experiments on healthy volunteers Exportin-1 (CRM1, XPO1) Receptor Antagonists;Signal Transduction Modulators Infection, adenovirus remission/reduction, IN VITRO Viral replication assay IC-50 7.52 0.00000003 M
Cidofovir DB00369 Phase 4 completed for cytomegalovirus
Marketed for CMV in AIDS patients
DNA Polymerase Inhibitors Infection, cytomegalovirus remission/reduction, IN VITRO Viral replication assay IC-99 7.22 0.00000006 M
Alvocidib hydrochloride DB03496 1. Phase II completed for sarcomas
2. Phase II completed for renal cancers;
3. Phase II completed for melanoma
4. Phase II completed for other cancers including: myeloma, carcinoma, esophageal, endometrial, leukaemia, etc.
Cyclin-Dependent Kinase 1 (CDK1) Inhibitors;Signal Transduction Modulators;Cyclin-Dependent Kinase 6 (CDK6) Inhibitors;CDK9/Cyclin T1 Inhibitors;Baculoviral IAP Repeat-Containing Protein 5 (BIRC5; Survivin) Inhibitors;Apoptosis Inducers;Cyclin-Dependent Kinase 7 (CDK7) Inhibitors;Cyclin-Dependent Kinase 2 (CDK2) Inhibitors;Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Inhibitors;Cyclin-Dependent Kinase 4 (CDK4) Inhibitors;X-Chromosome-Linked Inhibitor of Apoptosis Protein (XIAP) Inhibitors;Apoptosis Regulator Bcl-2 Inhibitors Infection, herpes virus remission/reduction, IN VITRO Viral replication assay IC-50 7.00 1.00E-07 M
Ganciclovir DB01004 1. Phase 4 active for viral pneumonia
2. Phase 4 completed for DNA virus infections
3. Phase 4 completed for CMV
4. Phase 4 completed for viral sepsis
DNA Polymerase Inhibitors Infection, herpes simplex virus remission/reduction, IN VITRO Viral replication assay IC-50 7 0.0000001 M

3. Top antiviral candidates selected from different assays

Drug_name DrugBank ID Clinical Information Mechanism of action Experimental activity Method parameter PX mean unit
Presatovir DB12165 Phase II completed for Respiratory Syncytial Virus Respiratory Syncytial Virus (RSV) Fusion Inhibitors;Viral Fusion Inhibitors Infection, respiratory syncytial virus (RSV) remission/reduction, IN VITRO Cytopathicity assay IC-50 11.74 1.80E-12 M
Brincidofovir DB12151 Phase III completed for AdV, BKV, CMV, EBV, and HHV6 DNA Polymerase Inhibitors Infection, cytomegalovirus remission/reduction, IN VITRO DNA assay IC-50 11.70 2.00E-12 M
Sorivudine DB11998 Phase III completed for Chickenpox, HIV DNA Polymerase Inhibitors Infection, varicella zoster virus remission/reduction, IN VITRO Plaque assay IC-50 10.62 2.40E-11 M
Peramivir DB06614 Phase 4 completed for influenza
Marketed for influenza
Neuraminidase (Sialidase) (Influenza Virus) Inhibitors Neuraminidase (nonspecified subtype) (Influenza A virus) inhibition, IN VITRO 4-Methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid as substrate Ki 10.85 1.40E-11 M
Peramivir DB06614 Phase 4 completed for influenza
Marketed for influenza
Neuraminidase (Sialidase) (Influenza Virus) Inhibitors Neuraminidase (nonspecified subtype) (Influenza A virus) inhibition, IN VITRO 4-Methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid as substrate IC-50 10.30 5.00E-11 M
Zanamivir DB00558 Phase 4 completed for influenza
Marketed for influenza
Neuraminidase (Sialidase) (Influenza Virus) Inhibitors Neuraminidase (nonspecified subtype) (Influenza A virus) inhibition, IN VITRO Chemiluminescent assay IC-50 10.52 3.00E-11 M
Sirolimus DB00877 1. Phase 4 completed for renal diseases, renal failure
2. Phase 4 completed for kidney and heart transplatation
Marketed for kidney transplantation
CCR5 Expression Inhibitors;Cytochrome P450 CYP2D6 Inhibitors;Signal Transduction Modulators;Cytochrome P450 CYP2C9 Inhibitors;P-Glycoprotein (MDR-1; ABCB1) Inhibitors;Proteasome Inhibitors;Mammalian Target of Rapamycin (mTOR; FRAP1) Inhibitors;Drugs Targeting B-Lymphocyte Antigen CD19 Infection, cytomegalovirus remission/reduction, IN VITRO Chemiluminescent assay IC-50 10.40 4.00E-11 M
Laninamivir DB12791 Phase I completed for influenza Neuraminidase (Sialidase) (Influenza Virus) Inhibitors Neuraminidase (nonspecified subtype) (Influenza A virus) inhibition, IN VITRO Fluorescent assay IC-50 9.96 1.10E-10 M
Ribavirin DB00811 1. nCoV clinical trial
2. Phase 4 completed for HCV
3. Phase 3 completed for HBV
Marketed for RSV, HCV,
Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors;Equilibrative Nucleoside Transporter ENT1 Inhibitors Infection, respiratory syncytial virus (RSV) remission/reduction, IN VITRO ELISA assay IC-50 9.90 1.26E-10 M


II. Based on sematic literature mining

1. Pharmacologic Substance

Source Concept Source Concept Categories Relationship Type Target Concept Target Concept Categories Score Count of Evidence Evidence contains clinical studies? Count of Evidence per rel type
protease inhibitors Pharmacologic Substance DOWNREGULATE sars coronavirus Virus 7.9481972 3 no DOWNREGULATE: 3
proteasome inhibitor Pharmacologic Substance DOWNREGULATE sars coronavirus Virus 6.504773223 2 no DOWNREGULATE: 2
hiv protease inhibitors Pharmacologic Substance DOWNREGULATE sars coronavirus Virus 2.051117514 1 no DOWNREGULATE: 1
cardiotonic agents Pharmacologic Substance DOWNREGULATE genus: coronavirus Virus 1.367411676 1 no DOWNREGULATE: 1
chinese herbs Pharmacologic Substance DOWNREGULATE sars coronavirus Virus 1.367411676 1 no DOWNREGULATE: 1
anthelmintics Pharmacologic Substance DOWNREGULATE sars coronavirus Virus 1.367411676 1 no DOWNREGULATE: 1
antiviral agents Pharmacologic Substance DOWNREGULATE human coronavirus Virus 1.093929341 1 no DOWNREGULATE: 1
kinase inhibitor Pharmacologic Substance DOWNREGULATE sars coronavirus Virus 1.093929341 1 no DOWNREGULATE: 1

2. Organic chemicals

Source Concept Source Concept Categories Relationship Type Target Concept Target Concept Categories Score Count of Evidence Evidence contains clinical studies? Count of Evidence per rel type
fk-506 Organic Chemical DOWNREGULATE human coronavirus nl63 Virus 10.64417436 2 no DOWNREGULATE: 2
glycyrrhizic acid Organic Chemical DOWNREGULATE sars coronavirus Virus 8.142055669 3 no DOWNREGULATE: 3
chloroquine Organic Chemical DOWNREGULATE genus: coronavirus Virus 7.560480264 3 no DOWNREGULATE: 2, UNIDIRECTIONAL: 1
beta-thujaplicin Organic Chemical DOWNREGULATE genus: coronavirus Virus 7.096116243 2 no DOWNREGULATE: 2
lopinavir Organic Chemical DOWNREGULATE sars coronavirus Virus 5.913430203 2 no DOWNREGULATE: 2
u 18666a Organic Chemical DOWNREGULATE coronavirus, feline Virus 5.322087182 2 no DOWNREGULATE: 2
5-(n,n-hexamethylene)amiloride Organic Chemical DOWNREGULATE genus: coronavirus Virus 5.322087182 2 no DOWNREGULATE: 2
niclosamide Organic Chemical DOWNREGULATE sars coronavirus Virus 5.322087182 2 no DOWNREGULATE: 2
fumaric acid Organic Chemical DOWNREGULATE genus: coronavirus Virus 4.730744162 2 no DOWNREGULATE: 2
tapi-2 Organic Chemical DOWNREGULATE sars coronavirus Virus 4.730744162 2 no DOWNREGULATE: 2

3. Amino acids/peptides/proteins

Source Concept Source Concept Categories Relationship Type Target Concept Target Concept Categories Score Count of Evidence Evidence contains clinical studies? Count of Evidence per rel type
human leukocyte interferon Amino Acid, Peptide, or Protein DOWNREGULATE sars coronavirus Virus 11.88168037 17 no DOWNREGULATE: 11, UNIDIRECTIONAL: 4, UPREGULATE: 1, NEG_UNIDIRECTIONAL: 1
cyclosporine Amino Acid, Peptide, or Protein DOWNREGULATE sars coronavirus Virus 9.45060033 3 no DOWNREGULATE: 3
recombinant interferon alfa Amino Acid, Peptide, or Protein DOWNREGULATE sars coronavirus Virus 9.067622441 5 no DOWNREGULATE: 4, UNIDIRECTIONAL: 1
cytokine Amino Acid, Peptide, or Protein DOWNREGULATE sars coronavirus Virus 5.9611479 3 no DOWNREGULATE: 2, UNIDIRECTIONAL: 1
glycosyltransferase Amino Acid, Peptide, or Protein DOWNREGULATE sars coronavirus Virus 5.913430203 2 no DOWNREGULATE: 2
methyltransferase Amino Acid, Peptide, or Protein DOWNREGULATE sars coronavirus Virus 5.913430203 2 no DOWNREGULATE: 2
monoclonal antibodies Amino Acid, Peptide, or Protein DOWNREGULATE porcine respiratory coronavirus Virus 4.730744162 2 no DOWNREGULATE: 2
spike protein antibody Amino Acid, Peptide, or Protein DOWNREGULATE bovine coronavirus Virus 4.730744162 2 no DOWNREGULATE: 2

Data Download with Explanation and Preview

We are releasing the following datasets from our big data platform. We are making our best efforts to mine all experimental data of previous coronavirus related studies. If you have other specific data need or have datasets to contribute, please contact us @here. We will update our datasets periodically to provide more information to help your research combat the disease.

Compound Libraries for drug repositioning.

  • Dataset:
    • Please visit Drugbank to download the most recent data

Previous drug discovery effort for SARS/MERS

Annotated preclinical studies

  • A collection of 1690 in vitro and in vivo records for 245 molecules

  • Full dataset

A few selected records

drug_name tested_activity MOA_summary condition method material parameter operator mean value unit
PF-835231 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) IC-50 4.00E-09 M
Remdesivir Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Nucleobindin-1 (NUCB1) Inhibitors Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Calu3 human lung carcinoma cells (HER2 [ERBB2]-overexpressing) IC-50 1.00E-08 M
ARN-398 Ceramidase (nonspecified) inhibition, IN VITRO Acid Ceramidase (ACDase; ASAH1) Inhibitors Ceramidase (nonspecified) Rat enzyme IC-50 1.20E-08 M
SR9EK1 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-90 1.25E-08 M
Lycorine Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Dye assay Vero African green monkey kidney cells IC-50 1.57E-08 M
SR9EK1 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-99 1.76E-08 M
Noscapine Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Tubulin Polymerization Inhibitors;Apoptosis Inducers;Antimitotic Drugs Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-90 2.20E-08 g/l
Carmofur Ceramidase (nonspecified) inhibition, IN VITRO Thymidylate Synthase Inhibitors;Pyrimidine Antagonists Ceramidase (nonspecified) Rat enzyme IC-50 2.90E-08 M
JMF-1507 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) Ki 3.00E-08 M
Pristimerine Inflammatory disorders remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Inflammatory disorders ELISA assay RAW264.7 mouse macrophages MIC <= 3.13E-08 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Cell counting assay MiaPaCa2 human pancreas adenocarcinoma cells CC-50 4.80E-08 M
Pyrazofurin Nephrotoxicity induction, IN VITRO Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors Nephrotoxicity Cell viability assay Vero African green monkey kidney cells CC-50 5.20E-08 g/l
TG-0205221 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Coronavirus (SARS-associated) Ki 5.30E-08 M
JMF-1507 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) IC-50 6.00E-08 M
Pristimerine IL-2 Receptor Complex antagonism, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs IL-2 Receptor Complex Thymidine incorporation assay T-Lymphocytes (spleen), mouse MIC <= 6.25E-08 M
Pristimerine Inflammatory disorders remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Inflammatory disorders Nitrite assay RAW264.7 mouse macrophages MIC 6.25E-08 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Cell counting assay MiaPaCa2 human pancreas adenocarcinoma cells CC-50 6.39E-08 M
Remdesivir Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Nucleobindin-1 (NUCB1) Inhibitors Severe acute respiratory syndrome (SARS-CoV) Epithelial cells (airway), human IC-50 6.90E-08 M
Remdesivir Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Nucleobindin-1 (NUCB1) Inhibitors Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Epithelial cells (airway), human IC-50 6.90E-08 M
Pristimerine Cancer, pancreas remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas Cell counting assay CFPAC1 human pancreas cancer cells CC-50 7.70E-08 M
Niclosamide Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Cytochrome P450 CYP1A2 Inhibitors;Quorum Sensing (Pseudomonas aeruginosa) Inhibitors;Neuropeptide Y4 (NPY Y4) Receptor Positive Allosteric Modulators;Autophagy Inducers;Wnt Signaling Inhibitors Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-50 < 1.00E-07 M
Tingenone Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Cytotoxicity Dye assay (alamar blue) MRC5 human embryonic lung fibroblasts CC-50 1.00E-07 M
Isobavachalcone Tumor Necrosis Factor (TNF-alpha) inhibition, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Tumor Necrosis Factor (TNF-alpha) Chemiluminescent assay BV2 murine microglia cells MIC <= 1.00E-07 M
Tingenone Cancer, mouth (squamous cell) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Cancer, mouth (squamous cell) Dye assay (alamar blue) HSC3 human oral squamous cell carcinoma cells CC-50 1.00E-07 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Dye assay (MTT) @ 72 h HCT116 human colon carcinoma cells MIC <= 1.00E-07 M
Pristimerine Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon (adenocarcinoma) Dye assay (MTT) @ 72 h SW620 human colon adenocarcinoma cells MIC <= 1.00E-07 M
6',6'-Difluoroaristeromycin Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO S-Adenosyl-L-Homocysteine Hydrolase Inhibitors Severe acute respiratory syndrome (SARS-CoV) Plaque assay VeroE6 African green monkey kidney cells MIC <= 1.00E-07 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Cell counting assay BxPC3 human pancreas adenocarcinoma cells CC-50 1.03E-07 M
SR9EK2 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-90 1.08E-07 M
Azithromycin Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Nonsense Mutation Suppressors;50S Ribosomal Protein Inhibitors Severe acute respiratory syndrome (SARS-CoV) Luciferine/luciferase assay HEK293T human embryonic kidney cells transfected with luciferase IC-50 1.10E-07 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Cell counting assay Pancreatic ductal epithelial cells, human CC-50 1.11E-07 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Cell counting assay Pancreatic ductal epithelial cells, human CC-50 1.11E-07 M
Pristimerine NF-kappaB (NFkB) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs NF-kappaB (NFkB) Gene reporter assay OMM1 human uveal melanoma cells MIC <= 1.25E-07 M
Pristimerine Inflammatory disorders remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Inflammatory disorders ELISA assay RAW264.7 mouse macrophages MIC 1.25E-07 M
Isobavachalcone Dihydroorotate Dehydrogenase (quinone), mitochondrial (DHODH) inhibition, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Dihydroorotate Dehydrogenase (quinone), mitochondrial (DHODH) 2,6-dichlorophenolindophenol reduction assay Recombinant human enzyme IC-50 1.30E-07 M
TG-0205221 Coronavirus acute respiratory syndrome remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors Coronavirus acute respiratory syndrome Plaque assay MRC5 human embryonic lung fibroblasts IC-50 1.40E-07 M
SR9EK2 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-99 1.49E-07 M
JMF-1521 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-50 1.80E-07 M
SR9EK1 Nephrotoxicity induction, IN VITRO Nephrotoxicity Dye assay Vero African green monkey kidney cells CC-50 1.91E-07 M
Remdesivir Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Nucleobindin-1 (NUCB1) Inhibitors Severe acute respiratory syndrome (SARS-CoV) IC-50 2.00E-07 M
Pristimerine Leukemia, acute promyelocytic (M3) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Leukemia, acute promyelocytic (M3) Dye assay (MTT) HL60 human acute promyelocytic leukemia cells CC-50 2.00E-07 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Matrigel-coated plate assay PC3 human prostate adenocarcinoma cells MIC <= 2.00E-07 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Spheres formation assay PC3 human prostate adenocarcinoma cells MIC <= 2.00E-07 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Colony formation assay PC3 human prostate adenocarcinoma cells MIC <= 2.00E-07 M
Pristimerine Monoglyceride Lipase inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Monoglyceride Lipase 2-Oleoylglycerol as substrate Recombinant human enzyme IC-50 2.04E-07 M
N-3 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO 3C-Like Protease (NL63 Coronavirus) (HCoV-NL63) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) MCA-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-lys(Dnp)-lys-NH2 as substrate Coronavirus Ki 2.30E-07 M
Pristimerine NF-kappaB (NFkB) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs NF-kappaB (NFkB) Gene reporter assay Mel270 human uveal melanoma cells MIC 2.50E-07 M
Pristimerine NF-kappaB (NFkB) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs NF-kappaB (NFkB) Gene reporter assay OMM2.3 human uveal melanoma cells MIC 2.50E-07 M
Pristimerine MMP-9 (Gelatinase B) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs MMP-9 (Gelatinase B) 92.1 human uveal melanoma cells MIC <= 2.50E-07 M
Pristimerine Inflammatory disorders remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Inflammatory disorders ELISA assay RAW264.7 mouse macrophages MIC 2.50E-07 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Wound closure assay 92.1 human uveal melanoma cells MIC <= 2.50E-07 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Transwell chamber assay 92.1 human uveal melanoma cells MIC <= 2.50E-07 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Transwell chamber assay OMM1 human uveal melanoma cells MIC <= 2.50E-07 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Transwell chamber assay 92.1 human uveal melanoma cells MIC <= 2.50E-07 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Transwell chamber assay OMM1 human uveal melanoma cells MIC <= 2.50E-07 M
N-3 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO 3C-Like Protease (NL63 Coronavirus) (HCoV-NL63) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) MCA-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-lys(Dnp)-lys-NH2 as substrate Coronavirus Ki 2.60E-07 M
Betulinic acid GABA(A) BZ Site Receptor affinity, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors GABA(A) BZ Site Receptor Displacement of [3H]-flunitrazepam Brain, rat Ki 2.60E-07 M
Pristimerine Tumor Necrosis Factor Ligand Superfamily Member 11 (TNFSF11, RANKL) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Tumor Necrosis Factor Ligand Superfamily Member 11 (TNFSF11, RANKL) RNA assay Fibroblasts (synovial), rat (arthritic) MIC 3.00E-07 M
BTB-06256 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) IC-50 3.00E-07 M
GRL-0667 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 3.20E-07 M
Pristimerine Cancer, cervix, (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, cervix, (adenocarcinoma) Dye assay (MTT) HeLa human cervix adenocarcinoma cells IC-50 3.20E-07 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) ATP assay MDAMB231 human breast adenocarcinoma cells CC-50 3.80E-07 M
Sinefungin Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Coactivator Associated Arginine Methyltransferase 1 (CARM1; PRMT4) Inhibitors;Histone-Lysine N-Methyltransferase SETD7 (SET7/9) Inhibitors;Protein-L-Isoaspartate(D-Aspartate) O-Methyltransferase (PCMT1; PIMT) Inhibitors;Epigenetic Modifier Modulators Replicase Polyprotein 1ab (pp1ab) (SARS) Coronavirus (SARS-associated) IC-50 3.83E-07 M
Noscapine Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Tubulin Polymerization Inhibitors;Apoptosis Inducers;Antimitotic Drugs Severe acute respiratory syndrome (SARS-CoV) Cell counting assay Vero African green monkey kidney cells IC-50 4.00E-07 g/l
Isobavachalcone Tyrosinase (Tyr) inhibition, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Tyrosinase (Tyr) Thiouracil incorporation assay Melanocytes, human IC-50 4.00E-07 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) Dye assay (MTT) MCF7 human breast adenocarcinoma cells (hormone-dependent) CC-50 4.00E-07 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Cell counting assay PC3 human prostate adenocarcinoma cells MIC 4.00E-07 M
Tingenone Hepatoblastoma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Hepatoblastoma Dye assay (alamar blue) HepG2 human hepatoblastoma cells CC-50 4.00E-07 M
Tingenone Leukemia, acute promyelocytic (M3) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Leukemia, acute promyelocytic (M3) Dye assay (alamar blue) HL60 human acute promyelocytic leukemia cells CC-50 4.00E-07 M
Baicalein ATP-Dependent DNA Helicases inhibition, IN VITRO Drugs Targeting on Quorum Sensing Signaling;Signal Transduction Modulators;AR Expression Inhibitors;15-Lipoxygenase Inhibitors;Autophagy Inducers;12-Lipoxygenase Inhibitors;Dual Specificity Protein Phosphatase 3 (VHR) Inhibitors;Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors;Apoptosis Inducers;Protein Tyrosine Phosphatase (PTP) Inhibitors ATP-Dependent DNA Helicases Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) IC-50 4.70E-07 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Flow cytometry assay HEK293 human embryonic kidney cells (ABCB1-overexpressing) MEC <= 5.00E-07 M
Pristimerine Hypoxia Inducible Factor 1-alpha (HIF-1alpha) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Hypoxia Inducible Factor 1-alpha (HIF-1alpha) ELISA assay PC3 human prostate adenocarcinoma cells MIC <= 5.00E-07 M
Pristimerine Hypoxia Inducible Factor (HIF) (nonspecified subtype) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Hypoxia Inducible Factor (HIF) (nonspecified subtype) ELISA assay PC3 human prostate adenocarcinoma cells MIC <= 5.00E-07 M
MAC-5576 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Coronavirus (SARS-associated) IC-50 5.00E-07 M
Ferruginol Catenin beta-1 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Catenin beta-1 Chemiluminescent assay Hippocampus (dorsal), mouse (beta-amyloid (42)-treated) MEC 5.00E-07 M
Ferruginol Glycogen Synthase Kinase 3 beta (GSK-3beta) induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Glycogen Synthase Kinase 3 beta (GSK-3beta) Chemiluminescent assay Hippocampus (dorsal), mouse (beta-amyloid (42)-treated) MEC 5.00E-07 M
Pristimerine Survivin (BIRC5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Survivin (BIRC5) RNA assay OMM1 human uveal melanoma cells MIC <= 5.00E-07 M
Pristimerine MMP-9 (Gelatinase B) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs MMP-9 (Gelatinase B) OMM1 human uveal melanoma cells MIC 5.00E-07 M
Pristimerine Caspase-9 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-9 Acetyl-LEHD-p-nitroaniline as a substrate COLO205 human colon carcinoma cells MEC <= 5.00E-07 M
Pristimerine Caspase-8 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-8 Acetyl-IETD-p-nitroaniline as a substrate COLO205 human colon carcinoma cells MEC <= 5.00E-07 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Dye assay (MTT) PC3 human prostate adenocarcinoma cells (hypoxic) MCC <= 5.00E-07 M
Tingenone Leukemia, acute promyelocytic (M3) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Leukemia, acute promyelocytic (M3) Dye assay (MTT) HL60 human acute promyelocytic leukemia cells CC-50 5.00E-07 M
Tingenone Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Cancer, breast (adenocarcinoma) Dye assay (alamar blue) MCF7 human breast adenocarcinoma cells (hormone-dependent) CC-50 5.00E-07 M
Tingenone Leukemia, myeloid remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Leukemia, myeloid Dye assay (alamar blue) K562 human myeloid leukemia cells CC-50 5.00E-07 M
Tingenone Melanoma, metastatic remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Melanoma, metastatic Dye assay (alamar blue) B16F10 mouse metastatic melanoma cells CC-50 5.00E-07 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Wound closure assay OMM1 human uveal melanoma cells MIC 5.00E-07 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Propidium iodide assay HCT116 human colon carcinoma cells MEC <= 5.00E-07 M
Pristimerine Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon (adenocarcinoma) Propidium iodide assay SW620 human colon adenocarcinoma cells MEC <= 5.00E-07 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Propidium iodide assay COLO205 human colon carcinoma cells MEC <= 5.00E-07 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Flow cytometry assay Mitochondria (COLO205 human colon carcinoma cells) MEC <= 5.00E-07 M
6',6'-Difluoroaristeromycin Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO S-Adenosyl-L-Homocysteine Hydrolase Inhibitors Severe acute respiratory syndrome (SARS-CoV) Dye assay (MTS) VeroE6 African green monkey kidney cells IC-50 5.00E-07 M
JMF-1521 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) Ki 5.20E-07 M
Pristimerine Cancer, rhinopharyngeal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, rhinopharyngeal Dye assay (MTT) KBv200 human epidermoid carcinoma cells (multidrug-resistant/ABCB1-overexpressing) CC-50 5.20E-07 M
Pristimerine Cancer, rhinopharyngeal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, rhinopharyngeal Dye assay (MTT) KB human epidermoid rhinopharyngeal carcinoma cells CC-50 5.40E-07 M
Pristimerine Melanoma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma MDAMB435 human melanoma cells CC-50 5.50E-07 M
GRL-0617 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 5.60E-07 M
TG-0205221 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-50 6.00E-07 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Dye assay (alamar blue) Mononuclear cells (blood), human CC-50 6.00E-07 M
GRL-0617 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Ubiquitin-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 6.00E-07 M
GC-373 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO 3C-Like Protease (Norovirus) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) IC-50 6.00E-07 M
Tingenone Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Cancer, colon Dye assay (alamar blue) HCT116 human colon carcinoma cells CC-50 6.00E-07 M
Tingenone Cancer, mouth (squamous cell) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Cancer, mouth (squamous cell) Dye assay (alamar blue) SCC4 human oral squamous cell carcinoma cells CC-50 6.00E-07 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Dye assay (MTS) MiaPaCa2 human pancreas adenocarcinoma cells MCC <= 6.25E-07 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Flow cytometry assay PANC1 human pancreas adenocarcinoma cells MEC <= 6.25E-07 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Flow cytometry assay MiaPaCa2 human pancreas adenocarcinoma cells MEC <= 6.25E-07 M
Betulonic acid Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Lysosomal alpha-Glucosidase (GAA) Inhibitors;E3 Ubiquitin-Protein Ligase Inhibitors Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-50 6.30E-07 M
Pristimerine Cancer, stomach (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, stomach (adenocarcinoma) Dye assay (MTT) SGC7901 human gastric adenocarcinoma cells IC-50 6.30E-07 M
GRL-0667 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 6.70E-07 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Dye assay (MTT) HEK293 human embryonic kidney cells CC-50 6.90E-07 M
Betulinic acid Infection, herpes simplex virus remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Signal Transduction Modulators;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, herpes simplex virus Viral replication assay Vero African green monkey kidney cells IC-50 7.00E-07 M
Tanshinone I Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Signal Transduction Modulators;AP-1 Transcription Factor Complex Inhibitors;Aryl Hydrocarbon Receptor (AhR) Ligands Replicase Polyprotein 1ab (pp1ab) (SARS) Ubiquitin-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 7.00E-07 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) ATP assay MCF7 human breast adenocarcinoma cells (hormone-dependent) CC-50 7.50E-07 M
Pristimerine Hepatoblastoma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Hepatoblastoma Dye assay (MTT) HepG2 human hepatoblastoma cells IC-50 7.80E-07 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) Spheres formation assay MCF7 human breast adenocarcinoma cells (hormone-dependent) (mammospheres) MIC 7.80E-07 M
Iguesterin Proteasome Subunit beta Type-5 (PSMB5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors Proteasome Subunit beta Type-5 (PSMB5) Fluorescent assay Coronavirus (SARS-associated) Ki 8.00E-07 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Dye assay (MTT) @ 48 h COLO205 human colon carcinoma cells IC-50 8.40E-07 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) Dye assay (MTT) MCF7 human breast adenocarcinoma cells (hormone-dependent) CC-50 8.70E-07 M
Ferruginol Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Malaria Erythrocytes, human IC-50 9.00E-07 M
Geldanamycin Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Signal Transduction Modulators;Heat Shock Protein 90 (Hsp90) Inhibitors Severe acute respiratory syndrome (SARS-CoV) IC-50 9.10E-07 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Dye assay (MTT) HEK293 human embryonic kidney cells (ABCB1-overexpressing) CC-50 9.30E-07 M
NSC-158362 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay MA104 embryonic African green monkey kidney cells IC-50 < 1.00E-06 M
NSC-158362 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-50 < 1.00E-06 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Flow cytometry assay HEK293 human embryonic kidney cells MEC 1.00E-06 M
Ribavirin Nephrotoxicity induction, IN VITRO Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors;Equilibrative Nucleoside Transporter ENT1 Inhibitors Nephrotoxicity Cell viability assay Vero African green monkey kidney cells CC-50 > 1.00E-06 g/l
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Dye assay (MTS) RAW264.7 mouse macrophages MCC 1.00E-06 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Dye assay (MTS) RAW264.7 mouse macrophages MEC 1.00E-06 M
Betulinic acid Cytotoxicity induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cytotoxicity Dye assay (MTT) Macrophage cells (bone marrow), mouse MCC <= 1.00E-06 M
Pristimerine Sphingosine Kinase 1 (SPK1) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Sphingosine Kinase 1 (SPK1) ELISA assay PC3 human prostate adenocarcinoma cells (hypoxic) MIC 1.00E-06 M
Isobavachalcone Interleukin-6 (IL-6) inhibition, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Interleukin-6 (IL-6) Chemiluminescent assay BV2 murine microglia cells MIC 1.00E-06 M
Pristimerine Multidrug Resistance Protein 1 (MDR-1) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Multidrug Resistance Protein 1 (MDR-1) Flow cytometry assay HEK293 human embryonic kidney cells (ABCB1-overexpressing) MIC 1.00E-06 M
Betulinic acid DNA Topoisomerase II (nonspecified subtype) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors DNA Topoisomerase II (nonspecified subtype) DNA relaxation assay Human enzyme IC-50 > 1.00E-06 M
Psoralidin 5-Hydroxytryptamine Receptor 1A (5-HT1A) agonism, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers 5-Hydroxytryptamine Receptor 1A (5-HT1A) Chemiluminescent assay Cortical neurons (primary), mouse MEC <= 1.00E-06 M
JMF-1521 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) IC-50 1.00E-06 M
Pristimerine Survivin (BIRC5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Survivin (BIRC5) RNA assay 92.1 human uveal melanoma cells MIC 1.00E-06 M
Pristimerine Caspase-3 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-3 Acetyl-DEVD-p-nitroaniline as a substrate HCT116 human colon carcinoma cells MEC 1.00E-06 M
Pristimerine Caspase-3 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-3 Acetyl-DEVD-p-nitroaniline as a substrate SW620 human colon adenocarcinoma cells MEC 1.00E-06 M
Pristimerine Caspase-3 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-3 Acetyl-DEVD-p-nitroaniline as a substrate COLO205 human colon carcinoma cells MEC 1.00E-06 M
Pristimerine Caspase-9 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-9 Acetyl-LEHD-p-nitroaniline as a substrate HCT116 human colon carcinoma cells MEC 1.00E-06 M
Pristimerine Caspase-9 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-9 Acetyl-LEHD-p-nitroaniline as a substrate SW620 human colon adenocarcinoma cells MEC 1.00E-06 M
Pristimerine Caspase-8 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-8 Acetyl-IETD-p-nitroaniline as a substrate SW620 human colon adenocarcinoma cells MEC 1.00E-06 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Dye assay (MTT) PC3 human prostate adenocarcinoma cells MCC 1.00E-06 M
Isobavachalcone Neuroinflammation remission/reduction, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Neuroinflammation Nitrite assay BV2 murine microglia cells MIC 1.00E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Flow cytometry assay 92.1 human uveal melanoma cells MEC <= 1.00E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Flow cytometry assay OMM1 human uveal melanoma cells MEC <= 1.00E-06 M
Isobavachalcone Dementia, Alzheimer type protection, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Dementia, Alzheimer type Dye assay (MTT) SHSY5Y human dopaminergic neuroblastoma cells MIC <= 1.00E-06 M
Psoralidin Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Cancer, breast (adenocarcinoma) Dye assay (MTT) MDAMB231 human breast adenocarcinoma cells (ALDH-positive) MCC <= 1.00E-06 M
Betulinic acid Osteoporosis remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Osteoporosis Spectrophotometric assay Macrophage cells (bone marrow), mouse IC-50 <= 1.00E-06 M
Betulinic acid Cytotoxicity remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cytotoxicity Dye assay (MTT) hFOB1.19 human fetal osteoblasts (SV40 large Tantigen-transformed) MCC <= 1.00E-06 M
Betulinic acid Cytotoxicity remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cytotoxicity Dye assay (MTT) hFOB1.19 human fetal osteoblasts (SV40 large Tantigen-transformed) MCC <= 1.00E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Dye assay (MTT) @ 72 h MDAMB231 human breast adenocarcinoma cells MIC <= 1.00E-06 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Flow cytometry assay Mitochondria (HCT116 human colon carcinoma cells) MEC 1.00E-06 M
Pristimerine Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon (adenocarcinoma) Flow cytometry assay Mitochondria (SW620 human colon adenocarcinoma cells) MEC 1.00E-06 M
Mucroporin-M1 Cytotoxicity induction, IN VITRO Cell Membrane Disrupting Agents Cytotoxicity Dye assay (MTT) MDBK Madin-Darby bovine kidney epithelial cells CC-50 1.03E-06 M
Psoralidin Estrogen Receptor alpha (ERalpha) affinity, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Estrogen Receptor alpha (ERalpha) Displacement of [3H]-estradiol Recombinant human receptor IC-50 1.03E-06 M
Pristimerine Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, lung (non-small cell) (NSCLC) Dye assay (MTT) A549 human non-small-cell lung carcinoma cells IC-50 1.03E-06 M
Pristimerine Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon (adenocarcinoma) Dye assay (MTT) @ 48 h SW620 human colon adenocarcinoma cells IC-50 1.04E-06 M
Betulinic acid G-Protein Coupled Bile Acid Receptor BG37 (TGR5) agonism, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors G-Protein Coupled Bile Acid Receptor BG37 (TGR5) Gene reporter assay CHO Chinese hamster ovary cells transfected with human GPBA (TGR5) receptor EC-50 1.10E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Dye assay (MTS) 92.1 human uveal melanoma cells CC-50 1.10E-06 M
(-)-Savinin Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Drugs Acting on Tumor Necrosis Factor (TNF) Receptors Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-50 1.13E-06 M
Pristimerine Cancer, liver (hepatocellular carcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, liver (hepatocellular carcinoma) Dye assay (MTT) BEL7402 human hepatocellular carcinoma cells IC-50 1.16E-06 M
DTPMPA ATPase (nonspecified subtype) inhibition, IN VITRO Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors ATPase (nonspecified subtype) Phosphate release assay Coronavirus (SARS-associated) IC-50 1.19E-06 M
Dihydrotan Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Hypoxia Inducible Factor 1-alpha (HIF-1alpha) Inhibitors;Immune Checkpoint Inhibitors;Indoleamine 2,3-dioxygenase 1 (IDO1; IDO) Inhibitors;Acetylcholinesterase (AChE) Inhibitors;Nitric Oxide (NO) Production Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Ubiquitin-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 1.20E-06 M
Pristimerine Cancer, colon remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, colon Dye assay (MTT) @ 48 h HCT116 human colon carcinoma cells IC-50 1.22E-06 M
SR9EK3 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-90 1.23E-06 M
Pristimerine Cancer, pancreas (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, pancreas (adenocarcinoma) Dye assay (MTS) PANC1 human pancreas adenocarcinoma cells MCC 1.25E-06 M
Pristimerine Cancer, endometrium (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, endometrium (adenocarcinoma) Flow cytometry assay MDAH2774 human endometrium adenocarcinoma cells MEC 1.25E-06 M
Pristimerine Cancer, prostate remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate Dye assay (MTS) LNCaP human prostate carcinoma cells (androgen-dependent) MCC 1.25E-06 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Dye assay (MTS) PC3 human prostate adenocarcinoma cells MCC 1.25E-06 M
Pristimerine Cancer, prostate remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate Flow cytometry assay LNCaP human prostate carcinoma cells (androgen-dependent) MEC 1.25E-06 M
Pristimerine Cancer, prostate (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, prostate (adenocarcinoma) Flow cytometry assay PC3 human prostate adenocarcinoma cells MEC 1.25E-06 M
Pristimerine Sarcoma, synovial remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Sarcoma, synovial Dye assay (MTT) SW982 human synovial sarcoma cells CC-50 1.28E-06 M
Ferruginol Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Malaria IC-50 1.33E-06 M
Isobavachalcone Dihydroorotate Dehydrogenase (quinone), mitochondrial (DHODH) affinity, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Dihydroorotate Dehydrogenase (quinone), mitochondrial (DHODH) Isothermal microcalorimetric test Recombinant human enzyme Kd 1.33E-06 M
Ferruginol Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Severe acute respiratory syndrome (SARS-CoV) Cytopathicity assay Vero African green monkey kidney cells IC-50 1.39E-06 M
Ferroquine Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Vero African green monkey kidney cells IC-50 1.40E-06 M
Betulinic acid Infection, HIV remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, HIV Antigen assay H9 human T-cell leukemia cells IC-50 1.40E-06 M
Betulinic acid Infection, HIV remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, HIV Viral replication assay H9 human T-cell leukemia cells IC-50 1.40E-06 M
Ferruginol Fatty acid oxidation disorders remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Fatty acid oxidation disorders TBARS formation assay Erythrocytes, human IC-50 1.40E-06 M
Betulinic acid Infection, HIV remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, HIV Viral replication assay H9 human T-cell leukemia cells IC-50 1.40E-06 M
Betulinic acid Infection, HIV remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, HIV Viral replication assay H9 human T-cell leukemia cells IC-50 1.40E-06 M
Isobavachalcone Cancer remission/reduction, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Cancer Endothelial cells (lymphatic), rat (temperature-sensitive) IC-50 1.41E-06 M
Betulinic acid Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Signal Transduction Modulators;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Malaria Fluorescent assay Erythrocytes, human IC-50 1.42E-06 M
Betulinic acid Malaria remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;Apoptosis Inducers;NF-kappaB (NFKB) Activators;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Malaria Fluorescent assay Erythrocytes, human IC-50 1.42E-06 M
ML-188 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Coronavirus (SARS-associated) IC-50 1.50E-06 M
ML-188 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Coronavirus (SARS-associated) IC-50 1.50E-06 M
Betulinic acid Osteoporosis remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Osteoporosis Tartrate-resistant acid phosphatase assay Macrophage cells (bone marrow), mouse IC-50 1.60E-06 M
Sinefungin RNA (Guanine-7-) Methyltransferase inhibition, IN VITRO Coactivator Associated Arginine Methyltransferase 1 (CARM1; PRMT4) Inhibitors;Histone-Lysine N-Methyltransferase SETD7 (SET7/9) Inhibitors;Protein-L-Isoaspartate(D-Aspartate) O-Methyltransferase (PCMT1; PIMT) Inhibitors;Epigenetic Modifier Modulators RNA (Guanine-7-) Methyltransferase Yeast-based assay Coronavirus (SARS-associated) IC-50 1.62E-06 M
SR9EK3 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-99 1.63E-06 M
Betulinic acid alpha-1 Adrenergic Receptors (nonspecified subtype) antagonism, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors alpha-1 Adrenergic Receptors (nonspecified subtype) Artery (aorta, thoracic), rat IC-50 1.67E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Dye assay (MTS) Mel270 human uveal melanoma cells CC-50 1.70E-06 M
Betulinic acid Cancer, stomach remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, stomach Colony formation assay GES-1 human gastric epithelial cells (methyl-N-nitroso-guanidine-treated) IC-50 1.72E-06 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) ATP assay MCF7 human breast adenocarcinoma cells (hormone-dependent) (mammospheres) CC-50 1.75E-06 M
Psoralidin Estrogen Receptor (nonspecified subtype) agonism, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Estrogen Receptor (nonspecified subtype) Luciferine/luciferase assay MCF7 human breast adenocarcinoma cells (hormone-dependent) EC-50 1.85E-06 M
Betulinic acid Aldo-Keto Reductase Family 1 Member B10 (ARL-1) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Aldo-Keto Reductase Family 1 Member B10 (ARL-1) Fluorescent assay IC-50 2.00E-06 M
Pristimerine Caspase-8 activation, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Caspase-8 Acetyl-IETD-p-nitroaniline as a substrate HCT116 human colon carcinoma cells MEC 2.00E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Flow cytometry assay Mel270 human uveal melanoma cells MEC 2.00E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Flow cytometry assay OMM2.3 human uveal melanoma cells MEC 2.00E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Dye assay (MTS) OMM1 human uveal melanoma cells CC-50 2.20E-06 M
Betulinic acid Oxidative stress remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Oxidative stress Ferricytochrome c reduction assay Neutrophils, human IC-50 2.23E-06 M
Betulinic acid G-Protein Coupled Bile Acid Receptor BG37 (TGR5) agonism, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors G-Protein Coupled Bile Acid Receptor BG37 (TGR5) cAMP accumulation assay HEK293 human embryonic kidney cells transfected with human GPBA (TGR5) receptor EC-50 2.25E-06 M
Kaempferol 3-O-alpha-L-arabinofuranoside Hypothetical Protein Sars3a inhibition, IN VITRO Hedgehog Signaling Inhibitors;Antioxidants Hypothetical Protein Sars3a Voltage-clamp assay (-60 mV) Oocytes (Xenopus) transfected with SARS associated coronavirus 3a protein IC-50 2.30E-06 M
Bananin ATPase (nonspecified subtype) inhibition, IN VITRO Chelating Agents ATPase (nonspecified subtype) Coronavirus (SARS-associated) IC-50 2.30E-06 M
Dieckol 3C-Like Protease (viral) inhibition, IN VITRO Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors;beta-Secretase 1 (BACE1) Inhibitors;Acetylcholinesterase (AChE) Inhibitors 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) Ki 2.40E-06 M
Betulinic acid Osteoporosis remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Osteoporosis Macrophage cells (bone marrow), mouse IC-50 <= 2.40E-06 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) Cell counting assay SKBr3 human breast adenocarcinoma cells (HER2 [ERBB2]-overexpressing) CC-50 2.40E-06 M
Isobavachalcone Signal Transducer and Activator of Transcription 3 (STAT3) inhibition, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Signal Transducer and Activator of Transcription 3 (STAT3) Luciferine/luciferase assay Hep3B human hepatocellular carcinoma cells IC-50 2.45E-06 M
Ferruginol Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Malaria IC-50 2.47E-06 M
Betulinic acid HIV-1 Protease inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors HIV-1 Protease HIV IC-50 2.50E-06 M
Betulinic acid Zinc Finger and BTB Domain Containing 10 induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Zinc Finger and BTB Domain Containing 10 Luciferine/luciferase assay MDAMB231 human breast adenocarcinoma cells MEC 2.50E-06 M
Betulinic acid SP Transcritption Factors inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors SP Transcritption Factors Luciferine/luciferase assay MDAMB231 human breast adenocarcinoma cells MIC 2.50E-06 M
Betulinic acid MicroRNA 27a inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors MicroRNA 27a RNA assay MDAMB231 human breast adenocarcinoma cells MIC 2.50E-06 M
Betulinic acid Vascular Endothelial Growth Factors (VEGF) (nonspecified subtype) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Vascular Endothelial Growth Factors (VEGF) (nonspecified subtype) Luciferine/luciferase assay MDAMB231 human breast adenocarcinoma cells MIC 2.50E-06 M
Betulinic acid Vascular Endothelial Growth Factor Receptor (VEGFR) (nonspecified subtype) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Vascular Endothelial Growth Factor Receptor (VEGFR) (nonspecified subtype) Luciferine/luciferase assay MDAMB231 human breast adenocarcinoma cells MIC 2.50E-06 M
Pristimerine Cancer, ovary remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, ovary Flow cytometry assay OVCAR5 human ovary carcinoma cells MEC 2.50E-06 M
Pristimerine Cancer, ovary remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, ovary Flow cytometry assay Mitochondria (OVCAR5 human ovary carcinoma cells) MEC 2.50E-06 M
Pristimerine Cancer, endometrium (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, endometrium (adenocarcinoma) Flow cytometry assay Mitochondria (MDAH2774 human endometrium adenocarcinoma cells) MEC 2.50E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Flow cytometry assay MCF7 human breast adenocarcinoma cells (hormone-dependent) MEC <= 2.50E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Flow cytometry assay MDAMB231 human breast adenocarcinoma cells MIC <= 2.50E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Flow cytometry assay MCF7 human breast adenocarcinoma cells (hormone-dependent) MIC <= 2.50E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Flow cytometry assay MDAMB231 human breast adenocarcinoma cells MIC <= 2.50E-06 M
Betulinic acid Cancer, breast remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast Cell counting assay MDAMB453 human breast carcinoma cells MIC 2.50E-06 M
Betulinic acid Melanoma remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Melanoma Cell counting assay MDAMB435 human melanoma cells MIC 2.50E-06 M
Betulinic acid Cancer, breast remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast Cell counting assay MDAMB453 human breast carcinoma cells MIC 2.50E-06 M
Betulinic acid Cancer, breast remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast Cell counting assay MDAMB468 human breast carcinoma cells MIC 2.50E-06 M
Betulinic acid Cancer, breast remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast Cell counting assay Hs578T human breast carcinoma cells MIC 2.50E-06 M
Betulinic acid Cancer, breast (in situ ductal carcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (in situ ductal carcinoma) Cell counting assay BT474 human breast ductal carcinoma cells (HER2 [ERBB2]-overexpressing) MIC 2.50E-06 M
Pristimerine Glioma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Glioma Dye assay (MTT) C6 rat glioma cells CC-50 2.50E-06 M
Iguesterin Proteasome Subunit beta Type-5 (PSMB5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors Proteasome Subunit beta Type-5 (PSMB5) Fluorescent assay Coronavirus (SARS-associated) IC-50 2.60E-06 M
Dieckol 3C-Like Protease (viral) inhibition, IN VITRO Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors;beta-Secretase 1 (BACE1) Inhibitors;Acetylcholinesterase (AChE) Inhibitors 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) IC-50 2.70E-06 M
Ferruginol Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Malaria IC-50 2.90E-06 M
Pristimerine Cancer, mouth (squamous cell) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, mouth (squamous cell) Dye assay (alamar blue) HSC3 human oral squamous cell carcinoma cells CC-50 2.90E-06 M
Pristimerine Melanoma, uveal remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, uveal Dye assay (MTS) OMM2.3 human uveal melanoma cells CC-50 2.90E-06 M
Hirsutenone Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;LDL Antioxidants;Signal Transduction Modulators;Antiinflammatory Drugs;Free Radical Scavengers;Nitric Oxide (NO) Production Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Ubiquitin-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 3.00E-06 M
Bananin ATP-Dependent DNA Helicases inhibition, IN VITRO Chelating Agents ATP-Dependent DNA Helicases Coronavirus (SARS-associated) IC-50 3.00E-06 M
Tingenone Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Cancer, breast (adenocarcinoma) Dye assay (MTT) MCF7 human breast adenocarcinoma cells (hormone-dependent) CC-50 3.00E-06 M
Betulinic acid Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, lung (non-small cell) (NSCLC) Dye assay (MTT) A549 human non-small-cell lung carcinoma cells CC-50 3.00E-06 M
Pristimerine Proteasome Subunit beta Type-5 (PSMB5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Proteasome Subunit beta Type-5 (PSMB5) Fluorescent assay Coronavirus (SARS-associated) Ki 3.10E-06 M
Pristimerine Leukemia, myeloid remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Leukemia, myeloid K562 human myeloid leukemia cells CC-50 3.20E-06 M
Pristimerine HLA Class I Histocompatibility antigen, B-7 alpha chain (HLA-B) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs HLA Class I Histocompatibility antigen, B-7 alpha chain (HLA-B) Luciferine/luciferase assay HeLa human cervix adenocarcinoma cells IC-50 3.25E-06 M
Betulinic acid Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, colon (adenocarcinoma) Dye assay (MTT) HT29 human colon adenocarcinoma cells IC-50 3.40E-06 M
Pristimerine Cancer, cervix, (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, cervix, (adenocarcinoma) Dye assay (MTT) HeLa human cervix adenocarcinoma cells CC-50 3.42E-06 M
GC-373 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (Norovirus) Inhibitors 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) IC-50 3.48E-06 M
GC-373 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (Norovirus) Inhibitors 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) IC-50 3.48E-06 M
Betulinic acid Protein Tyrosine Phosphatase 1B (PTP-1B) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Protein Tyrosine Phosphatase 1B (PTP-1B) p-Nitrophenyl phosphate as substrate IC-50 3.49E-06 M
Pristimerine Cytotoxicity induction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cytotoxicity Dye assay (alamar blue) MRC5 human embryonic lung fibroblasts CC-50 3.50E-06 M
Psoralidin Lysosomal alpha-Glucosidase inhibition, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Lysosomal alpha-Glucosidase p-Nitrophenyl alpha-D-glucopyranoside as substrate IC-50 3.50E-06 M
Mucroporin-M1 Influenza A remission/reduction, IN VITRO Cell Membrane Disrupting Agents Influenza A Plaque assay IC-50 3.52E-06 M
SR9EK2 Nephrotoxicity induction, IN VITRO Nephrotoxicity Dye assay Vero African green monkey kidney cells CC-50 3.60E-06 M
Betulinic acid Infection, cytomegalovirus remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Signal Transduction Modulators;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, cytomegalovirus Fluorescent assay Fibroblasts (foreskin), human IC-50 3.62E-06 M
Betulinic acid Infection, cytomegalovirus remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;Apoptosis Inducers;NF-kappaB (NFKB) Activators;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, cytomegalovirus Fluorescent assay Fibroblasts (foreskin), human IC-50 3.62E-06 M
Psoralidin Estrogen Receptor alpha (ERalpha) agonism, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Estrogen Receptor alpha (ERalpha) Luciferine/luciferase assay CV1 African green monkey kidney fibroblasts transfected with ERalpha receptor EC-50 3.68E-06 M
Betulinic acid Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Signal Transduction Modulators;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Malaria Radioactivity assay IC-50 3.70E-06 M
Papyriflavonol A Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Signal Transduction Modulators;Phospholipase A2 (PLA2) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Fluorescent assay Coronavirus (SARS-associated) IC-50 3.70E-06 M
Noscapine Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Tubulin Polymerization Inhibitors;Apoptosis Inducers;Antimitotic Drugs Severe acute respiratory syndrome (SARS-CoV) Dye assay (neutral red) Vero African green monkey kidney cells IC-50 3.80E-06 g/l
Psoralidin Cytotoxicity induction, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Cytotoxicity Dye assay (MTT) RWPE1 human prostate epithelial cells MCC 4.00E-06 M
Tingenone Proteasome Subunit beta Type-5 (PSMB5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Antioxidants;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs;Free Radical Scavengers Proteasome Subunit beta Type-5 (PSMB5) Fluorescent assay Coronavirus (SARS-associated) Ki 4.00E-06 M
Psoralidin Cancer, prostate remission/reduction, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Cancer, prostate Bromodeoxyuridine incorporation assay Epithelial cells (prostate), human (cadmium-transformed) MIC 4.00E-06 M
Chloroquine phosphate Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Apoptosis Inducers Severe acute respiratory syndrome (SARS-CoV) Viral replication assay Vero African green monkey kidney cells IC-50 4.10E-06 M
Chloroquine phosphate Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Apoptosis Inducers Severe acute respiratory syndrome (SARS-CoV) Dye assay (MTS) VeroE6 African green monkey kidney cells IC-50 4.10E-06 M
Chloroquine phosphate Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Apoptosis Inducers Severe acute respiratory syndrome (SARS-CoV) Viral replication assay IC-50 4.10E-06 M
Hirsutenone 3C-Like Protease (viral) inhibition, IN VITRO Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;LDL Antioxidants;Signal Transduction Modulators;Antiinflammatory Drugs;Free Radical Scavengers;Nitric Oxide (NO) Production Inhibitors 3C-Like Protease (viral) Fluorescent assay Coronavirus (SARS-associated) IC-50 4.10E-06 M
Hirsutenone Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;LDL Antioxidants;Signal Transduction Modulators;Antiinflammatory Drugs;Free Radical Scavengers;Nitric Oxide (NO) Production Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 4.10E-06 M
ML-300 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors 3C-Like Protease (viral) Coronavirus (SARS-associated) IC-50 4.11E-06 M
(-)-Savinin Cancer, ovary (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Drugs Acting on Tumor Necrosis Factor (TNF) Receptors Cancer, ovary (adenocarcinoma) Dye assay (sulforhodamine B) SKOV3 human ovary adenocarcinoma cells CC-50 4.16E-06 M
Tripterin Proteasome Subunit beta Type-5 (PSMB5) inhibition, IN VITRO Signal Transduction Modulators;Heat Shock Protein 90 (Hsp90) Inhibitors;Lipid Peroxidation Inhibitors;Cytokine Production Inhibitors;Apoptosis Inducers;Enoyl-(Acyl Carrier Protein) Reductase (FabI) (Plasmodium falciparum) Inhibitors;Antioxidants;Myc Proto-Oncogene Protein (c-Myc)/Myc-Associated Factor X (Max) Interaction Inhibitors Proteasome Subunit beta Type-5 (PSMB5) Fluorescent assay Coronavirus (SARS-associated) Ki 4.20E-06 M
Psoralidin Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 4.20E-06 M
GC-376 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (Norovirus) Inhibitors 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) IC-50 4.35E-06 M
GC-376 3C-Like Protease (viral) inhibition, IN VITRO 3C-Like Protease (Norovirus) Inhibitors 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) IC-50 4.35E-06 M
(-)-Savinin Melanoma remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Drugs Acting on Tumor Necrosis Factor (TNF) Receptors Melanoma Dye assay (sulforhodamine B) SKMEL2 human melanoma cells CC-50 4.37E-06 M
Pristimerine Glioblastoma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Glioblastoma Dye assay (MTT) U251 human glioblastoma cells CC-50 4.50E-06 M
Betulinic acid Cytotoxicity induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cytotoxicity Dye assay (MTT) HeLa human cervix adenocarcinoma cells (CD4+/CCR5+) transfected with HIV-1 LTRbeta-gal-positive CC-50 4.52E-06 M
Betulinic acid Cytotoxicity induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cytotoxicity Dye assay (MTT) HeLa human cervix adenocarcinoma cells (CD4+/CCR5+) transfected with HIV-1 LTRbeta-gal-positive CC-50 4.52E-06 M
Xanthoangelol B Anemia, hemolytic remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Cysteine Protease Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants;Sensor Histidine Kinase (Bacterial) Inhibitors;Plasminogen Activator Inhibitor (PAI-1) Inhibitors;Nitric Oxide (NO) Production Inhibitors;Free Radical Scavengers Anemia, hemolytic Erythrocytes, human IC-50 4.62E-06 M
(-)-Savinin Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Drugs Acting on Tumor Necrosis Factor (TNF) Receptors Cancer, colon (adenocarcinoma) Dye assay (sulforhodamine B) HCT15 human colon adenocarcinoma cells CC-50 4.82E-06 M
Imatinib mesylate Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Tyrosine-Protein Kinase ABL1 Inhibitors;Bcr-Abl (Bcr-Abl1) Kinase Inhibitors;PDGFRalpha Inhibitors;PDGFRbeta Inhibitors;Signal Transduction Modulators;Breast Cancer-Resistant Protein (BCRP; ABCG2) Inhibitors;KIT (C-KIT) Inhibitors;CSF1R (c-FMS) Inhibitors;Apoptosis Inducers;Angiogenesis Inhibitors Severe acute respiratory syndrome (SARS-CoV) RNA assay Calu3 human lung carcinoma cells (c-erbB2-overexpressing) MIC > 5.00E-06 M
Betulinic acid DNA Topoisomerase II alpha inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors DNA Topoisomerase II alpha DNA decatenation assay Human enzyme IC-50 5.00E-06 M
Psoralidin Activity-Regulated Cytoskeleton-Associated Protein activation, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Activity-Regulated Cytoskeleton-Associated Protein RNA assay Cortical neurons (primary), mouse MEC 5.00E-06 M
Psoralidin Early Growth Response 1 (EGR1) induction, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Early Growth Response 1 (EGR1) RNA assay Cortical neurons (primary), mouse MEC 5.00E-06 M
Betulinic acid Caveolin 1 (CAV1) induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Caveolin 1 (CAV1) Chemiluminescent assay MDAMB231 human breast adenocarcinoma cells MEC 5.00E-06 M
Betulinic acid L-Lactate Dehydrogenase A chain (LDH-A) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors L-Lactate Dehydrogenase A chain (LDH-A) Chemiluminescent assay MCF7 human breast adenocarcinoma cells (hormone-dependent) MIC 5.00E-06 M
Betulinic acid [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase isozyme 1, mitochondrial (PDK1) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase isozyme 1, mitochondrial (PDK1) Chemiluminescent assay MCF7 human breast adenocarcinoma cells (hormone-dependent) MIC 5.00E-06 M
Betulinic acid [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase isozyme 1, mitochondrial (PDK1) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase isozyme 1, mitochondrial (PDK1) Chemiluminescent assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase isozyme 1, mitochondrial (PDK1) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase isozyme 1, mitochondrial (PDK1) Chemiluminescent assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Transcription Factor p65 inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Transcription Factor p65 Chemiluminescent assay MCF7 human breast adenocarcinoma cells (hormone-dependent) MIC 5.00E-06 M
Betulinic acid Hypoxia Inducible Factor (HIF) (nonspecified subtype) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Hypoxia Inducible Factor (HIF) (nonspecified subtype) ELISA assay PC3 human prostate adenocarcinoma cells MIC <= 5.00E-06 M
Betulinic acid Hypoxia Inducible Factor (HIF) (nonspecified subtype) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Hypoxia Inducible Factor (HIF) (nonspecified subtype) Chemiluminescent assay PC3 human prostate adenocarcinoma cells MIC <= 5.00E-06 M
Pristimerine Fatty Acid Synthase inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Fatty Acid Synthase Acetyl-CoA incorporation assay SKBr3 human breast adenocarcinoma cells (HER2 [ERBB2]-overexpressing) MIC 5.00E-06 M
Cinanserin hydrochloride 3C-Like Protease (viral) inhibition, IN VITRO Serotonin Receptor Antagonists;Signal Transduction Modulators 3C-Like Protease (viral) Coronavirus (SARS-associated) IC-50 5.00E-06 M
Tomentin E Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 5.00E-06 M
Betulinic acid Apoptosis Regulator Bcl-2 induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Apoptosis Regulator Bcl-2 Chemiluminescent assay H9c2 rat cardiac myoblasts (hypoxic/reoxygenated) MEC <= 5.00E-06 M
Betulinic acid Caspase-3 inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Caspase-3 Acetyl-Asp-Glu-Val-Asp-p-nitroanilide as substrate H9c2 rat cardiac myoblasts MIC <= 5.00E-06 M
Betulinic acid Apoptosis Regulator BAX inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Apoptosis Regulator BAX Chemiluminescent assay H9c2 rat cardiac myoblasts MIC <= 5.00E-06 M
Betulinic acid Transcriptional Repressor Protein YY1 inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Transcriptional Repressor Protein YY1 Luciferine/luciferase assay MDAMB453 human breast carcinoma cells MIC 5.00E-06 M
Betulinic acid Membrane-Associated Tyrosine- and Threonine-Specific cdc2-Inhibitory Kinase induction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Membrane-Associated Tyrosine- and Threonine-Specific cdc2-Inhibitory Kinase RNA assay MDAMB231 human breast adenocarcinoma cells MEC 5.00E-06 M
Betulinic acid SP Transcritption Factors inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors SP Transcritption Factors Luciferine/luciferase assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Transcription Factor Sp1 inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Transcription Factor Sp1 RNA assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Transcription Factor Sp3 inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Transcription Factor Sp3 RNA assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Transcription Factor Sp4 inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Transcription Factor Sp4 RNA assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Wee1-Like Protein Kinase 1 (Wee1) inhibition, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Wee1-Like Protein Kinase 1 (Wee1) RNA assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Isobavachalcone Cancer, liver (hepatocellular carcinoma) remission/reduction, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Cancer, liver (hepatocellular carcinoma) Colony formation assay Hep3B human hepatocellular carcinoma cells MIC <= 5.00E-06 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) Flow cytometry assay SKBr3 human breast adenocarcinoma cells (HER2 [ERBB2]-overexpressing) MEC 5.00E-06 M
Betulinic acid Oxidative stress remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Oxidative stress Chemiluminescent assay H9c2 rat cardiac myoblasts MIC <= 5.00E-06 M
Betulinic acid Oxidative stress remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Oxidative stress TBARS formation assay H9c2 rat cardiac myoblasts MIC <= 5.00E-06 M
Betulinic acid Oxidative stress remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Oxidative stress Hydroxylamine as substrate H9c2 rat cardiac myoblasts (hypoxic/reoxygenated) MIC <= 5.00E-06 M
Betulinic acid Oxidative stress remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Oxidative stress Spectrophotometric assay H9c2 rat cardiac myoblasts (hypoxic/reoxygenated) MIC <= 5.00E-06 M
Betulinic acid Oxidative stress remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Oxidative stress Spectrophotometric assay H9c2 rat cardiac myoblasts MIC <= 5.00E-06 M
Betulinic acid Cancer, breast (in situ ductal carcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (in situ ductal carcinoma) Cell counting assay BT474 human breast ductal carcinoma cells (HER2 [ERBB2]-overexpressing) MIC 5.00E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Flow cytometry assay MDAMB231 human breast adenocarcinoma cells MEC 5.00E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Cell counting assay MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Dye assay (MTT) MDAMB231 human breast adenocarcinoma cells MCC 5.00E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Dye assay (MTT) MDAMB231 human breast adenocarcinoma cells MCC 5.00E-06 M
Betulinic acid Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (adenocarcinoma) Dye assay (MTT) @ 24 h MDAMB231 human breast adenocarcinoma cells MIC 5.00E-06 M
Betulinic acid Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, lung (non-small cell) (NSCLC) Transwell chamber assay H1299 human non-small-cell lung cancer cells MIC 5.00E-06 M
Betulinic acid Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, lung (non-small cell) (NSCLC) Wound closure assay H1299 human non-small-cell lung cancer cells MIC 5.00E-06 M
Pristimerine Glioblastoma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Glioblastoma Dye assay (MTT) U87MG human glioblastoma cells CC-50 5.00E-06 M
Betulinic acid Cancer, esophagus remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, esophagus Cell viability assay YES2 human esophagus cancer cells IC-50 5.09E-06 M
Betulinic acid Malaria remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Signal Transduction Modulators;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Malaria Flow cytometry assay Erythrocytes, human IC-50 5.20E-06 M
Betulinic acid Infection, HIV remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, HIV beta-Galactosidase assay HeLa human cervix adenocarcinoma cells (CD4+/CCR5+) transfected with HIV-1 LTRbeta-gal-positive IC-50 5.32E-06 M
Betulinic acid Infection, HIV remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Infection, HIV beta-Galactosidase assay HeLa human cervix adenocarcinoma cells (CD4+/CCR5+) transfected with HIV-1 LTRbeta-gal-positive IC-50 5.32E-06 M
Pristimerine Proteasome Subunit beta Type-5 (PSMB5) inhibition, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Proteasome Subunit beta Type-5 (PSMB5) Fluorescent assay Coronavirus (SARS-associated) IC-50 5.50E-06 M
SSYA-10-001 NTPase inhibition, IN VITRO NTPase Fluorescent assay Coronavirus (SARS-associated) IC-50 5.60E-06 M
Curcumin Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;CCND1 Expression Inhibitors;Glucose-6-Phosphatase Inhibitors;P-Glycoprotein (MDR-1; ABCB1) Inhibitors;HIV Integrase Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Signal Transduction Modulators;Antiinflammatory Drugs;Histone N-Acetyltransferase (HAT) Inhibitors;Microtubule-Associated Protein Tau (PHF-tau; MAPT) Aggregation Inhibitors;AP-1 Transcription Factor Complex Inhibitors;DNA Methyltransferase 1 (DNMT1) Inhibitors;Apoptosis Inducers;Prostaglandin G/H Synthase 1 (PTGS1; COX-1) Inhibitors;Antioxidants;Angiogenesis Inhibitors;EGFR Expression Inhibitors;Cell Division Protein FtsZ (Bacterial) Inhibitors;Free Radical Scavengers;Lipoxygenase Inhibitors;Wnt Signaling Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 5.70E-06 M
RH-01 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO 3C-Like Protease (NL63 Coronavirus) (HCoV-NL63) Inhibitors;3C-Like Protease (EMC Coronavirus) (HCoV-EMC) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Coronavirus IC-50 5.72E-06 M
(-)-Savinin Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Drugs Acting on Tumor Necrosis Factor (TNF) Receptors Cancer, lung (non-small cell) (NSCLC) Dye assay (sulforhodamine B) A549 human non-small-cell lung carcinoma cells CC-50 5.75E-06 M
Ferruginol Leishmaniasis remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Lipid Peroxidation Inhibitors;Antioxidants;Apoptosis Inducers Leishmaniasis Amastigote assay IC-50 5.90E-06 M
Loperamide hydrochloride Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Signal Transduction Modulators;mu-Opioid Receptor Agonists;Atrial Natriuretic Peptide B (NPR2; Guanylate Cyclase B) Receptor Antagonists Severe acute respiratory syndrome (SARS-CoV) Dye assay (MTS) VeroE6 African green monkey kidney cells IC-50 5.90E-06 M
Loperamide hydrochloride Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Signal Transduction Modulators;mu-Opioid Receptor Agonists;Atrial Natriuretic Peptide B (NPR2; Guanylate Cyclase B) Receptor Antagonists Severe acute respiratory syndrome (SARS-CoV) Viral replication assay IC-50 5.90E-06 M
Papyriflavonol A Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Signal Transduction Modulators;Phospholipase A2 (PLA2) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Uncompetitive inhibition mode Coronavirus (SARS-associated) Ki 5.90E-06 M
SG-85 Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO 3C-Like Protease (NL63 Coronavirus) (HCoV-NL63) Inhibitors;3C Protease (Enterovirus 71) Inhibitors;3C-Like Protease (EMC Coronavirus) (HCoV-EMC) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Coronavirus IC-50 6.06E-06 M
SR9EK3 Nephrotoxicity induction, IN VITRO Nephrotoxicity Dye assay Vero African green monkey kidney cells CC-50 6.15E-06 M
Pristimerine Melanoma, metastatic remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Melanoma, metastatic Dye assay (alamar blue) B16F10 mouse metastatic melanoma cells CC-50 6.30E-06 M
Betulinic acid Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, colon (adenocarcinoma) Dye assay (sulforhodamine B) SW480 human colon adenocarcinoma cells CC-50 6.40E-06 M
Betulinic acid Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, colon (adenocarcinoma) Dye assay (sulforhodamine B) SW480 human colon adenocarcinoma cells CC-50 6.40E-06 M
Betulinic acid Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, colon (adenocarcinoma) Dye assay (sulforhodamine B) SW480 human colon adenocarcinoma cells CC-50 6.40E-06 M
Betulinic acid Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, colon (adenocarcinoma) Dye assay (sulforhodamine B) SW480 human colon adenocarcinoma cells CC-50 6.48E-06 M
Betulinic acid Cancer, colon (adenocarcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, colon (adenocarcinoma) Dye assay (sulforhodamine B) SW480 human colon adenocarcinoma cells CC-50 6.48E-06 M
Chloroquine Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Severe acute respiratory syndrome (SARS-CoV) Vero African green monkey kidney cells IC-50 6.50E-06 M
Betulinic acid Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, lung (non-small cell) (NSCLC) Dye assay A549 human non-small-cell lung carcinoma cells CC-50 6.65E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 6.70E-06 M
Psoralidin Estrogen Receptor beta (ERbeta) agonism, IN VITRO Estrogen Receptor (ER) beta Agonists;Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors;Estrogen Receptor (ER) alpha Agonists;5-Lipoxygenase Inhibitors;Signal Transduction Modulators;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;NF-kappaB (NFKB) Activation Inhibitors;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Caspase Activators;Apoptosis Inducers Estrogen Receptor beta (ERbeta) Luciferine/luciferase assay CV1 African green monkey kidney fibroblasts transfected with ERbeta receptor EC-50 6.88E-06 M
Quercetin Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Catechol-O-Methyl Transferase (COMT) Inhibitors;Drugs Targeting on Quorum Sensing Signaling;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;MAO-A Inhibitors;NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Activators;Signal Transduction Modulators;Lysosomal alpha-Glucosidase (GAA) Inhibitors;Xanthine Oxidase Inhibitors;EGFR (HER1; erbB1) Inhibitors;Cytokine Production Inhibitors;Antioxidants;Steryl-Sulfatase (STS) Inhibitors;Aldose Reductase Inhibitors;Sodium Channel Protein Type 5 Subunit alpha (Nav1.5) Channel Blockers;Free Radical Scavengers;Epigenetic Modifier Modulators;Wnt Signaling Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Uncompetitive inhibition mode Coronavirus (SARS-associated) Ki 7.00E-06 M
Betulinic acid Melanoma remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Melanoma Dye assay (MTS) SKMEL2 human melanoma cells CC-50 7.00E-06 M
Pristimerine Cancer, stomach remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, stomach N87 human gastric carcinoma cells CC-50 7.00E-06 M
Mucroporin-M1 Severe acute respiratory syndrome (SARS-CoV) remission/reduction, IN VITRO Cell Membrane Disrupting Agents Severe acute respiratory syndrome (SARS-CoV) Plaque assay HeLa human cervix adenocarcinoma cells IC-50 7.12E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 7.26E-06 M
Betulinic acid Cancer, thyroid, anaplastic remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, thyroid, anaplastic Dye assay (sulforhodamine B) 8505C human anaplastic thyroid carcinoma cells CC-50 7.26E-06 M
Isobavachalcone Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Replicase Polyprotein 1ab (pp1ab) (SARS) Arg-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin as substrate Coronavirus (SARS-associated) IC-50 7.30E-06 M
Papyriflavonol A Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Signal Transduction Modulators;Phospholipase A2 (PLA2) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Fluorescent assay Coronavirus (SARS-associated) IC-50 7.60E-06 M
Betulinic acid Cancer, lung (non-small cell) (NSCLC) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, lung (non-small cell) (NSCLC) Dye assay (sulforhodamine B) A549 human non-small-cell lung carcinoma cells CC-50 7.60E-06 M
Betulinic acid Cancer, breast (in situ ductal carcinoma) remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Cancer, breast (in situ ductal carcinoma) Clonogenic assay T47D human breast ductal carcinoma cells CC-50 7.66E-06 M
Pristimerine Hepatoblastoma remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Hepatoblastoma Dye assay (alamar blue) HepG2 human hepatoblastoma cells CC-50 7.80E-06 M
Pristimerine Cancer, breast (adenocarcinoma) remission/reduction, IN VITRO 3C-Like Protease (SARS-CoV) Inhibitors;Apoptosis Inducers;Microtubule Destabilizers (Tubulin Polymerization Inhibitors);Antimitotic Drugs Cancer, breast (adenocarcinoma) Dye assay (alamar blue) MCF7 human breast adenocarcinoma cells (hormone-dependent) CC-50 7.90E-06 M
Isobavachalcone Cancer, ovary remission/reduction, IN VITRO Inducible Nitric Oxide Synthase (NOS-2) Inhibitors;Steroid 5alpha-Reductase Inhibitors;Drugs Targeting Beta-Amyloid;Signal Transduction Modulators;Autophagy Inducers;Papain-Like Protease (PLpro) (SARS-CoV) Inhibitors;Antioxidants Cancer, ovary Dye assay (MTT) OVCAR8 human ovary carcinoma cells CC-50 7.92E-06 M
Broussochalcone A Replicase Polyprotein 1ab (pp1ab) (SARS) inhibition, IN VITRO Signal Transduction Modulators;Protein Kinase C (PKC) Inhibitors Replicase Polyprotein 1ab (pp1ab) (SARS) Uncompetitive inhibition mode Coronavirus (SARS-associated) Ki 8.00E-06 M
Quercetin NTPase inhibition, IN VITRO Catechol-O-Methyl Transferase (COMT) Inhibitors;Drugs Targeting on Quorum Sensing Signaling;Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1; PTP-1B) Inhibitors;MAO-A Inhibitors;NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Activators;Signal Transduction Modulators;Lysosomal alpha-Glucosidase (GAA) Inhibitors;Xanthine Oxidase Inhibitors;EGFR (HER1; erbB1) Inhibitors;Cytokine Production Inhibitors;Antioxidants;Steryl-Sulfatase (STS) Inhibitors;Aldose Reductase Inhibitors;Sodium Channel Protein Type 5 Subunit alpha (Nav1.5) Channel Blockers;Free Radical Scavengers;Epigenetic Modifier Modulators;Wnt Signaling Inhibitors NTPase Fluorescent assay Coronavirus (SARS-associated) IC-50 8.10E-06 M
Betulinic acid Melanoma remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Melanoma Dye assay (sulforhodamine B) 518A2 human melanoma cells CC-50 8.13E-06 M
Betulinic acid Melanoma remission/reduction, IN VITRO Signal Transduction Modulators;3C-Like Protease (SARS-CoV) Inhibitors;Caspase 3 Activators;Caspase 8 Activators;NF-kappaB (NFKB) Activators;Apoptosis Inducers;DNA Topoisomerase I Inhibitors;Diacylglycerol Acyltransferase (DGAT) Inhibitors Melanoma Dye assay (sulforhodamine B) 518A2 human melanoma cells CC-50 8.13E-06 M
Betulonic acid 3C-Like Protease (viral) inhibition, IN VITRO E3 Ubiquitin-Protein Ligase SIAH2 Inhibitors;Lysosomal alpha-Glucosidase (GAA) Inhibitors 3C-Like Protease (viral) Spectrophotometric assay Coronavirus (SARS-associated) Ki 8.20E-06 M
Eckol 3C-Like Protease (viral) inhibition, IN VITRO Lipid Peroxidation Inhibitors;Tyrosinase Inhibitors;Free Radical Scavengers 3C-Like Protease (viral) Fluorescence resonance energy transfer (FRET) assay Coronavirus (SARS-associated) Ki 8.20E-06 M

Unannotated preclinical studies

Literature Mining

  • A comprehensive literature mining result kindly provided by Causaly, focusing on chemicals/drugs, genes and molecular mechanisms. This data includes 2090 relationships, 1229 aggregrate relationships, and 976 articles based on a search query of "Chemicals&Drugs,Genes,Cellular&Molecular Mechanisms [AFFECTING] [Genus:Coronavirus]" with the data source coming from MEDLINE and PubMedCentral. This search resulted in several Target Concepts including: sars coronavirus, middle east respiratory syndrome coronavirus, human coronavirus, etc.
  • Full dataset

The following figure is the keyword relationship network:

Image of network

Full Image

  • The aggregate relationship data can be found in this dataset

  • This data describes source concept items and classifies them into different categories. Some relevant categories include: Amino Acid Peptide Protein, Biologically Active Substance, Chemical, Nucleic Acid, etc.

  • Literature articles and relationships data gives a list of 977 relevant articles and shows the evidence of the relationship from the original article.

  • Dataset

  • Literature evidence data lists all relevant source concepts (biological substances, chemicals, etc) and its relation to an article. Overall, there are over 2000 relevant pieces of information relevant to coronavirus.

  • Dataset

A few selected records

Source Concept Source Concept Categories Relationship Type Target Concept Count of Evidence Evidence contains clinical studies? Count of Evidence per rel type
cyclosporine "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 11 no DOWNREGULATE: 11
"rna, small interfering" Biologically Active Substance DOWNREGULATE sars coronavirus 9 no DOWNREGULATE: 9
linoleic acid Biologically Active Substance DOWNREGULATE middle east respiratory syndrome coronavirus 3 no "DOWNREGULATE: 2, UPREGULATE: 1"
resveratrol Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 7 no "DOWNREGULATE: 6, UPREGULATE: 1"
chloroquine Organic Chemical DOWNREGULATE sars coronavirus 14 no "DOWNREGULATE: 12, UPREGULATE: 2"
human leukocyte interferon "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 17 no "DOWNREGULATE: 11, UNIDIRECTIONAL: 4, UPREGULATE: 1, NEG_UNIDIRECTIONAL: 1"
gs-5734 "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE genus: coronavirus 4 no DOWNREGULATE: 4
zinc Biologically Active Substance DOWNREGULATE sars coronavirus 4 no DOWNREGULATE: 4
linoleic acid Biologically Active Substance DOWNREGULATE human coronavirus 229e 2 no "UPREGULATE: 1, DOWNREGULATE: 1"
fk-506 Organic Chemical DOWNREGULATE human coronavirus nl63 2 no DOWNREGULATE: 2
human leukocyte interferon "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 8 no "DOWNREGULATE: 5, UNIDIRECTIONAL: 2, UPREGULATE: 1"
lopinavir Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 4 no DOWNREGULATE: 4
ribavirin "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE middle east respiratory syndrome coronavirus 6 no "DOWNREGULATE: 5, UNIDIRECTIONAL: 1"
cyclosporine "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 3 no DOWNREGULATE: 3
gs-5734 "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE sars coronavirus 3 no DOWNREGULATE: 3
recombinant interferon alfa "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 5 no "DOWNREGULATE: 4, UNIDIRECTIONAL: 1"
"5-(n,n-hexamethylene)amiloride" Organic Chemical DOWNREGULATE human coronavirus 229e 4 no DOWNREGULATE: 4
chlorpromazine Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 3 no DOWNREGULATE: 3
chloroquine Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 3 no DOWNREGULATE: 3
interferon type i "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 5 no "DOWNREGULATE: 3, UNIDIRECTIONAL: 1, UPREGULATE: 1"
monoclonal antibodies "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 6 no "DOWNREGULATE: 3, UNIDIRECTIONAL: 2, UPREGULATE: 1"
glycyrrhizic acid Organic Chemical DOWNREGULATE sars coronavirus 3 no DOWNREGULATE: 3
protease inhibitors Pharmacologic Substance DOWNREGULATE sars coronavirus 3 no DOWNREGULATE: 3
kinase inhibitor [epc] Pharmacologic Substance DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
chloroquine Organic Chemical DOWNREGULATE genus: coronavirus 3 no "DOWNREGULATE: 2, UNIDIRECTIONAL: 1"
emodin Biologically Active Substance DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
emodin Biologically Active Substance DOWNREGULATE "coronavirus oc43, human" 2 no DOWNREGULATE: 2
beta-thujaplicin Organic Chemical DOWNREGULATE genus: coronavirus 2 no DOWNREGULATE: 2
ubiquitin "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 3 no DOWNREGULATE: 3
nucleoside analogs "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE genus: coronavirus 3 no "DOWNREGULATE: 2, UNIDIRECTIONAL: 1"
proteasome inhibitor Pharmacologic Substance DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
mycophenolic acid Antibiotic DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
loperamide Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
cyclophilins "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 2 no "DOWNREGULATE: 1, UPREGULATE: 1"
cytokine "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 3 no "DOWNREGULATE: 2, UNIDIRECTIONAL: 1"
lopinavir Organic Chemical DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
cyclosporine "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
alisporivir "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 2 no DOWNREGULATE: 2
glycosyltransferase "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
methyltransferase "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
u 18666a Organic Chemical DOWNREGULATE "coronavirus, feline" 2 no DOWNREGULATE: 2
"5-(n,n-hexamethylene)amiloride" Organic Chemical DOWNREGULATE genus: coronavirus 2 no DOWNREGULATE: 2
niclosamide Organic Chemical DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
"dpp4 protein, human" "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 5 no "DOWNREGULATE: 3, UPREGULATE: 1, UNIDIRECTIONAL: 1"
glycoproteins "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 2 no "DOWNREGULATE: 1, UPREGULATE: 1"
fumaric acid Organic Chemical DOWNREGULATE genus: coronavirus 2 no DOWNREGULATE: 2
protease inhibitors Pharmacologic Substance DOWNREGULATE genus: coronavirus 2 no DOWNREGULATE: 2
adenoviral vector "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
tapi-2 Organic Chemical DOWNREGULATE sars coronavirus 2 no DOWNREGULATE: 2
monoclonal antibodies "Amino Acid, Peptide, or Protein" DOWNREGULATE porcine respiratory coronavirus 2 no DOWNREGULATE: 2
s antibody "Amino Acid, Peptide, or Protein" DOWNREGULATE bovine coronavirus 2 no DOWNREGULATE: 2
interferon-alpha2b "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 3 no "DOWNREGULATE: 2, UNIDIRECTIONAL: 1"
human immunodeficiency virus 1 fusion inhibitor [epc] Pharmacologic Substance DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
ribavirin "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE sars coronavirus 12 no "DOWNREGULATE: 5, NEG_DOWNREGULATE: 4, UNIDIRECTIONAL: 2, UPREGULATE: 1"
platelets product Pharmacologic Substance DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
tylophorine Organic Chemical DOWNREGULATE genus: coronavirus 2 no "UPREGULATE: 1, DOWNREGULATE: 1"
riboflavin Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
recombinant interferon beta "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
"antibodies, neutralizing" "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 5 no "DOWNREGULATE: 2, UPREGULATE: 1, NEG_UPREGULATE: 1, NEG_DOWNREGULATE: 1"
ribavirin "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE genus: coronavirus 2 no DOWNREGULATE: 2
immune sera "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 2 no DOWNREGULATE: 2
nim-811 "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus nl63 1 no DOWNREGULATE: 1
alisporivir "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus nl63 1 no DOWNREGULATE: 1
fk-506 Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
fk-506 Organic Chemical DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
s-nitroso-n-acetylpenicillamine Biologically Active Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
hiv protease inhibitors Pharmacologic Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
nelfinavir Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
phospholipase c "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
disulfiram Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
disulfiram Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
scorpion venoms Biologically Active Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
interferon gamma [epc] "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
acetylglucosamine Organic Chemical DOWNREGULATE "coronavirus oc43, human" 1 no DOWNREGULATE: 1
gs-5734 "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE human coronavirus 1 no DOWNREGULATE: 1
terconazole Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
terconazole Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
phenanthrenes Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
pyrithione Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
chloroquine Organic Chemical DOWNREGULATE "coronavirus oc43, human" 1 no DOWNREGULATE: 1
saikosaponin b2 Organic Chemical DOWNREGULATE human coronavirus 1 no DOWNREGULATE: 1
isobavachalcone Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
herbacetin Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
helichrysetin Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
isoquercitrin Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
fc receptor "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
alisporivir "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
decanoylrvkrchloromethylketone "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
gs-5734 "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
nucleoside analogs "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
nucleoside analogs "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
nucleoside analogs "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE human coronavirus 1 no DOWNREGULATE: 1
cardiotonic agents Pharmacologic Substance DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
sodium Biologically Active Substance DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
aminoquinoline antimalarial (product) Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
interleukins "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
thiothixene Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
clomipramine Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
thioxanthenes Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
clomipramine Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
thiothixene Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
thioxanthenes Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
adenosine deaminase "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
chloroquine Organic Chemical DOWNREGULATE human coronavirus 1 no DOWNREGULATE: 1
tetra(4-n-methylpyridyl)porphine Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
alisporivir "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
teicoplanin "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
dalbavancin "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
telavancin "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
oritavancin "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
"antibodies, monoclonal, humanized" "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
ssya10-001 Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
protease inhibitors Pharmacologic Substance DOWNREGULATE "coronavirus, feline" 1 no DOWNREGULATE: 1
mercaptopurine "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
thioguanine Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
ssya10-001 Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
pj-34 Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
sb 203580 Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
interferon-alpha2b "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
synthetic peptide "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
chinese herbs Pharmacologic Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
nitric oxide Biologically Active Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
amiloride Organic Chemical DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
amiodarone Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
cystatins "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
glycine "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
anthelmintics Pharmacologic Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
anthelmintics Pharmacologic Substance DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
interferon beta-1a "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
polypeptide c "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
hexachlorophene Organic Chemical DOWNREGULATE bovine coronavirus 1 no DOWNREGULATE: 1
hexachlorophene Organic Chemical DOWNREGULATE human enteric coronavirus 1 no DOWNREGULATE: 1
hexachlorophene Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
palmitic acid Biologically Active Substance DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
mouse monoclonal antibody "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
gemcitabine "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
sotrastaurin Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
protein kinase c inhibitor Pharmacologic Substance DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
toremifene citrate Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
bcx4430 Biologically Active Substance DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
"ifitm1 protein, human" "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
glucose Biologically Active Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
antiviral agents Pharmacologic Substance DOWNREGULATE human coronavirus 1 no DOWNREGULATE: 1
iota-carrageenan Biologically Active Substance DOWNREGULATE "coronavirus oc43, human" 1 no DOWNREGULATE: 1
protease inhibitors Pharmacologic Substance DOWNREGULATE tylonycteris bat coronavirus hku4 1 no DOWNREGULATE: 1
omacetaxine Organic Chemical DOWNREGULATE bovine coronavirus 1 no DOWNREGULATE: 1
omacetaxine Organic Chemical DOWNREGULATE human enteric coronavirus 1 no DOWNREGULATE: 1
omacetaxine Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
dna helicases "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
cysteine proteases "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
e 64 Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
camostate-mesilate Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
camostate-mesilate Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
e 64 Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
kinase inhibitor [epc] Pharmacologic Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
protease inhibitors Pharmacologic Substance DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
bacillus intermedius ribonuclease "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
bacillus intermedius ribonuclease "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus 1 no DOWNREGULATE: 1
nafamostat Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
ritonavir Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
"m protein, multiple myeloma" "Amino Acid, Peptide, or Protein" DOWNREGULATE porcine respiratory coronavirus 1 no DOWNREGULATE: 1
u 18666a Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
human leukocyte interferon "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
glycyrrhizic acid Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
nitazoxanide Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
m nos antibody "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
antiviral agents Pharmacologic Substance DOWNREGULATE "coronavirus, feline" 1 no DOWNREGULATE: 1
camostat Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
baicalin Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
baicalein Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
zinc Biologically Active Substance DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
enzyme inhibitor drugs Pharmacologic Substance DOWNREGULATE human coronavirus hku1 1 no DOWNREGULATE: 1
paired basic amino acid cleaving enzyme "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus hku1 1 no DOWNREGULATE: 1
short hairpin rna "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
eosinophil cationic protein "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
mizoribine "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
aziridine Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
ritonavir Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
recombinant interferon beta-1a "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
veratridine Biologically Active Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
dactinomycin "Amino Acid, Peptide, or Protein" DOWNREGULATE "coronavirus, feline" 1 no DOWNREGULATE: 1
stallimycin "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
recombinant interferon alfa "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
cytokine "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
protein domain Amino Acid Sequence DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
immunoglobulin domains Amino Acid Sequence DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
heparitin sulfate Biologically Active Substance DOWNREGULATE betacoronavirus 1 no DOWNREGULATE: 1
itraconazole Organic Chemical DOWNREGULATE "coronavirus, feline" 1 no DOWNREGULATE: 1
recombinant interferon beta "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
cysteine proteases "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
papillomavirus transforming protein e6 "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 1 no DOWNREGULATE: 1
memantine Organic Chemical DOWNREGULATE "coronavirus oc43, human" 1 no DOWNREGULATE: 1
heparin Biologically Active Substance DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
ethanol Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
structural protein "Amino Acid, Peptide, or Protein" DOWNREGULATE "coronavirus, feline" 1 no DOWNREGULATE: 1
structural protein "Amino Acid, Peptide, or Protein" DOWNREGULATE "coronavirus, canine" 1 no DOWNREGULATE: 1
leupeptin "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
protein antibody "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
azauridine "Nucleic Acid, Nucleoside, or Nucleotide" DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
guanidine hydrochloride Organic Chemical DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
resveratrol Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus rna 1 no DOWNREGULATE: 1
"antibodies, anti-idiotypic" "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
phenothiazine Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
recombinant interleukin-4 "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
recombinant rantes "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
"tnf protein, human" "Amino Acid, Peptide, or Protein" DOWNREGULATE human coronavirus 229e 1 no DOWNREGULATE: 1
polyanion Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
ads j1 Organic Chemical DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
prostaglandin-endoperoxide synthase "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
plant extracts Biologically Active Substance DOWNREGULATE genus: coronavirus 1 no DOWNREGULATE: 1
hla complex "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 1 no DOWNREGULATE: 1
macrolides Organic Chemical DOWNREGULATE middle east respiratory syndrome coronavirus rna 2 no "NEG_UPREGULATE: 1, NEG_DOWNREGULATE: 1"
"antibodies, anti-idiotypic" "Amino Acid, Peptide, or Protein" DOWNREGULATE middle east respiratory syndrome coronavirus 4 no "DOWNREGULATE: 2, NEG_UPREGULATE: 2"
ssaa09e3 Organic Chemical DOWNREGULATE sars coronavirus 1 no NEG_DOWNREGULATE: 1
caspase "Amino Acid, Peptide, or Protein" DOWNREGULATE "coronavirus, canine" 1 no NEG_DOWNREGULATE: 1
phospholipase d "Amino Acid, Peptide, or Protein" DOWNREGULATE genus: coronavirus 1 no NEG_DOWNREGULATE: 1
proteolytic enzyme "Amino Acid, Peptide, or Protein" DOWNREGULATE sars coronavirus 2 no "UPREGULATE: 1, NEG_DOWNREGULATE: 1"
dipeptidyl-peptidase iv inhibitors Pharmacologic Substance DOWNREGULATE middle east respiratory syndrome coronavirus 3 no "NEG_DOWNREGULATE: 2, NEG_UNIDIRECTIONAL: 1"



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